Steffen Ormanns
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View article: Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion
Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion Open
Background Colorectal cancer liver metastasis (CRLM) is associated with poor survival, primarily due to acquired therapy resistance. While novel therapies arise, translation is limited by the lack of tumor models accurately representing dy…
View article: Diagnostic accuracy and Patient Derived Organoid (PDO) yield of 19G vs 22G Franseen needles for EUS-Guided biopsy in solid pancreatic lesions: A prospective comparative study
Diagnostic accuracy and Patient Derived Organoid (PDO) yield of 19G vs 22G Franseen needles for EUS-Guided biopsy in solid pancreatic lesions: A prospective comparative study Open
Compared to 22G, the 19G- FNB needle did not provide higher diagnostic accuracy or PDO yield, suggesting no need for larger needle sizes for PDO generation.
View article: Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival
Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival Open
Inflammatory cardiovascular diseases are the leading cause of death worldwide. Neutrophils, key drivers during inflammation, have consistently been associated with adverse outcomes and mortality in cardiovascular pathologies. Given the uni…
View article: FGFR1/3 Signaling as an Achilles’ Heel of Phenotypic Diversity in Urothelial Carcinoma
FGFR1/3 Signaling as an Achilles’ Heel of Phenotypic Diversity in Urothelial Carcinoma Open
FGFR inhibitors are a new therapeutic option for urothelial carcinoma (UC) with FGFR2/3 alterations. In this study, we analyzed genetic alterations, co-regulation, and differential expression for 45 genes encoding FGF, FGFR, or FGF-binding…
View article: IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases Open
View article: PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer
PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer Open
To grow at distant sites, metastatic cells must overcome major challenges posed by the unique cellular and metabolic composition of secondary organs 1 . Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that metastasizes to …
View article: Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival
Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival Open
Inflammatory cardiovascular diseases are the leading cause of death worldwide. Neutrophils, key drivers during inflammation, have consistently been associated with adverse outcomes and mortality in cardiovascular pathologies. Given the uni…
View article: Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies Open
View article: IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases Open
Multi-omic and multimodal datasets with detailed clinical annotations offer significant potential to advance our understanding of inflammatory bowel diseases (IBD), refine diagnostics, and enable personalized therapeutic strategies. In thi…
View article: The Prognostic, Predictive and Clinicopathological Implications of KRT81/HNF1A- and GATA6-Based Transcriptional Subtyping in Pancreatic Cancer
The Prognostic, Predictive and Clinicopathological Implications of KRT81/HNF1A- and GATA6-Based Transcriptional Subtyping in Pancreatic Cancer Open
Background: Transcriptional subtypes of pancreatic ductal adenocarcinoma (PDAC) based on the expression of hallmark genes may have prognostic implications and potential predictive functions. The two most employed subtyping markers assess t…
View article: Supplementary Table S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S5
View article: Supplementary Figure S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
CD38 and FoxP3 cells surround B-cell clusters in TLS.
View article: Supplementary Figure S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
TLS in PDAC patients are active germinal centers.
View article: Supplementary Figure S7 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S7 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Germinal center markers are expressed in lymphoid follicles.
View article: Supplementary Figure S10 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S10 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Physicochemical properties of CDRH3s and VH gene segment mutation frequencies
View article: Supplementary Table S4 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S4 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S4
View article: Supplementary Figure S11 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S11 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Example sequence alignments
View article: Supplementary Figure S6 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S6 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
T cells surround B-cell cluster in PDAC TLS.
View article: Supplementary Figure S9 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S9 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Next-generation sequencing (NGS) read characteristics
View article: Supplementary Table S2 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S2 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S2
View article: Supplementary Table S3 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S3 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S3
View article: Supplementary Figure S2 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S2 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Schematic overview laser microdissection
View article: Supplementary Figure S3 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S3 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Gene expression TLS-high vs. TLS-low tumor tissue
View article: Supplementary Table S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S1
View article: Supplementary Figure S8 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S8 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
PDAC patients show activated or non-activated tumor draining lymph nodes.
View article: Supplementary Figure S4 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S4 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
C3 expression in TLS-high patients
View article: Data from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Data from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation that are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pan…
View article: Supplementary Table 6 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches
Supplementary Table 6 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches Open
Supplementary Table 6.overall_survival
View article: Supplementary Table 3 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches
Supplementary Table 3 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches Open
Supplementary Table 3.ttest_basalclassical
View article: Supplementary Table 7 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches
Supplementary Table 7 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches Open
Supplementary Table 7.response