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Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion Open

Xiaobo Wang, Rouzanna Istvánffy, Linhan Ye, Steffen Teller, Melanie Laschinger , et al. · 2023

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled i…

Supplementary figure legends from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary figure legends

Data from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Purpose:Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenviro…

Supplementary figure legends from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary figure legends

Supplementary figures from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary Figure 1. Object-based automated detection analysis of immune cell infiltration in human PCa with CellProfiler Software. Supplementary Figure 2. Automated analysis of the angiogenesis and stromal activation in PCa. Supplement…

Supplementary figures from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary Figure 1. Object-based automated detection analysis of immune cell infiltration in human PCa with CellProfiler Software. Supplementary Figure 2. Automated analysis of the angiogenesis and stromal activation in PCa. Supplement…

Supplementary tables 1-5 from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary Table 1. Clinical characteristics of neoadjuvantly treated vs upfront resected PDAC patients and the types of neoadjuvant regimens. Supplementary Table 2. Specifications and dilutions of the primary antibodies used in our exp…

Data from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Purpose:Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenviro…

Supplementary tables 1-5 from Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2023

Supplementary Table 1. Clinical characteristics of neoadjuvantly treated vs upfront resected PDAC patients and the types of neoadjuvant regimens. Supplementary Table 2. Specifications and dilutions of the primary antibodies used in our exp…

One‐Year Landmark Analysis of the Effect of Beta‐Blocker Dose on Survival After Acute Myocardial Infarction Open

Jeffrey J. Goldberger, Haris Subačius, Oscar C. Marroquin, Scott L. Beau, Jay Simonson , et al. · 2021

Background Although beta‐blockers are recommended following myocardial infarction (MI), the benefits of long‐term treatment have not been established. The study's aim was to evaluate beta‐blocker efficacy by dose in 1‐year post‐MI survivor…

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation Open

Paulo L. Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik , et al. · 2020

Background: Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progress…

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation Open

Paulo L. Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik , et al. · 2020

Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology Open

Karin Feldmann, H. Carlo Maurer, Katja Peschke, Steffen Teller, Kathleen Schuck , et al. · 2020

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation Open

Paulo L. Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik , et al. · 2020

Background Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progressi…

Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation Open

Ömer Cemil Saricaoglu, Steffen Teller, Xiaobo Wang, Shenghan Wang, Pavel Stupakov , et al. · 2020

Background Neuropathy and neuro‐inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced‐mouse models, have been increasingly utilized in mechanist…

Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells Open

Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak , et al. · 2019

Purpose: Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvir…

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis Open

İhsan Ekin Demir, Tobias Heinrich, Dominique G. Carty, Ömer Cemil Saricaoglu, Sarah Klauss , et al. · 2019

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells Open

İhsan Ekin Demir, Kristina Kujundzic, Paulo L. Pfitzinger, Ömer Cemil Saricaoglu, Steffen Teller , et al. · 2016

Significance Pancreatic ductal adenocarcinoma cancer (PDAC) cells have an exceptional propensity to invade nerves via pronounced crosstalk between nerves and cancer cells, but the mechanisms of this early neural invasion are yet unknown. B…

Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer Open

Ujjwal Mukund Mahajan, Steffen Teller, Matthias Sendler, Raghavendra Palankar, Cindy van den Brandt , et al. · 2016

Our data suggest siPLK1-StAv-SPIONs with dual specificity residues for tumour targeting and membrane translocation to represent an exciting opportunity for targeted therapy in patients with PDAC.

Neurogenesis and angiogenesis in pancreatic cancer evolve concordantly via distinct transcriptional profiles Open

İbrahim Demir, Isabel Kröger, Steffen Teller, Helmut Friess, G.O. Ceyhan · 2016

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia Open

İhsan Ekin Demir, Elke Tieftrunk, Stephan Schorn, Ömer Cemil Saricaoglu, Paulo L. Pfitzinger , et al. · 2016

Objective The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal…

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