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Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during <i>Nippostrongylus brasiliensis</i> infection Open

Pedro H. Papotto, James E Parkinson, Brian H. K. Chan, I‐Hsuan Lin, Gayle Cocita Baldwin , et al. · 2025

Many helminth parasites migrate through multiple host organs during infection but how immune responses are relayed across these tissues is still poorly understood. To investigate the cellular and molecular aspects of inter-tissue communica…

The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration Open

Jesuthas Ajendra, Pedro H. Papotto, James E Parkinson, Rebecca J. Dodd, André Luís Bombeiro , et al. · 2023

Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients Open

Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary , et al. · 2023

Myelofibrosis is a myeloproliferative neoplasm (MPN) which typically results in reduced length and quality of life due to systemic symptoms and blood count changes arising from fibrotic changes in the bone marrow. While the JAK2 inhibitor …

Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 4 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 4. Significantly changed proteins in heatmap.

Additional file 8 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 8. Differentially expression mucus proteins in UIP versus Mucinous Adenocarcinoma.

Additional file 5 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 5. A list of proteins detected in UIP and Mucinous Adenocarcinoma mucus.

Additional file 6 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 6. A list of mucus protein intensity levels.

Additional file 2 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 2. A list of detected airway proteins.

Additional file 3 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 3. Differentially expressed airway proteins.

Additional file 7 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open

Jeremy Herrera, Lewis Dingle, M. Angeles Monetero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2023

Additional file 7. A list of mucus secretome associated proteins.

IL-17A promotes epithelial cell IL-33 production during nematode lung migration Open

Jesuthas Ajendra, Stella Pearson, James E Parkinson, Brian H. K. Chan, Henry J. McSorley , et al. · 2022

The early migratory phase of pulmonary helminth infections is characterized by tissue injury leading to the release of the alarmin IL-33 and subsequent induction of type 2 immune responses. We recently described a role for IL-17A, through …

The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia Open

Jeremy Herrera, Lewis Dingle, M. Angeles Montero, Rajamiyer Venkateswaran, John Blaikley , et al. · 2022

Honeycombing (HC) is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). HC refers to cystic airways (HC airways) located at sites of dense fibrosis with marked mucus accumulation. Utilizing laser capture microdissec…

Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells Open

Stella Pearson, Anthony D. Whetton, Andrew Pierce · 2022

Despite the big increase in precision medicine targeted therapies developing curative treatments for many cancers is still a major challenge due mainly to the development of drug resistance in cancer stem cells. The cancer stem cells are c…

The magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB/c <i>versus</i> C57BL/6 mice but matrix composition differs Open

James E Parkinson, Stella Pearson, Dominik Rückerl, Judith E. Allen, Tara E. Sutherland · 2021

Allergic airway inflammation is heterogeneous with variability in immune phenotypes observed across asthmatic patients. Inflammation has been thought to directly contribute to airway remodeling in asthma, but clinical data suggest that neu…

The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differs Open

James E Parkinson, Stella Pearson, Dominik Rückerl, Judith E. Allen, Tara E. Sutherland · 2020

Allergic airway inflammation is heterogenous with variability in immune phenotypes observed across asthmatic patients. Inflammation has been thought to directly contribute to airway remodelling in asthma, but clinical data suggests that ne…

EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal Open

Roberto Paredes, James R. Kelly, Bethany Geary, Batool Almarzouq, Marion Schneider , et al. · 2020

The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To investigate the effects of post-…

EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle Open

Roberto Paredes, Marion Schneider, Stella Pearson, Hsiang Yin Teng, James R. Kelly , et al. · 2020

Aberrantly high expression of EVI1 in acute myeloid leukaemia (AML) is associated with poor prognosis. For targeted treatment of EVI1 overexpressing AML a more detailed understanding of aspects of spatiotemporal interaction dynamics of the…

IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection Open

Jesuthas Ajendra, Alistair Chenery, James E Parkinson, Brian H. K. Chan, Stella Pearson , et al. · 2020

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type-2 immune response to nematode infection Open

Jesuthas Ajendra, Alistair Chenery, James E Parkinson, Brian H. K. Chan, Stella Pearson , et al. · 2019

Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production and neutrophilia. Using N. brasiliensis infection we confirm previous observations that Il1…

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia Open

Stella Pearson, Baoqiang Guo, Andrew Pierce, Narges Azadbakht, Julie Brazzatti , et al. · 2019

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of early childhood with a poor survival rate, thus there is a requirement for improved treatment strategies. Induced pluripotent stem cells offer the abil…

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells Open

Stella Pearson, Rognvald Blance, Tim C. P. Somervaille, Anthony D. Whetton, Andrew Pierce · 2019

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EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association Open

Roberto Paredes, Marion Schneider, Adam Stevens, Daniel J. White, Andrew J.K. Williamson , et al. · 2018

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association Open

Roberto Paredes, Marion Schneider, Adam Stevens, Daniel J. White, Andrew J.K. Williamson , et al. · 2018

The transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and so…

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches Open

Stella Pearson, Andrew J.K. Williamson, R Blance, Tim C. P. Somervaille, Samuel J. Taylor , et al. · 2017

MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis <i>via</i> phosphorylation of THOC5 Open

Anthony D. Whetton, Norhaida Che Azmi, Stella Pearson, Ewa Jaworska, Liqun Zhang , et al. · 2016

The thrombopoietin receptor (MPL) has been shown to be mutated (MPL W515L) in myelofibrosis and thrombocytosis yet new approaches to treat this disorder are still required. We have previously shown that transcriptome and proteomic effects …

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood Open

Manuela Piazzi, Andrew J.K. Williamson, Chia-Fang Lee, Stella Pearson, Georges Lacaud , et al. · 2015

Murine embryonic stem (ES) cells can differentiate in vitro into three germ layers (endodermic, mesodermic, ectodermic). Studies on the differentiation of these cells to specific early differentiation stages has been aided by an ES cell li…

In Vivo Repopulating Activity Emerges at the Onset of Hematopoietic Specification during Embryonic Stem Cell Differentiation Open

Stella Pearson, Sara Cuvertino, Maud Fleury, Georges Lacaud, Valérie Kouskoff · 2015

The generation of in vivo repopulating hematopoietic cells from in vitro differentiating embryonic stem cells has remained a long-standing challenge. To date, hematopoietic engraftment has mostly been achieved through the enforced expressi…

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