Stephan Forchhammer
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View article: BAPoma, ein seltener Naevus als Schlüssel zur Diagnose des <i>BAP1</i> ‐assoziierten Tumorprädisposition‐Syndroms
BAPoma, ein seltener Naevus als Schlüssel zur Diagnose des <i>BAP1</i> ‐assoziierten Tumorprädisposition‐Syndroms Open
View article: Nested Melanoma and Superficial Spreading Melanoma with Prominent Nests—A Retrospective Study on Clinical Characteristics and PRAME Expression
Nested Melanoma and Superficial Spreading Melanoma with Prominent Nests—A Retrospective Study on Clinical Characteristics and PRAME Expression Open
Background: Nested melanoma is a rare subtype of superficial spreading melanoma. Due to its typical histology, characterized by the predominance of large melanocytic nests in an extensive horizontal spread, it is challenging to distinguish…
View article: Myeloid sarcoma shows a high frequency of mutations activating the <scp>MAPK</scp>/<scp>ERK</scp> pathway and association with clonal hematopoiesis
Myeloid sarcoma shows a high frequency of mutations activating the <span>MAPK</span>/<span>ERK</span> pathway and association with clonal hematopoiesis Open
Myeloid sarcoma (MS) is a mass‐forming extramedullary manifestation of myeloid blasts, either in relation to an underlying acute myeloid leukemia (AML), another myeloid neoplasm (MN) or as a de novo occurrence. Data on the genetic profile …
View article: Control of rapidly progressing melanoma metastases during pregnancy
Control of rapidly progressing melanoma metastases during pregnancy Open
View article: BAPoma, a rare nevus, as the key to a diagnosis of <i>BAP1</i> ‐associated tumor predisposition syndrome
BAPoma, a rare nevus, as the key to a diagnosis of <i>BAP1</i> ‐associated tumor predisposition syndrome Open
View article: The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at <scp>S102</scp> in colorectal cancer patients, stratified by <i>KRAS</i> mutational status and clinicopathological features
The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at <span>S102</span> in colorectal cancer patients, stratified by <i>KRAS</i> mutational status and clinicopathological features Open
Oncoprotein Y‐box‐binding protein‐1 (YB‐1) is involved in all cancer hallmarks. One of the most studied post‐translational modifications of YB‐1 is phosphorylation on Serine 102 (S102), which is involved in cancer progression. KRAS mutatio…
View article: Risk stratification using the Merlin Assay (CP-GEP) in an independent cohort of 930 patients with clinical stage I/II melanoma who did not undergo sentinel lymph node biopsy
Risk stratification using the Merlin Assay (CP-GEP) in an independent cohort of 930 patients with clinical stage I/II melanoma who did not undergo sentinel lymph node biopsy Open
This study shows that CP-GEP has the potential to stratify patients with early-stage melanoma who did not undergo SLNB based on their risk of recurrence. Patients with CP-GEP Low Risk have a significantly better long-term survival. CP-GEP …
View article: Preclinical <i>in vitro</i> and <i>in vivo</i> evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas
Preclinical <i>in vitro</i> and <i>in vivo</i> evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas Open
Background Prognosis and quality of life in patients with advanced cutaneous T-cell lymphoma (CTCL), particularly in those with Sézary syndrome (SS) or advanced-stage mycosis fungoides (MF), are poor. Monoclonal antibodies or antibody–drug…
View article: Challenges in developing a digital pathology consultation network: insights from the MELCAYA experience
Challenges in developing a digital pathology consultation network: insights from the MELCAYA experience Open
Objectives: The increasing adoption of Whole Slide Image (WSI) technology has created new opportunities for collaboration in diagnostic pathology. This study aims to describe the development, implementation, and challenges of establishing …
View article: ErbB receptor tyrosine kinase receptors as a therapeutic target in melanoma
ErbB receptor tyrosine kinase receptors as a therapeutic target in melanoma Open
View article: Expression and dimerization patterns of the ErbB receptor tyrosine kinase family in primary and metastatic cutaneous squamous cell carcinoma and their relationship with resistance to cetuximab
Expression and dimerization patterns of the ErbB receptor tyrosine kinase family in primary and metastatic cutaneous squamous cell carcinoma and their relationship with resistance to cetuximab Open
View article: Klinisch‐pathologische Merkmale Methotrexat‐induzierter epidermaler Dysmaturation: Eine Studie an 22 Patienten unter Niedrigdosistherapie
Klinisch‐pathologische Merkmale Methotrexat‐induzierter epidermaler Dysmaturation: Eine Studie an 22 Patienten unter Niedrigdosistherapie Open
