Stella Smith
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View article: Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis
Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis Open
To enhance the accuracy and validity of surveillance data for H. pylori in Africa, there is an urgent need for implementing standardized microbiological methods for resistance detection. The prevalence of CRHp reported in this study was ve…
View article: Assessment of awareness and levels of preparedness for humanitarian disasters across some geopolitical zones in Nigeria
Assessment of awareness and levels of preparedness for humanitarian disasters across some geopolitical zones in Nigeria Open
Background Disaster preparedness is critical for households, businesses, and communities. Over the years, Nigerians have had to rely on sheer luck and providence to save themselves from disasters with little or no help from rescue agencies…
View article: Genomic Analysis of Multidrug Resistant <i>Enterobacter hormaechei</i> Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria
Genomic Analysis of Multidrug Resistant <i>Enterobacter hormaechei</i> Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria Open
Enterobacter hormaechei has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomi…
View article: Sociodemographic and clinical factors influencing typhoid fever prevalence and multidrug resistance in Niger State, Nigeria.
Sociodemographic and clinical factors influencing typhoid fever prevalence and multidrug resistance in Niger State, Nigeria. Open
Among the 624 participants, typhoid fever prevalence was recorded at 36.5%, with young adults (ages 18-27) and semi-urban residents demonstrating higher infection rates. Antibiotic sensitivity testing revealed 98% resistance to amoxicillin…
View article: Genetic Determinants of Carbapenem and Fluoroquinolone Resistance in <i>Escherichia coli</i> Isolates of Clinical Origin
Genetic Determinants of Carbapenem and Fluoroquinolone Resistance in <i>Escherichia coli</i> Isolates of Clinical Origin Open
This study revealed a high level of resistance to fluoroquinolones, emphasizing the need for judicious use of antibiotics, particularly those with low resistance rates. Continuous surveillance is essential to monitor emerging trends in res…
View article: Expediting pathogen genomics adoption for enhanced foodborne disease surveillance in Africa
Expediting pathogen genomics adoption for enhanced foodborne disease surveillance in Africa Open
The role of genomics in public health surveillance has been accentuated by its crucial contributions during the COVID-19 pandemic, demonstrating its potential in addressing global disease outbreaks. While Africa has made strides in expandi…
View article: Assessment of Awareness and Level of Preparedness for Humanitarian Disasters in Nigeria
Assessment of Awareness and Level of Preparedness for Humanitarian Disasters in Nigeria Open
Background Disaster preparedness is critical for households, businesses, and communities. Over the years, Nigerians have had to rely on sheer luck and providence to save themselves from disasters with little or no help coming from rescue a…
View article: Alterations in the Gut Microbiota Composition and Structure of Children Under 5 Years With Sepsis: A Case Report From a Federal Medical Center in Lagos State, Nigeria
Alterations in the Gut Microbiota Composition and Structure of Children Under 5 Years With Sepsis: A Case Report From a Federal Medical Center in Lagos State, Nigeria Open
Background: Sepsis is a major cause of death among children in Sub-Saharan Africa. Although studies have suggested that the dysbiosis of the gut microbiota is associated with sepsis, there are limited data on the microbiota profile of chil…
View article: Genotypic and phenotypic characterization of determinants that mediate antimicrobial resistance in <i>Escherichia coli</i> strains of clinical origin in South-Western Nigeria
Genotypic and phenotypic characterization of determinants that mediate antimicrobial resistance in <i>Escherichia coli</i> strains of clinical origin in South-Western Nigeria Open
Background Multidrug resistant bacterial pathogens employ different mechanisms in evading the action of antibiotics. Multidrug resistance is wide spread among strains of Escherichia coli implicated in several infections including urinary t…
View article: Combatting anthrax outbreaks across Nigeria’s national land borders: need to optimize surveillance with epidemiological surveys
Combatting anthrax outbreaks across Nigeria’s national land borders: need to optimize surveillance with epidemiological surveys Open
Background Anthrax is a non-contagious zoonotic disease caused by the Gram-positive, spore-forming bacterium Bacillus anthracis . Infection is common in livestock and wild animals such as cattle, goats, sheep, camels, and antelopes. In hum…
View article: Campylobacter in Africa – A specific viewpoint
Campylobacter in Africa – A specific viewpoint Open
Campylobacter infections and campylobacteriosis-associated post-infectious sequelae are a significant global health burden that needs to be addressed from a specific African perspective. We conducted a comprehensive literature search on NC…
View article: Effect of selected disinfectants on biofilm-forming clinical isolates of Staphylococcus aureus in Lagos State, Nigeria
Effect of selected disinfectants on biofilm-forming clinical isolates of Staphylococcus aureus in Lagos State, Nigeria Open
Background and Aims: Staphylococcus aureus is one of the most important pathogens of public health concern and a leading cause of nosocomial infections. In this study, we evaluated the effect of routinely used disinfectants in hospitals fo…
View article: Antibiotic Resistance and Therapy for Helicobacter pylori Infection
Antibiotic Resistance and Therapy for Helicobacter pylori Infection Open
Approximately half of the world’s population is estimated to be infected with Helicobacter pylori [...]
