Steffen Backert
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View article: Enhanced ADP-Heptose-dependent NF-κB activation by <i>Helicobacter pylori</i> CagA through cortactin-Src-dependent tyrosine phosphorylation of IKKβ
Enhanced ADP-Heptose-dependent NF-κB activation by <i>Helicobacter pylori</i> CagA through cortactin-Src-dependent tyrosine phosphorylation of IKKβ Open
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) represents a family of important transcription factors in innate immunity. We have previously reported that the gastric pathogen Helicobacter pylori needs the actin-bin…
View article: Extracts from Plectranthus asirensis and Premna resinosa inhibit Helicobacter pylori-induced epithelial cell damage, DNA double-strand breaks and inflammation
Extracts from Plectranthus asirensis and Premna resinosa inhibit Helicobacter pylori-induced epithelial cell damage, DNA double-strand breaks and inflammation Open
Background Helicobacter pylori infection is a major global health issue associated with chronic gastritis, peptic ulcers, and gastric cancer. Due to the increasing resistance of H. pylori to conventional antibiotics, there is growing inter…
View article: Molecular characterization of four <i>Helicobacter cetorum</i> strains from dolphins compared to human <i>Helicobacter pylori</i>
Molecular characterization of four <i>Helicobacter cetorum</i> strains from dolphins compared to human <i>Helicobacter pylori</i> Open
Helicobacter species colonize the stomachs of many aquatic and terrestrial mammals, including Helicobacter pylori in humans and Helicobacter cetorum in dolphins. There are several H. cetorum genome sequences in databases, but a detailed mo…
View article: Roles of the lipopolysaccharide biosynthesis-related gene <i>HP0858</i> in the fitness of <i>Helicobacter pylori</i> and its virulence in <i>Galleria mellonella</i>
Roles of the lipopolysaccharide biosynthesis-related gene <i>HP0858</i> in the fitness of <i>Helicobacter pylori</i> and its virulence in <i>Galleria mellonella</i> Open
Helicobacter pylori is a pathogenic bacterium associated with the development of gastric cancer and other gastric disorders. One of its major virulence factors, lipopolysaccharide (LPS), plays a crucial role in maintaining bacterial integr…
View article: Bacterial Extracellular Vesicles Exploit Filopodial Surfing and Retraction Mechanisms to Reach the Host Cell Body in an Actin‐Dependent Manner
Bacterial Extracellular Vesicles Exploit Filopodial Surfing and Retraction Mechanisms to Reach the Host Cell Body in an Actin‐Dependent Manner Open
Extracellular vesicles derived from gram‐negative bacteria are nano‐sized particles of different size and origin released by these microbes and are collectively called bacterial extracellular vesicles (BEVs). These BEVs may serve as vehicl…
View article: Therapeutic and protective approaches to combat Campylobacter jejuni infections
Therapeutic and protective approaches to combat Campylobacter jejuni infections Open
Campylobacter jejuni is a typical zoonotic bacterium, colonizing the gut of many bird species as commensal. In humans, C. jejuni is a major foodborne pathogen. Infection of humans causes campylobacteriosis in the small intestine, constitut…
View article: The Influence of Gastric Microbiota and Probiotics in Helicobacter pylori Infection and Associated Diseases
The Influence of Gastric Microbiota and Probiotics in Helicobacter pylori Infection and Associated Diseases Open
The role of microbiota in human health and disease is becoming increasingly clear as a result of modern microbiome studies in recent decades. The gastrointestinal tract is the major habitat for microbiota in the human body. This microbiota…
View article: Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children
Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children Open
Background Helicobacter pylori is a persistent pathogen in the human stomach. However, the proposed transmission route via the oral cavity is not understood and under intense debate. While dozens of studies have shown by PCR that H. pylori…
View article: Cortactin: A major cellular target of viral, protozoal, and fungal pathogens
Cortactin: A major cellular target of viral, protozoal, and fungal pathogens Open
Many viral, protozoal, and fungal pathogens represent major human and animal health problems due to their great potential of causing infectious diseases. Research on these pathogens has contributed substantially to our current understandin…
View article: Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori
Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori Open
Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen Helicobacter pylori. Those …
View article: Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection Open
Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncop…
View article: Campylobacter jejuni Surface-Bound Protease HtrA, but Not the Secreted Protease nor Protease in Shed Membrane Vesicles, Disrupts Epithelial Cell-to-Cell Junctions
Campylobacter jejuni Surface-Bound Protease HtrA, but Not the Secreted Protease nor Protease in Shed Membrane Vesicles, Disrupts Epithelial Cell-to-Cell Junctions Open
Fundamental functions of the intestinal epithelium include the digestion of food, absorption of nutrients, and its ability to act as the first barrier against intruding microbes. Campylobacter jejuni is a major zoonotic pathogen accounting…
View article: Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer
Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer Open
