Stefano Stuard
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View article: Psychometric Validation of the KDQoL-36 in Dialysis Using Item Response Theory and Computer Adaptive Testing
Psychometric Validation of the KDQoL-36 in Dialysis Using Item Response Theory and Computer Adaptive Testing Open
Background Health-Related Quality of Life (HRQoL) is a critical outcome in end-stage kidney disease care. The Kidney Disease Quality of Life-36 (KDQoL-36) is widely used but presents limitations in length and personalization, which may red…
View article: Choosing the right antihypertensive drug to avoid intrahemodialysis hypotension
Choosing the right antihypertensive drug to avoid intrahemodialysis hypotension Open
Intradialytic hypotension (IDH) is a significant complication in hemodialysis (HD) patients, affecting cardiovascular stability and treatment outcomes. Antihypertensive medications, while crucial for blood pressure control, can exacerbate …
View article: #914 AI-powered identification of UFR-sensitive and insensitive patients to mitigate intradialytic hypotension
#914 AI-powered identification of UFR-sensitive and insensitive patients to mitigate intradialytic hypotension Open
Background and Aims Intradialytic hypotension (IDH) is a common complication of hemodialysis that negatively affects patients’ quality of life and increases mortality risk. One strategy to mitigate IDH involves lowering the ultrafiltration…
View article: #2360 Impact of fluid overload changes within the first 6 months of dialysis on hospitalization during a two-year follow-up
#2360 Impact of fluid overload changes within the first 6 months of dialysis on hospitalization during a two-year follow-up Open
Background and Aims Fluid overload (FO) is a known risk factor for mortality in dialysis patients; however, less is known about its risk for hospitalization and factors associated with changes in FO. Whole-body bioimpedance spectroscopy (B…
View article: #2234 Age and kidney failure etiology: global profiles in Apollo <i>DialDb</i>
#2234 Age and kidney failure etiology: global profiles in Apollo <i>DialDb</i> Open
Background and Aims The cause of kidney failure is suggested to differ by age. Understanding age-specific differences in kidney failure etiology is crucial for optimizing care paradigms. This study aims to explore these variations globally…
View article: #2224 <b>Age-related cardiovascular disease burden in dialysis: insights from ApolloDialDb</b>
#2224 <b>Age-related cardiovascular disease burden in dialysis: insights from ApolloDialDb</b> Open
Background and Aims The association between chronic kidney disease (CKD) and cardiovascular disease (CVD) was first published by the British physician, Richard Bright, in the 19th century [1]. The American Heart Association published work …
View article: Creating a Globally Distributed Multinational Dialysis Database - The ApolloDialDb Initiative
Creating a Globally Distributed Multinational Dialysis Database - The ApolloDialDb Initiative Open
Creating a robust multinational dialysis database offers vast opportunities to conduct real-world research and data analytics, including the development of artificial intelligence models. These activities hold promise of advancing the unde…
View article: Increased risk of cardiac death with cumulative exposure to fluid overload and dialysate sodium ≤138 mmol/l in hemodialysis patients
Increased risk of cardiac death with cumulative exposure to fluid overload and dialysate sodium ≤138 mmol/l in hemodialysis patients Open
Background Fluid overload (FO) is an established risk factor for mortality in hemodialysis patients, who face higher cardiovascular mortality risk than the general population. Despite the known impact of FO on cardiovascular outcomes, the …
View article: Why High-Volume Post-Dilution Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms
Why High-Volume Post-Dilution Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms Open
The management of end-stage kidney disease (ESKD) poses a substantial clinical and economic challenge, characterized by a growing patient burden, rising healthcare costs, and persistent unmet needs to enhance survival outcomes and quality …
View article: Why High-Volume Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms
Why High-Volume Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms Open
The management of end-stage kidney disease (ESKD) poses a substantial clinical and economic challenge, characterized by a growing patient burden, rising healthcare costs, and persistent unmet needs to enhance survival outcomes and quality …
View article: High-Volume Hemodiafiltration: Expanding the Evidence Beyond Randomized Trials—A Critical Perspective on the 2025 EuDial Consensus
