Stefano Negri
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View article: The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells
The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells Open
The regeneration of the mammalian skeleton’s craniofacial bones necessitates the action of intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically and temporally to control the differentiation of o…
View article: Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma
Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma Open
Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation and often involves synovial lined tissues. During this process, mesenchymal progenitor cells undergo endochondral ossification. Nonetheless, the s…
View article: TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate Open
Pericytes are multipotent mesenchymal precursor cells that demonstrate tissue-specific properties. In this study, by comparing human adipose tissue- and periosteum-derived pericyte microarrays, we identified T cell lymphoma invasion and me…
View article: TrkA+ Neurons Induce Pathologic Regeneration After Soft Tissue Trauma
TrkA+ Neurons Induce Pathologic Regeneration After Soft Tissue Trauma Open
Heterotopic ossification (HO) is a dynamic, complex pathologic process that often occurs after severe polytrauma trauma, resulting in an abnormal mesenchymal stem cell differentiation leading to ectopic bone growth in soft-tissues includin…
View article: Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip
Acetabular Reaming Is a Reliable Model to Produce and Characterize Periarticular Heterotopic Ossification of the Hip Open
Heterotopic ossification (HO) is a pathologic process characterized by the formation of bone tissue in extraskeletal locations. The hip is a common location of HO, especially as a complication of arthroplasty. Here, we devise a first-of-it…
View article: NGF-p75 signaling coordinates skeletal cell migration during bone repair
NGF-p75 signaling coordinates skeletal cell migration during bone repair Open
Bone regeneration following injury is initiated by inflammatory signals and occurs in association with infiltration by sensory nerve fibers. Together, these events are believed to coordinate angiogenesis and tissue reprogramming, but the m…
View article: Could direct transdeltoid approach to severely displaced proximal humerus fracture be advantageous for a better reduction?
Could direct transdeltoid approach to severely displaced proximal humerus fracture be advantageous for a better reduction? Open
The results of this radiological study suggest that PHF with significant displacement of the grater tuberosity could benefit from the adoption of a lateral transdeltoid approach for the ORIF procedure. Further studies are needed to confirm…
View article: Impalement injuries of the shoulder: a case report with literature review.
Impalement injuries of the shoulder: a case report with literature review. Open
The management of penetrating skeletal extremity trauma is a clinical challenge even for experienced surgeons. While the treatment of associated vascular injuries should be prioritized, there is still a lack of evidence regarding the manag…
View article: PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair
PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair Open
The outer coverings of the skeleton, which is also known as the periosteum, are arranged in concentric layers and act as a reservoir for tissue-specific bone progenitors. The cellular heterogeneity within this tissue depot is being increas…
View article: The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal Nerves
The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal Nerves Open
The spatial distribution, innervation, and functional role of the bone-associated skeletal nerves have been previously reported in detail. However, studies examining exercise-induced associations between skeletal nerves and bone metabolism…
View article: Fine Needle Aspiration: who must perform this Procedure?
Fine Needle Aspiration: who must perform this Procedure? Open
In this historical moment, when FNA seems to have lost its paramount importance, it’s necessary to publish the data of the case study carried out from 2007 to 2014 in the pathologic anatomy unit at Carlo Poma Hospital in Mantua. This work …
View article: Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGF-β signaling
Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGF-β signaling Open
Significance Sensory nerves innervate bone and are required for normal skeletal development, but the molecular mechanisms through which nerves exert these essential functions have remained obscure. Here, we validate a spatial transcriptomi…
View article: Bone-Forming Perivascular Cells: Cellular Heterogeneity and Use for Tissue Repair
Bone-Forming Perivascular Cells: Cellular Heterogeneity and Use for Tissue Repair Open
Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tuni…
View article: NGF-p75 signaling coordinates skeletal cell migration during bone repair
NGF-p75 signaling coordinates skeletal cell migration during bone repair Open
Bone regeneration following injury is initiated by inflammatory signals and occurs in association with infiltration by sensory nerve fibers. Together, these events are believed to coordinate angiogenesis and tissue reprogramming, but the m…
View article: Divergent effects of distinct perivascular cell subsets for intra‐articular cell therapy in posttraumatic osteoarthritis
Divergent effects of distinct perivascular cell subsets for intra‐articular cell therapy in posttraumatic osteoarthritis Open
Intra‐articular injection of mesenchymal stem cells has shown benefit for the treatment of osteoarthritis (OA). However, mesenchymal stem/stromal cells at the origin of these clinical results are heterogenous cell populations with limited …
View article: Systemic DKK1 neutralization enhances human adipose-derived stem cell mediated bone repair
Systemic DKK1 neutralization enhances human adipose-derived stem cell mediated bone repair Open
Progenitor cells from adipose tissue are able to induce bone repair; however, inconsistent or unreliable efficacy has been reported across preclinical and clinical studies. Soluble inhibitory factors, such as the secreted Wnt signaling ant…
View article: The Complexity of the Anticholinergic Burden in Frail Older Persons
The Complexity of the Anticholinergic Burden in Frail Older Persons Open
The significant impact that some classes of drugs may have on older and frail people is nowadays an emerging issue. In particular, anticholinergics play a central role in this field. The systematic review and meta-analysis conducted by St…
View article: Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells
Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells Open
Tissue resident mesenchymal stem/stromal cells (MSCs) occupy perivascular spaces. Profiling human adipose perivascular mesenchyme with antibody arrays identified 16 novel surface antigens, including endolysosomal protein CD107a. Surface CD…
View article: Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation
Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation Open
The vascular wall stores mesenchymal progenitor cells which are able to induce bone regeneration, via direct and paracrine mechanisms. Although much is known regarding perivascular cell regulation of osteoblasts, their regulation of osteoc…
View article: Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification
Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification Open
Heterotopic ossification (HO) is defined as abnormal differentiation of local stromal cells of mesenchymal origin, resulting in pathologic cartilage and bone matrix deposition. Cyr61, CTGF, Nov (CCN) family members are matricellular protei…
View article: Central metatarsal fractures: a review and current concepts.
Central metatarsal fractures: a review and current concepts. Open
Central metatarsal fractures (CMF) are common injuries. More frequently fractures are those of the fifth metatarsal, followed by CMF and therefore by the first metatarsal. Third metatarsal is injured most frequently than the others and up …
View article: Anti-DKK1 Enhances the Early Osteogenic Differentiation of Human Adipose-Derived Stem/Stromal Cells
Anti-DKK1 Enhances the Early Osteogenic Differentiation of Human Adipose-Derived Stem/Stromal Cells Open
Adipose-derived stem/stromal cells (ASCs) have been previously used for bone repair. However, significant cell heterogeneity exists within the ASC population, which has the potential to result in unreliable bone tissue formation and/or low…