Stefanie Pratt
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Resolution of sustained ventricular tachycardia in a horse presenting with colic with magnesium sulfate Open
Summary Case reports demonstrating a return to sinus rhythm from sustained ventricular tachycardia (VT) are limited. VT is uncommon in horses but can be life threatening and has been reported in horses with primary gastrointestinal disease…
Does lesion type or severity predict outcome of therapy for horses with equine glandular gastric disease? – A retrospective study Open
Background Equine glandular gastric disease (EGGD) is a common condition of the horse. Misoprostol is reported to be superior to oral omeprazole and sucralfate for treatment. Long‐acting intramuscular injectable omeprazole (LAIOMEP) is a n…
Assessment of agreement using the equine glandular gastric disease grading system in 84 cases Open
Introduction Equine glandular gastric disease (EGGD) is a common condition causing signs of gastric pain although lesions are highly variable in their appearance. The only definitive method to diagnose EGGD ante‐mortem is gastroscopy. The …
View article: Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using<i>in vitro</i>systems
Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using<i>in vitro</i>systems Open
Horses are exposed to various kinds of medication, however, there are limited determinations of plasma clearance (CLp) for the drugs used due to the high cost of equine in vivo studies.Many of the CLp values generated come from the equine …
View article: The effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse
The effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse Open
1. Scaling factor values for the in vitro-in vivo extrapolation of hepatic metabolic clearance for xenobiotics have not yet been determined in horses. Scaling factors were determined by comparing the total protein and or cytochrome (CYP) P…
View article: Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies
Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies Open
Despite reports of the successful isolation of primary equine hepatocytes, there are no published data regarding the successful cryopreservation of these isolated cells. In this study, a detailed description of the procedures for isolation…