High-Volume Hemodiafiltration: Expanding the Evidence Beyond Randomized Trials—A Critical Perspective on the 2025 EuDial Consensus Open
The 2025 EuDial Consensus systematically compared hemodiafiltration (HDF) to high-flux hemodialysis (HD), highlighting HDF’s superior removal of middle-molecular-weight uremic toxins, potential survival advantages, and immunomodulatory pro…
View article: High-Volume Hemodiafiltration: Expanding the Evidence Beyond Randomized Trials – A Critical Perspective on the 2025 EuDial Consensus
High-Volume Hemodiafiltration: Expanding the Evidence Beyond Randomized Trials – A Critical Perspective on the 2025 EuDial Consensus Open
The 2025 EuDial Consensus systematically compared hemodiafiltration (HDF) to high-flux hemodialysis (HD), highlighting HDF's superior removal of middle-molecular-weight uremic toxins, potential survival advantages, and immunomodulator…
View article: WCN25-4092 SODIUM GRADIENT AND ALL-CAUSE MORTALITY IN INCIDENT MAINTENANCE HEMODIALYSIS PATIENTS: RESULTS FROM THE MONitoring Dialysis Outcomes (MONDO) INITIATIVE
WCN25-4092 SODIUM GRADIENT AND ALL-CAUSE MORTALITY IN INCIDENT MAINTENANCE HEMODIALYSIS PATIENTS: RESULTS FROM THE MONitoring Dialysis Outcomes (MONDO) INITIATIVE Open
View article: Real-world effectiveness of hemodialysis modalities: a retrospective cohort study
Real-world effectiveness of hemodialysis modalities: a retrospective cohort study Open
Our results suggest that hemodiafiltration has a beneficial effect on all-cause and cardiovascular mortality in a large, unselected patient population and across patient subgroups in real-world settings. Our study complements evidence from…
View article: CKD-Associated Pruritus is Associated with Greater Use of Antidepressants and Anti-pruritus Medications
CKD-Associated Pruritus is Associated with Greater Use of Antidepressants and Anti-pruritus Medications Open
Patterns of antipruritic medication use in a cohort of patients with CKD-aP was identified and the frequent use of off-label treatments in the absence of approved therapies was highlighted. These observations reflect clinical practices aim…
View article: Kidney Disease: Improving Global Outcomes (KDIGO) Workshop on the Nurse’s Role in Managing the Symptoms of People Receiving Dialysis
Kidney Disease: Improving Global Outcomes (KDIGO) Workshop on the Nurse’s Role in Managing the Symptoms of People Receiving Dialysis Open
Adults with kidney failure receiving dialysis frequently report high symptom burden that can limit life participation and decrease the quality of life. Fatigue, itch, pain, anxiety, depressive symptoms, sleep problems, nausea, vomiting, mu…
View article: Better health-related quality of life is associated with prolonged survival and reduced hospitalization risk among dialysis-dependent chronic kidney disease patients: a historical cohort study
Better health-related quality of life is associated with prolonged survival and reduced hospitalization risk among dialysis-dependent chronic kidney disease patients: a historical cohort study Open
Several dimensions of HRQoL are associated with patient-centered outcomes (i.e., mortality and hospitalizations at 1 year). Patient-Reported Outcomes contribute unique pieces of information characterizing patients' health. Residual confoun…
View article: The effects of dialysate calcium prescription on mortality outcomes in incident patients on hemodialysis
The effects of dialysate calcium prescription on mortality outcomes in incident patients on hemodialysis Open
Background The appropriate prescription of dialysate calcium concentration for hemodialysis is debated. We investigated the association between dialysate calcium and all-cause, cardiovascular mortality and sudden cardiac death. Methods In …
View article: Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis
Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis Open
Introduction: The management of anemia in chronic kidney disease (CKD-An) presents significant challenges for nephrologists due to variable responsiveness to erythropoietin-stimulating agents (ESAs), hemoglobin (Hb) cycling, and multiple c…
View article: Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis
Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis Open
Introduction. The management of anemia in chronic kidney disease (CKD-An) presents significant challenges for nephrologists due to variable responsiveness to erythropoietin-stimulating agents (ESA), hemoglobin (Hb) cycling, and multiple cl…
View article: Associations of Abnormal Fluid Status, Plasma Sodium Disorders, and Low Dialysate Sodium with Mortality in Patients on Hemodialysis
Associations of Abnormal Fluid Status, Plasma Sodium Disorders, and Low Dialysate Sodium with Mortality in Patients on Hemodialysis Open
