Onur Boyman
YOU?
Author Swipe
View article: Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Supplementary Figures and Tables
View article: Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model
Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model Open
View article: Real-time visualization of STAT activation in live cells using genetically encoded biosensors
Real-time visualization of STAT activation in live cells using genetically encoded biosensors Open
Signal transducer and activator of transcription (STAT) is a family of key transcriptional regulators in immune, epithelial and mesenchymal cells. Aberrant STAT activity is associated with malignancy, autoimmunity and immunodeficiency. The…
View article: In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants
In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants Open
Interleukin-4 (IL-4) plays a central role in type 2 immune responses. Despite its potential use for allergic and autoimmune diseases, its pleiotropic receptor binding complicates selective targeting of IL-4 signaling pathways. We developed…
View article: IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer
IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer Open
View article: A systematic review of abatacept and belatacept in autoimmune disease
A systematic review of abatacept and belatacept in autoimmune disease Open
View article: Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model
Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model Open
The transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mous…
View article: Supplementary Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model
Supplementary Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model Open
Supplementary Figures and Tables
View article: Supplementary Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model
Supplementary Data from Tumor cell–intrinsic c-Myb upregulation stimulates antitumor immunity in a murine colorectal cancer model Open
Supplementary Figures and Tables
View article: Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation
Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation Open
Haemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory disorder often driven by dysfunctional cytotoxic CD8 + T cells, is marked by cytokine storms, which may follow viral infections. In a study of a perforin-defic…
View article: Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics
Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics Open
Due to its stimulatory potential for immunomodulatory CD4+ regulatory T (Treg) cells, low-dose interleukin-2 (IL-2) immunotherapy has gained considerable attention for the treatment of autoimmune diseases. In this investigator-i…
View article: In vitro and in vivo Evaluation of Chemically Synthesized, Receptor-Biased Interleukin-4 and Photocaged Variants
In vitro and in vivo Evaluation of Chemically Synthesized, Receptor-Biased Interleukin-4 and Photocaged Variants Open
Interleukin-4 (IL-4) is a cytokine that plays a central role in type 2 immune responses and is involved in regulating pleiotropic actions in our body by engaging multiple different IL-4 receptor (IL-4R) complexes. Targeting the IL-4R syste…
View article: IL-2 immunotherapy rescues irradiation-induced T cell exhaustion<i>in vivo</i>
IL-2 immunotherapy rescues irradiation-induced T cell exhaustion<i>in vivo</i> Open
Summary Radiotherapy (RT) can stimulate anti-cancer T cell responses that target primary and distant tumors. In addition to antigen-mediated stimulation of effector T cells, signals from stimulatory cytokines, notably interleukin-2 (IL-2),…
View article: Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid Open
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infectio…
View article: Optimising IL-2 for Cancer Immunotherapy
Optimising IL-2 for Cancer Immunotherapy Open
The key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor responses. However, total or partial …
View article: Figure 4 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 4 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Early c-Myb upregulation is crucial for control of tumor growth. A, Experimental setup. C57BL/6J mice were subcutaneously injected with MC38T/O cells and fed Ctrl or Dox chow. For two groups, chow is switched at day 14 fo…
View article: Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
The transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mous…
View article: Figure 4 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 4 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Early c-Myb upregulation is crucial for control of tumor growth. A, Experimental setup. C57BL/6J mice were subcutaneously injected with MC38T/O cells and fed Ctrl or Dox chow. For two groups, chow is switched at day 14 fo…
View article: Figure 6 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 6 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation regulates intrinsic changes in MC38 tumor cells that control tumor growth by CD8+ T cells. A, qRT-PCR data for B2m, antigen peptide transporter 2 (Tap2), CD137 ligand (Cd137L), C…
View article: Figure 1 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 1 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation reduces MC38 and B16-BL6 tumor growth in vivo. A, Immunofluorescence staining of c-Myb (red) in MC38T/O cells, treated for the indicated times with 1 μg/mL Dox in vitro. c-Myb staining is …
View article: Figure 6 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 6 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation regulates intrinsic changes in MC38 tumor cells that control tumor growth by CD8+ T cells. A, qRT-PCR data for B2m, antigen peptide transporter 2 (Tap2), CD137 ligand (Cd137L), C…
View article: Figure 3 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 3 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Tumor cell c-Myb upregulation results in changes in the TME. A and B, Flow cytometry analysis of subcutaneous MC38T/O tumors from Ctrl or Dox-treated mice at day 28 for CD103+ conventional DC (cDC); CD45…
View article: Figure 5 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 5 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation in MC38 tumor cells modulates genes involved in immune responses. A, Gene Ontology enrichment analysis of genes significantly dysregulated between tumor cells from mice on Dox- and Ctrl-chow using Enrichr tool (ht…
View article: Figure 2 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 2 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation does not alter MC38 intrinsic properties or tumor angiogenesis. A, C, and D, Representative images of Ki67 (A), cleaved caspase 3 (cCasp3; C, left) and CD31 (D, left) stained formalin-f…
View article: Figure 5 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 5 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation in MC38 tumor cells modulates genes involved in immune responses. A, Gene Ontology enrichment analysis of genes significantly dysregulated between tumor cells from mice on Dox- and Ctrl-chow using Enrichr tool (ht…
View article: Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
The transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mous…
View article: Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Supplementary Figures and Tables
View article: Figure 1 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 1 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
c-Myb upregulation reduces MC38 and B16-BL6 tumor growth in vivo. A, Immunofluorescence staining of c-Myb (red) in MC38T/O cells, treated for the indicated times with 1 μg/mL Dox in vitro. c-Myb staining is …
View article: Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Supplementary Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Supplementary Figures and Tables
View article: Figure 3 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Figure 3 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model Open
Tumor cell c-Myb upregulation results in changes in the TME. A and B, Flow cytometry analysis of subcutaneous MC38T/O tumors from Ctrl or Dox-treated mice at day 28 for CD103+ conventional DC (cDC); CD45…