Stella E. Lee
YOU?
Author Swipe
View article: Update on the Nasal Polyp Score
Update on the Nasal Polyp Score Open
View article: Respiratory viral infection is associated with increased <i>Pseudomonas</i> abundance in cystic fibrosis airways
Respiratory viral infection is associated with increased <i>Pseudomonas</i> abundance in cystic fibrosis airways Open
Acute respiratory viral infections are an important driver of morbidity and mortality in people with chronic lung disease and are frequently associated with pulmonary exacerbations and a transition from intermittent to chronic bacterial in…
View article: Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects
Characterizing everyday exposure to volatile organic compounds and upper respiratory health effects Open
Volatile organic compounds (VOCs) are relatively understudied pollutants compared to particulate matter but are ubiquitous in outdoor and indoor environments. Prior studies on VOCs on sinonasal health have been difficult to generalize due …
View article: Forever Chemicals: An Exploratory, Population-Based Analysis of Per- and Polyfluoroalkyl Substances Exposure and Effects on Sinonasal Health
Forever Chemicals: An Exploratory, Population-Based Analysis of Per- and Polyfluoroalkyl Substances Exposure and Effects on Sinonasal Health Open
View article: Students' Insights into the Libraries
Students' Insights into the Libraries Open
This article presents a forward-looking perspective on the evolution of libraries over the next century, focusing on the integration of advanced technology and the preservation of traditional library elements. Drawing from personal experie…
View article: Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling
Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling Open
Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), s…
View article: Air pollution exposure and head and neck cancer incidence
Air pollution exposure and head and neck cancer incidence Open
To investigate air pollution's effect in the form of PM2.5 (particulate matter measuring less than 2.5 microns) on head and neck aerodigestive cancer incidence, an epidemiological cohort analysis was performed using data from th…
View article: Making “scents” of nutrients: Investigating the relationship between olfactory dysfunction and vitamin intake
Making “scents” of nutrients: Investigating the relationship between olfactory dysfunction and vitamin intake Open
Key points Decreased overall dietary consumption of micronutrients may be linked to an increased risk of olfactory dysfunction (OD) including subjective report of OD, subjective report of phantosmia, and objective OD. Interactions were ide…
View article: Reduced Sense of Smell in Patients with Severe Chronic Rhinosinusitis and its Implications for Diagnosis and Management: A Narrative Review
Reduced Sense of Smell in Patients with Severe Chronic Rhinosinusitis and its Implications for Diagnosis and Management: A Narrative Review Open
View article: IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis despite Modulator Therapy
IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis despite Modulator Therapy Open
"IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis Despite Modulator Therapy." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Dupilumab response onset, maintenance, and durability in patients with severe CRSwNP
Dupilumab response onset, maintenance, and durability in patients with severe CRSwNP Open
Most patients with CRSwNP achieve clinically meaningful responses to dupilumab by week 16, and most such patients in our study had maintenance and durability of response with continued treatment over time.
