Stefano Tacconi
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View article: A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery
A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery Open
Our findings support the use of rennet combined with SEC or TFF to produce MEVs as scalable, safe, and effective delivery systems, offering a promising platform for future nutraceutical and pharmaceutical applications. In parallel, the stu…
View article: Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells
Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells Open
View article: M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment
M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment Open
Background Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, the consequences of …
View article: Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics
Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics Open
Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy to electricity. The bottleneck in these technologies is the limited electron transfer between the microbe and the…
View article: M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment
M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment Open
Background Macrophages release not only cytokines but also extracellular vesicles (EVs). EVs are small lipid-derived vesicles with virus-like properties transferring lipids, RNA and proteins between cells. Until now, the consequences of ma…
View article: Stable Microsponges by Spray Drying of Tempo-Oxidized Cellulose Nanofibers: Synthesis and Characterization for Controlled Drug Release
Stable Microsponges by Spray Drying of Tempo-Oxidized Cellulose Nanofibers: Synthesis and Characterization for Controlled Drug Release Open
View article: Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl4-Induced Liver Fibrosis in Rats
Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl4-Induced Liver Fibrosis in Rats Open
Hepatic fibrosis (HF) is a major cause of liver-related disorders and together with cancer-associated fibroblasts can favor liver cancer development by modulating the tumor microenvironment. Advanced HF, characterized by an excess of extra…
View article: A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential
A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential Open
Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic…
View article: An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model Open