Steffen Gretser
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View article: Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients
Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients Open
View article: Maschinelles Lernen zur Identifikation pathologischer Myokardregionen: ein innovativer Ansatz für die digitale Pathologie
Maschinelles Lernen zur Identifikation pathologischer Myokardregionen: ein innovativer Ansatz für die digitale Pathologie Open
Zusammenfassung Hintergrund/Fragestellung Digitalisierung und künstliche Intelligenz (KI) werden zunehmend in der Auswertung histologischer Schnitte getestet und eingesetzt. Während die Anwendung im Bereich der Tumorpathologie bereits weit…
View article: Expression of claudin‐18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre
Expression of claudin‐18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre Open
Aims Anti‐claudin‐18.2 (CLDN18.2) therapy was recently approved for the treatment of gastric or gastro‐oesophageal junction adenocarcinoma. The aim of the present study was to investigate the expression of CLDN18.2 in cholangiocarcinoma (C…
View article: Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention
Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention Open
Background: Necrotizing enterocolitis (NEC) is a common disease in premature infants. If conservative treatment does not respond, surgical removal of the necrotic section of bowel is common practice. This study investigates whether there i…
View article: Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors
Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors Open
View article: Fluorescence Confocal Microscopy Can Accelerate Diagnosis of Cervical Lymphadenopathy
Fluorescence Confocal Microscopy Can Accelerate Diagnosis of Cervical Lymphadenopathy Open
View article: Checkpoint inhibition enhances cell contacts between CD4<sup>+</sup> T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma
Checkpoint inhibition enhances cell contacts between CD4<sup>+</sup> T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma Open
Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies …
View article: Fluoreszenzbasierte Konfokalmikroskopie – vollständige Digitalisierung der Pathologie
Fluoreszenzbasierte Konfokalmikroskopie – vollständige Digitalisierung der Pathologie Open
View article: Heterogeneity of small duct‐ and large duct‐type intrahepatic cholangiocarcinoma
Heterogeneity of small duct‐ and large duct‐type intrahepatic cholangiocarcinoma Open
Aims The histological subtype of intrahepatic cholangiocarcinoma (iCCA) is associated with different mutational characteristics that impact clinical management. So far, data are lacking on the presence of small duct iCCA (SD‐iCCA) and larg…
View article: Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien
Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien Open
View article: Die Modelltransferierbarkeit von KI in der digitalen Pathologie
Die Modelltransferierbarkeit von KI in der digitalen Pathologie Open
Zusammenfassung Ziel der Arbeit Künstliche Intelligenz hat das Potenzial, in der Pathologie weitreichende Fortschritte zu erzielen. Doch die tatsächliche Anwendung und Zertifizierung für die Praxis bleibt begrenzt, oft aufgrund von Herausf…
View article: Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma
Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma Open
View article: Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma
Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma Open
Data on the impact of autophagy in primary cholangiocarcinoma (CCA) remain scarce. Here, we therefore investigated the role of active autophagy and its impact on survival in CCA patients. All CCA patients who underwent surgical resection w…
View article: Tissue Shrinkage of Resected Specimens in Hirschsprung’s Disease: Why Pediatric Surgeons Think the Bowel Specimen was Longer Than Indicated in the Pathology Report
Tissue Shrinkage of Resected Specimens in Hirschsprung’s Disease: Why Pediatric Surgeons Think the Bowel Specimen was Longer Than Indicated in the Pathology Report Open
Background: Hirschsprung disease (HD) is an aganglionosis of variable length starting at the rectosigmoid colon with surgery as sole therapeutic option. The length of the resected bowel segment is a crucial information for the treating sur…
View article: Expression of MUC16/CA125 Is Associated with Impaired Survival in Patients with Surgically Resected Cholangiocarcinoma
Expression of MUC16/CA125 Is Associated with Impaired Survival in Patients with Surgically Resected Cholangiocarcinoma Open
MUC16/CA125 is associated with cancer proliferation in several tumor entities. The data on MUC16 expression in cholangiocarcinoma (CCA) tissue are very limited. The aim of this study was to assess the MUC16 status and its impact on surviva…
View article: How to learn with intentional mistakes: NoisyEnsembles to overcome poor tissue quality for deep learning in computational pathology
How to learn with intentional mistakes: NoisyEnsembles to overcome poor tissue quality for deep learning in computational pathology Open
There is a lot of recent interest in the field of computational pathology, as many algorithms are introduced to detect, for example, cancer lesions or molecular features. However, there is a large gap between artificial intelligence (AI) t…
View article: Abstracts des 74. Kongresses der Deutschen Gesellschaft für Urologie e. V.
Abstracts des 74. Kongresses der Deutschen Gesellschaft für Urologie e. V. Open
View article: Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma Open
In gastric cancer (GC), there are four molecular subclasses that indicate whether patients respond to chemotherapy or immunotherapy, according to the TCGA. In clinical practice, however, not every patient undergoes molecular testing. Many …
View article: Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy
Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy Open
View article: Leydig Cell Tumor in a Patient with 46,XX Disorder of Sex Development (DSD), Ovotesticular: A Case Report and a Review of the Literature
Leydig Cell Tumor in a Patient with 46,XX Disorder of Sex Development (DSD), Ovotesticular: A Case Report and a Review of the Literature Open
Disorder of sex development (DSD) is a rare condition with atypical development of chromosomal, gonadal, or anatomical sex. It is classified in different subgroups based on the patient’s karyotype, gonadal dysgenesis, and the appearance of…
View article: Erratum zu: Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion
Erratum zu: Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion Open
View article: Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion
Nekrotisierende Pneumonie durch Panton-Valentin-Leukozidin(PVL)-positiven Staphylococcus aureus nach Parainfluenza-2-Infektion Open