View article: Human nasal epithelial cells express <scp>IL</scp>‐<scp>5Rα</scp> but not the co‐receptor <scp>CSF2RB</scp> and do not signal to <scp>IL</scp>‐5
Human nasal epithelial cells express <span>IL</span>‐<span>5Rα</span> but not the co‐receptor <span>CSF2RB</span> and do not signal to <span>IL</span>‐5 Open
The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information sup…
View article: Cystic fibrosis pathogens persist in the upper respiratory tract following initiation of elexacaftor/tezacaftor/ivacaftor therapy
Cystic fibrosis pathogens persist in the upper respiratory tract following initiation of elexacaftor/tezacaftor/ivacaftor therapy Open
Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in C…
View article: Adult-onset asthma, allergy, and aspirin hypersensitivity associate with self-reported food avoidance
Adult-onset asthma, allergy, and aspirin hypersensitivity associate with self-reported food avoidance Open
Our study shows a positive association between avoidance diets and adult-onset asthma, and with allergic disease or AERD within asthmatic patients. Although we lack information on the reason patients chose to observe a specific diet, our r…
View article: TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases Open
View article: Persistence and evolution of <i>Pseudomonas aeruginosa</i> following initiation of highly effective modulator therapy in cystic fibrosis
Persistence and evolution of <i>Pseudomonas aeruginosa</i> following initiation of highly effective modulator therapy in cystic fibrosis Open
Today, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is wide…
View article: Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis
Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis Open
Background While the widespread initiation of elexacaftor/tezacaftor/ivacaftor (ETI) has led to dramatic clinical improvements among persons with cystic fibrosis (pwCF), little is known about how ETI affects the respiratory mucosal inflamm…
View article: Impact of Dupilumab on Sinonasal Symptoms and Outcomes in Severe Chronic Rhinosinusitis With Nasal Polyps
Impact of Dupilumab on Sinonasal Symptoms and Outcomes in Severe Chronic Rhinosinusitis With Nasal Polyps Open
Objectives To assess the severity of the top 5 22‐item Sino‐Nasal Outcome Test (SNOT‐22) items ranked most important by patients with chronic rhinosinusitis with nasal polyps (CRSwNP), the effect of dupilumab on these items, and their asso…
View article: Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease
Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease Open
View article: Elexacaftor–tezacaftor–ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis
Elexacaftor–tezacaftor–ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis Open
Background Chronic rhinosinusitis (CRS) is common in individuals with cystic fibrosis (CF) and is marked by chronic inflammation and episodes of infection that negatively impact quality of life. Several studies have shown that elexacaftor–…
View article: Not just snot: Local inflammatory profiles in patients with aspirin‐exacerbated respiratory disease differ from patients with aspirin‐tolerant chronic rhinosinusitis
Not just snot: Local inflammatory profiles in patients with aspirin‐exacerbated respiratory disease differ from patients with aspirin‐tolerant chronic rhinosinusitis Open
Key Points IL‐5, CCL2, and CXCL8 in sinus mucous are higher in patients with AERD relative to aspirin‐tolerant patients with CRS These mediators are pleiotropic, leading to widescale inflammatory processes contributing to AERD AERD is not …
View article: International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023 Open
Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐A…
View article: Iron bioavailability regulates Pseudomonas aeruginosa interspecies interactions through type VI secretion expression
Iron bioavailability regulates Pseudomonas aeruginosa interspecies interactions through type VI secretion expression Open
The cystic fibrosis (CF) respiratory tract harbors pathogenic bacteria that cause life-threatening chronic infections. Of these, Pseudomonas aeruginosa becomes increasingly dominant with age and is associated with worsening lung function a…
View article: <i>AJRA</i> Special Issue on Nasal Polyps
<i>AJRA</i> Special Issue on Nasal Polyps Open
View article: Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study
Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study Open
Background Although the psychometric properties of patient-reported outcome measures (e.g. the 22-item Sino-nasal Outcomes Test [SNOT-22]) in chronic rhinosinusitis with nasal polyps (CRSwNP) have been defined, these definitions have not b…
View article: Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study
Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study Open
Importance Currently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemente…
View article: Dupilumab provides early and durable improvement of symptoms in patients with chronic rhinosinusitis with nasal polyps
Dupilumab provides early and durable improvement of symptoms in patients with chronic rhinosinusitis with nasal polyps Open
Objectives To evaluate within‐patient symptom improvement in the dupilumab SINUS‐24/‐52 studies in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) (NCT02912468/NCT02898454). Methods Patients received dupilumab 300 mg…
View article: Human Intraepithelial Mast Cell Differentiation and Effector Function Are Directed by TGF-β&nbsp;Signaling
Human Intraepithelial Mast Cell Differentiation and Effector Function Are Directed by TGF-β Signaling Open
View article: Olfactory and neurological outcomes of SARS-CoV-2 from acute infection to recovery
Olfactory and neurological outcomes of SARS-CoV-2 from acute infection to recovery Open
Educational objective To investigate the impact of SARS-CoV-2 on sinonasal quality of life, olfaction, and cognition at different stages of viral infection and evaluate the association between olfaction and cognition in this population coh…
View article: Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis
Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis Open
Together with prior sinus microbiota studies of adults with CF chronic rhinosinusitis, our study underscores similarities between sinus and lower respiratory tract microbial community structures in CF. We show how community structure track…