Fusobacterium nucleatum is supposed to play a critical role in the development of colorectal cancer. The species has also been associated with ulcerative colitis (UC) that can progress into colorectal cancer, however, the involvement of ba…
View article: Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain
Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain Open
The human pathogen Helicobacter pylori is a major risk factor for gastric disease development. Serine protease HtrA is an important bacterial virulence factor that cleaves the cell junction proteins occludin, claudin-8 and E-cadherin, whic…
View article: Molecular Targets in Campylobacter Infections
Molecular Targets in Campylobacter Infections Open
Human campylobacteriosis results from foodborne infections with Campylobacter bacteria such as Campylobacter jejuni and Campylobacter coli, and represents a leading cause of bacterial gastroenteritis worldwide. After consumption of contami…
View article: Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis
Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis Open
Infection with the main human food-borne pathogen Campylobacter jejuni causes campylobacteriosis that accounts for a substantial percentage of gastrointestinal infections. The disease usually manifests as diarrhea that lasts for up to two …
View article: Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens
Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens Open
Pathogenic bacteria possess a great potential of causing infectious diseases and represent a serious threat to human and animal health. Understanding the molecular basis of infection development can provide new valuable strategies for dise…
View article: Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacter pylori
Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacter pylori Open
Infection of the stomach by Helicobacter pylori is a major risk factor for the development of gastric cancer. Colonization of the gastric epithelium leads to the activation of multiple disease-related signaling pathways. Serine protease Ht…
View article: Campylobacter jejuni Serine Protease HtrA Induces Paracellular Transmigration of Microbiota across Polarized Intestinal Epithelial Cells
Campylobacter jejuni Serine Protease HtrA Induces Paracellular Transmigration of Microbiota across Polarized Intestinal Epithelial Cells Open
Campylobacter jejuni represents an eminent zoonotic germ responsible for foodborne infections causing campylobacteriosis. In addition, infections with C. jejuni constitute a risk factor for the occurrence of inflammatory bowel disease (IBD…
View article: Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins
Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins Open
The genomes of the gastric bacterial pathogen Helicobacter pylori harbor multiple type-IV secretion systems (T4SSs). Here we analyzed components of three T4SSs, the cytotoxin-associated genes ( cag ) T4SS, TFS3 and TFS4. The cag T4SS deliv…
View article: Importance of cortactin for efficient epithelial NF-ĸB activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp.
Importance of cortactin for efficient epithelial NF-ĸB activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp. Open
Transcription factors of the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF-ĸB) family control important signaling pathways in the regulation of the host innate immune system. Various bacterial pathogens in the human ga…
View article: Rapid Detection of Quinolone Resistance Mutations in gyrA of Helicobacter pylori by Real-Time PCR
Rapid Detection of Quinolone Resistance Mutations in gyrA of Helicobacter pylori by Real-Time PCR Open
The treatment of infections by the gastric pathogen Helicobacter pylori (H. pylori) has become more difficult due to increased rates of resistances against various antibiotics. Typically, atriple therapy, employing a combination of at leas…
View article: Cortactin Promotes Effective AGS Cell Scattering by Helicobacter pylori CagA, but Not Cellular Vacuolization and Apoptosis Induced by the Vacuolating Cytotoxin VacA
Cortactin Promotes Effective AGS Cell Scattering by Helicobacter pylori CagA, but Not Cellular Vacuolization and Apoptosis Induced by the Vacuolating Cytotoxin VacA Open
Cortactin is an actin-binding protein and actin-nucleation promoting factor regulating cytoskeletal rearrangements in eukaryotes. Helicobacter pylori is a gastric pathogen that exploits cortactin to its own benefit. During infection of gas…
View article: Helicobacter pylori and the gut microbiota
Helicobacter pylori and the gut microbiota Open
The gut microbiota inherits fundamental functions in the preservation of human health properties as they are crucial for nutrient acquisition and digestive properties, energy metabolism, and training of host immunity functions. Colonizatio…
View article: Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation
Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation Open
The pathogen Helicobacter pylori is the first reported bacterial type-1 carcinogen playing a role in the development of human malignancies, including gastric adenocarcinoma. Cancer cell motility is an important process in this scenario, ho…
View article: Vitamin D Reverses Disruption of Gut Epithelial Barrier Function Caused by Campylobacter jejuni
Vitamin D Reverses Disruption of Gut Epithelial Barrier Function Caused by Campylobacter jejuni Open
Infections by the zoonotic foodborne bacterium Campylobacter jejuni (C. jejuni) are among the most frequent causes of bacterial gastroenteritis worldwide. The aim was to evaluate the relationship between epithelial barrier disruption, muco…