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View article: Polymorphisms in the <scp>NF</scp>kB, <scp>TNF</scp>‐alpha, <scp>IL</scp>‐1beta, and <scp>IL</scp>‐18 pathways are associated with response to anti‐<scp>TNF</scp> therapy in Danish patients with inflammatory bowel disease
Polymorphisms in the <span>NF</span>kB, <span>TNF</span>‐alpha, <span>IL</span>‐1beta, and <span>IL</span>‐18 pathways are associated with response to anti‐<span>TNF</span> therapy in Danish patients with inflammatory bowel disease Open
Summary Background Anti‐tumor necrosis factor‐α ( TNF ‐α) is used for the treatment of severe cases of IBD , including Crohn's disease ( CD ) and ulcerative colitis ( UC ). However, one‐third of the patients do not respond to the treatment…
View article: Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis
Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis Open
Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or p…
View article: Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis
Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects ~1% of the Caucasian population. Over the last decades, the availability of biological drugs targeting the proinflammatory cytokine tumour necrosis factor α, anti-TNF…
View article: Systematic review: genetic biomarkers associated with anti‐TNF treatment response in inflammatory bowel diseases
Systematic review: genetic biomarkers associated with anti‐TNF treatment response in inflammatory bowel diseases Open
Summary Background Personalised medicine, including biomarkers for treatment selection, may provide new algorithms for more effective treatment of patients. Genetic variation may impact drug response and genetic markers could help selectin…