Hyunjung Shin
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View article: Synergistic Bone Regeneration Through Sequential Dual-drug Delivery
Synergistic Bone Regeneration Through Sequential Dual-drug Delivery Open
The global aging population has raised concerns regarding age-related health issues like osteoporosis and bone fractures. To address these conditions, bone-like scaffolds containing bioactive molecules and biomaterials have been widely stu…
View article: NeuroFANN: identification of neuropathological subtypes in dementia with plasma proteins by using functionally annotated neural network
NeuroFANN: identification of neuropathological subtypes in dementia with plasma proteins by using functionally annotated neural network Open
Dementia diagnosis relies on identifying neuropathological features, such as beta-amyloid (Aβ) deposition, medial temporal lobe atrophy (MTA), and white matter hyperintensity (WMH). Recently, plasma protein biomarkers have emerged as a cos…
View article: PPIxGPN: plasma proteomic profiling of neurodegenerative biomarkers with protein–protein interaction-based eXplainable graph propagational network
PPIxGPN: plasma proteomic profiling of neurodegenerative biomarkers with protein–protein interaction-based eXplainable graph propagational network Open
Neurodegenerative diseases involve progressive neuronal dysfunction, requiring the identification of specific pathological features for accurate diagnosis. While cerebrospinal fluid analysis and neuroimaging are commonly used, their invasi…
View article: Identification of molecular subtypes of dementia by using blood-proteins interaction-aware graph propagational network
Identification of molecular subtypes of dementia by using blood-proteins interaction-aware graph propagational network Open
Plasma protein biomarkers have been considered promising tools for diagnosing dementia subtypes due to their low variability, cost-effectiveness, and minimal invasiveness in diagnostic procedures. Machine learning (ML) methods have been ap…
View article: NetPRISBI‐AD: Network‐based Polygenic Risk Scoring model with Brain Imaging for Alzheimer’s Disease
NetPRISBI‐AD: Network‐based Polygenic Risk Scoring model with Brain Imaging for Alzheimer’s Disease Open
Background The amount of gray matter can measure the structural characteristics of the brain, and the deterioration of brain function can be evaluated accordingly. In particular, the lower the amount of gray matter in areas involved in mem…
View article: Impact of the Robotics Industry in the Local Governments - Focusing on Regional Productivity and Employment Competitiveness -
Impact of the Robotics Industry in the Local Governments - Focusing on Regional Productivity and Employment Competitiveness - Open
When the population outflow from local governments in Korea is intensifying and the aging population and job shortages are increasing, it is significant to examine the impact of the robotics industry on the local economy.Therefore, this st…
View article: Clinicopathological and Genetic Characteristics of Patients of Different Ages with Diffuse Sclerosing Variant Papillary Thyroid Carcinoma
Clinicopathological and Genetic Characteristics of Patients of Different Ages with Diffuse Sclerosing Variant Papillary Thyroid Carcinoma Open
Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is commonly observed in young patients, with a median age at diagnosis in the third decade of life. Further, the risk of recurrence is higher for DSVPTC than for classical PTC…
View article: Lazy Node-Dropping Autoencoder
Lazy Node-Dropping Autoencoder Open
International audience
View article: Fast Integration for Multiple Graphs with Neumann Approximation
Fast Integration for Multiple Graphs with Neumann Approximation Open
International audience
View article: Fast Prediction for Suspect Candidates from Criminal Networks
Fast Prediction for Suspect Candidates from Criminal Networks Open
International audience
View article: Fast Prediction for Criminal Suspects through Neighbor Mutual Information‐Based Latent Network
Fast Prediction for Criminal Suspects through Neighbor Mutual Information‐Based Latent Network Open
One of the interesting characteristics of crime data is that criminal cases are often interrelated. Criminal acts may be similar, and similar incidents may occur consecutively by the same offender or by the same criminal group. Among many …
View article: Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data
Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data Open
Motivation Understanding comorbidity is essential for disease prevention, treatment and prognosis. In particular, insight into which pairs of diseases are likely or unlikely to co-occur may help elucidate the potential relationships betwee…
View article: Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer’s Disease Study: BICWALZS
Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer’s Disease Study: BICWALZS Open
Objective We aimed to present the study design and baseline cross-sectional participant characteristics of biobank innovations for chronic cerebrovascular disease with Alzheimer’s disease study (BICWALZS) participants.Methods A total of 1,…
View article: Vacuum Leak Detection Method Using Index Regression and Correction for Semiconductor Equipment in a Vacuum Chamber
Vacuum Leak Detection Method Using Index Regression and Correction for Semiconductor Equipment in a Vacuum Chamber Open
In semiconductor manufacturing, fault detection is an important method for monitoring equipment condition and examining the potential causes of a fault. Vacuum leakage is considered one of the major faults that can occur in semiconductor p…
View article: New approach of prediction of recurrence in thyroid cancer patients using machine learning
New approach of prediction of recurrence in thyroid cancer patients using machine learning Open
Although papillary thyroid cancers are known to have a relatively low risk of recurrence, several factors are associated with a higher risk of recurrence, such as extrathyroidal extension, nodal metastasis, and BRAF gene mutation. However,…
View article: Corrections to “Comorbidity Scoring With Causal Disease Networks”
Corrections to “Comorbidity Scoring With Causal Disease Networks” Open
Presents corrections to author information in the above named paper.
View article: Dementia key gene identification with multi-layered SNP-gene-disease network
Dementia key gene identification with multi-layered SNP-gene-disease network Open
Motivation Recently, various approaches for diagnosing and treating dementia have received significant attention, especially in identifying key genes that are crucial for dementia. If the mutations of such key genes could be tracked, it wo…
View article: Dementia Patient Segmentation Using EMR Data Visualization: A Design Study
Dementia Patient Segmentation Using EMR Data Visualization: A Design Study Open
(1) Background: The Electronic Medical Record system, which is a digital medical record management architecture, is critical for reliable medical research. It facilitates the investigation of disease patterns and efficient treatment via co…
View article: Inference on chains of disease progression based on disease networks
Inference on chains of disease progression based on disease networks Open
A disease network consisting of 3,302 diseases was constructed based on four sources of biomedical data: disease-protein relations, biological pathways, clinical history, and biomedical literature information. The last three sets of data c…
View article: Comorbidity of inflammatory bowel disease with atypical hemolytic uremic syndrome in pediatric patients
Comorbidity of inflammatory bowel disease with atypical hemolytic uremic syndrome in pediatric patients Open
Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy mediated by dysregulation of the alternative complement pathway. Complement-amplifying conditions such as respiratory and gastrointestinal infections, pregna…
View article: Cost for treatment and follow‐up of thyroid cancer increases according to the severity of disease
Cost for treatment and follow‐up of thyroid cancer increases according to the severity of disease Open
Background The aim of this study was to provide an analysis of thyroid cancer‐related health care costs over a 5‐year period, according to the extent of thyroid surgery. Methods The study included 33 patients from our institutional databas…
View article: Disease gene identification based on generic and disease-specific genome networks
Disease gene identification based on generic and disease-specific genome networks Open
Summary Immune diseases have a strong genetic component with Mendelian patterns of inheritance. While the tight association has been a major understanding in the underlying pathophysiology for the category of immune diseases, the common fe…