2024-07-09
Nanoscopic gel particle for intra-articular injection formulation
2024-07-09 • Xiaoyu Han, Stefano Scialla, Emanuele Limiti, Edward T. Davis, Marcella Trombetta, Alberto Rainer, Simon W. Jones, Emanuele Mauri, Zhenyu J. Zhang
Hyaluronic acid (HA) based nanogels showed effective intracellular delivery efficacy for anti-cancer and anti-inflammatory drugs, characterized by their ability targeting relevant cell receptors. In the present study, we demonstrate the ability of hyaluronic acid-polyethyleneimine (HA-PEI) nanogels as a promising dual-functional interfacial active for intra-articular injection to intervene arthritis. Nanomechanical measurements on both model substrates and human cartilage samples confirm that the HA-PEI nanogels c…