Stephan Durot
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View article: Multi-omics analysis reveals metabolic diversity underlying endothelial cell functions
Multi-omics analysis reveals metabolic diversity underlying endothelial cell functions Open
Endothelial cells (ECs) line the vascular system and are key players in vascular homeostasis, yet their metabolic diversity across tissues, vascular beds, and growth states remains poorly understood. This study examines metabolic differenc…
Endothelial metabolic control of insulin sensitivity through resident macrophages Open
Endothelial cells (ECs) not only form passive blood conduits but actively contribute to nutrient transport and organ homeostasis. The role of ECs in glucose homeostasis is, however, poorly understood. Here, we show that, in skeletal muscle…
View article: c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs
c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs Open
Small intestinal villi are structural and functional units present in higher vertebrates and uniquely adapted to nutrient absorption. Villus enterocytes are organized in transcriptional “zones” dedicated to specialized tasks such as absorp…
View article: Epithelial-mesenchymal transition is the main driver of intrinsic metabolism in cancer cell lines
Epithelial-mesenchymal transition is the main driver of intrinsic metabolism in cancer cell lines Open
A fundamental feature of cancer cells is genomic heterogeneity. It is a main driver of phenotypic differences, including the response to drugs, and therefore a key factor in therapy selection. Motivated by the increasing role attributed to…
View article: FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure Open
Foxc2 sustains adult lymphatic vascular specialization and coordinates organ-specific lymph flow, gut microbiota, and inflammation.