Key Points This multicenter observational study followed 68,196 patients on hemodialysis over a decade and investigated the effect of cumulative exposure burden of abnormal fluid and sodium concentrations and dialysate sodium on mortality.…
View article: Hemodialysis Procedures for Stable Incident and Prevalent Patients Optimize Hemodynamic Stability, Dialysis Dose, Electrolytes, and Fluid Balance
Hemodialysis Procedures for Stable Incident and Prevalent Patients Optimize Hemodynamic Stability, Dialysis Dose, Electrolytes, and Fluid Balance Open
The demographic profile of patients transitioning from chronic kidney disease to kidney replacement therapy is changing, with a higher prevalence of aging patients with multiple comorbidities such as diabetes mellitus and heart failure. Ca…
View article: Does online high-volume hemodiafiltration offer greater efficiency and sustainability compared with high-flux hemodialysis? A detailed simulation analysis anchored in real-world data
Does online high-volume hemodiafiltration offer greater efficiency and sustainability compared with high-flux hemodialysis? A detailed simulation analysis anchored in real-world data Open
Recent findings, including the CONVINCE (comparison of high-dose HDF with high-flux HD) study report, suggest the superiority of high-volume hemodiafiltration (HDF) over high-flux hemodialysis (HD) in improving patients’ outcomes. Despite …
View article: #1157 Body mass and fluid balance in dialysis: global profiles in Apollo Dial DB
#1157 Body mass and fluid balance in dialysis: global profiles in Apollo Dial DB Open
Background and Aims Fluid management is a fundamental component of dialysis care. Achieving euvolemia and avoiding fluid overload can be challenging in dialysis. Apollo Dial DB, an anonymised dialysis database from a global kidney care net…
View article: #341 Dialysis modality patterns across six continents in Apollo Dial DB
#341 Dialysis modality patterns across six continents in Apollo Dial DB Open
Background and Aims Data is often collected during kidney dialysis treatments, providing data on a large scale and at a constant flow. As multinational datasets are scarce, Apollo Dial DB was created by a global provider that contains long…
View article: #1657 Impact of cumulative fluid and sodium imbalance exposure on cause-specific mortality in hemodialysis
#1657 Impact of cumulative fluid and sodium imbalance exposure on cause-specific mortality in hemodialysis Open
Background and Aims Even mild fluid overload and prolonged exposure to salt excess showed to be associated with all-cause mortality in hemodialysis patients. This analysis aims to estimate the effect of fluid and sodium imbalance on cause-…
View article: #2742 Artificial intelligence accurately approximates MGPE dose response relationship in a North American Dialysis Population
#2742 Artificial intelligence accurately approximates MGPE dose response relationship in a North American Dialysis Population Open
Background and Aims The Anemia Control Model (ACM) is a certified medical device aimed at optimizing the management of CKD-related anemia among patients on dialysis. ACM is based on an artificial neural network (ANN) trained on over 900’00…
View article: Better Health-Related Quality of Life is associated with prolonged survival and reduced hospitalization risk among Dialysis-Dependent Chronic Kidney Disease Patients: A Historical Cohort Study
Better Health-Related Quality of Life is associated with prolonged survival and reduced hospitalization risk among Dialysis-Dependent Chronic Kidney Disease Patients: A Historical Cohort Study Open
Rationale & Objective. End-stage kidney disease (ESKD) negatively affects patients’ physical, emotional, and social functioning. Furthermore, adjustment to dialysis require substantial lifestyle changes that may further impact on patients …
View article: Hemodialysis Procedures for Stable Incident and Prevalent Patients to Optimize Hemodynamic Stability, Dialysis Dose, Electrolytes, and Fluid Balance
Hemodialysis Procedures for Stable Incident and Prevalent Patients to Optimize Hemodynamic Stability, Dialysis Dose, Electrolytes, and Fluid Balance Open
The demographic profile of patients transitioning from chronic kidney disease to renal replacement therapy is changing, with a higher prevalence of aging patients with multiple comorbidities such as diabetes mellitus and heart failure. Car…
View article: WCN24-1206 GLOBAL DIALYSIS CHARACTERISTICS ACROSS SIX CONTINENTS IN THE APOLLO DB DATASET
WCN24-1206 GLOBAL DIALYSIS CHARACTERISTICS ACROSS SIX CONTINENTS IN THE APOLLO DB DATASET Open
A considerable amount of data is captured during the care of dialysis patients. This data can be used for secondary purposes to understand the delivery of care and advance treatment models. Despite this, multinational datasets are scarce d…