View article: Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa Open
Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized no…
View article: Review of the prevalence, diagnostics, and containment measures of the current mpox outbreak
Review of the prevalence, diagnostics, and containment measures of the current mpox outbreak Open
Monkeypox (mpox), is a disease from the Poxviridae family that can cause several serious medical issues. This mini-review sought to analyze the existing literature regarding the current mpox outbreak with a focus on the prevalence, diagnos…
View article: Antibiotic Resistance and Plasmid Replicon Types of Non-Typhoidal <i>Salmonella</i> Serovars Isolated From Food Animals and Humans in Lagos, Nigeria
Antibiotic Resistance and Plasmid Replicon Types of Non-Typhoidal <i>Salmonella</i> Serovars Isolated From Food Animals and Humans in Lagos, Nigeria Open
Multidrug resistance and invasiveness of non-typhoidal Salmonella (NTS) serovars have in recent times brought to the fore the public health risk associated with salmonellosis. This study was aimed at profiling NTS serovars isolated from fo…
View article: Comparative Molecular Analysis and Antigenicity Prediction of an Outer Membrane Protein (ompC) of Non-typhoidal <i>Salmonella</i> Serovars Isolated from Different Food Animals in Lagos, Nigeria
Comparative Molecular Analysis and Antigenicity Prediction of an Outer Membrane Protein (ompC) of Non-typhoidal <i>Salmonella</i> Serovars Isolated from Different Food Animals in Lagos, Nigeria Open
Non-typhoidal Salmonella (NTS) infections occur globally with high morbidity and mortality. The public health challenge caused is exacerbated by increasing rate of antibiotic resistance and absence of NTS vaccine. In this study, we charact…
View article: SP5.2.5 Optimising Communication during Damage Control Surgery- a survey of adult Major Trauma Centres in England
SP5.2.5 Optimising Communication during Damage Control Surgery- a survey of adult Major Trauma Centres in England Open
Aims Snap briefs (truncated WHO checklists) and Sit Reps (situational reporting), are long established practices within the military, developed from their vast experience in treating patients requiring Damage Control Surgery (DCS)[1,2]. Ou…
View article: Perspective Chapter: SARS-CoV-2 Variants – Two Years Post-Onset of the Pandemic
Perspective Chapter: SARS-CoV-2 Variants – Two Years Post-Onset of the Pandemic Open
Since the pandemic began in China in December 2019, thousands of variants of SARS-CoV-2 have emerged globally since late 2020. The World Health Organization (WHO) defined the SARS-CoV-2 variant of concern (VOC) as a variant with increased …
View article: SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape Open
Omicron, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant that is now spreading across the world, is the most altered version to emerge so far, with mutations comparable to changes reported in earlier variants of co…
View article: COVID-19 and the Human Gut Microbiome: An Under-Recognized Association
COVID-19 and the Human Gut Microbiome: An Under-Recognized Association Open
Coronavirus disease 2019 (COVID-19) is an infectious disease with a wide range of respiratory and extrapulmonary symptoms, as well as gastrointestinal symptoms. Despite recent research linking gut microbiota to infectious diseases like inf…
View article: Assessment of potential factors that support the endemicity of cholera in Nigeria from food handlers, health workers and the environment
Assessment of potential factors that support the endemicity of cholera in Nigeria from food handlers, health workers and the environment Open
Background and Aims: Diarrheal diseases caused by bacterial pathogens are widespread and they result in morbidity and mortality of a lot of people yearly. The aim of this study was to assess the role of the environment, health workers and …
View article: Prevalence and Characterization of Methicillin-Resistant Staphylococcus aureus from Meat Retail Shops and Meat Handlers in the Buea Municipality, Cameroon
Prevalence and Characterization of Methicillin-Resistant Staphylococcus aureus from Meat Retail Shops and Meat Handlers in the Buea Municipality, Cameroon Open
Aim: Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious multidrug-resistant biovar of S. aureus associated with infections that result in high morbidity and mortality in humans and animals. Its persistence in both host and n…