Zusammenfassung Hintergrund und Ziele Haut‐ und Schleimhauterosionen mit histopathologischen Zeichen einer epidermalen Dysmaturation sind eine bekannte Nebenwirkung zytostatischer Chemotherapien, können aber auch unter niedrig dosierter Me…
View article: An Automated Real-Time PCR Assay versus Next-Generation Sequencing in the Detection of BRAF V600 Mutations in Melanoma Tissue Samples
An Automated Real-Time PCR Assay versus Next-Generation Sequencing in the Detection of BRAF V600 Mutations in Melanoma Tissue Samples Open
Background: Next-generation sequencing (NGS) is the most commonly used method for determining BRAF mutational status in patients with advanced melanoma. Automated PCR-based methods, such as the IdyllaTM system, are increasingly used for mu…
View article: Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study
Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study Open
Tumor-associated antigens (TAAs) are potential targets for T cell-based immunotherapy approaches in cutaneous melanoma. BNT111, an investigational lipoplex-formulated mRNA-based therapeutic cancer vaccine encoding melanoma TAAs NY-ESO-1, t…
View article: Successful treatment of Sneddon Syndrome with high dose intravenous immunoglobulin
Successful treatment of Sneddon Syndrome with high dose intravenous immunoglobulin Open
Sneddon Syndrome is an orphan disease characterized by the clinical presence of livedo racemosa and cerebrovascular ischaemia. Its pathophysiology remains inadequately understood and no validated treatment modality has been established. In…
View article: Migrating foreign body granulomas after rupture of a breast implant
Migrating foreign body granulomas after rupture of a breast implant Open
We present the case of an 80‐year‐old female with a history of bluish streaks and painful lumps on her left arm, initially misdiagnosed as a soft tissue infection. Further investigation revealed granulomatous infiltrates in the arm and a r…
View article: Patients’ and dermatologists’ preferences in artificial intelligence–driven skin cancer diagnostics: A prospective multicentric survey study
Patients’ and dermatologists’ preferences in artificial intelligence–driven skin cancer diagnostics: A prospective multicentric survey study Open
View article: A rare case of acute generalized exanthematous pustulosis induced by gadobutrol
A rare case of acute generalized exanthematous pustulosis induced by gadobutrol Open
We present a 50-year-old male, who was admitted to the hospital because of diffuse erythema with multiple non-follicular pustules beginning on the trunk and flexural areas with diffuse erythema and itching. The patient had undergone cerebr…
View article: Characterization of <scp>PRAME</scp> immunohistochemistry reveals lower expression in pediatric melanoma compared to adult melanoma
Characterization of <span>PRAME</span> immunohistochemistry reveals lower expression in pediatric melanoma compared to adult melanoma Open
Pediatric melanomas are rare tumors that have clinical and histological differences from adult melanomas. In adult melanoma, the immunohistochemical marker PRAME is increasingly employed as a diagnostic adjunct. PRAME is also under investi…
View article: Melanoma of the central nervous system based on neurocutaneous melanocytosis in childhood: A rare but fatal condition
Melanoma of the central nervous system based on neurocutaneous melanocytosis in childhood: A rare but fatal condition Open
Background Melanomas of the central nervous system (CNS) based on neurocutaneous melanocytosis (NCM) are exceptionally rare in childhood and have been described only sporadically. Rapidly progressive disease may represent a major challenge…
View article: Identification of patients at high risk for relapse by Merlin Assay (CP-GEP) in an independent cohort of patients with melanoma who did not undergo sentinel lymph node biopsy: head and neck subgroup analysis
Identification of patients at high risk for relapse by Merlin Assay (CP-GEP) in an independent cohort of patients with melanoma who did not undergo sentinel lymph node biopsy: head and neck subgroup analysis Open
View article: Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors Open
View article: Histopathologic regression in patients with primary cutaneous melanoma undergoing sentinel lymph node biopsy is associated with favorable survival and, after metastasis, with improved progression-free survival on immune checkpoint inhibitor therapy: A single-institutional cohort study
Histopathologic regression in patients with primary cutaneous melanoma undergoing sentinel lymph node biopsy is associated with favorable survival and, after metastasis, with improved progression-free survival on immune checkpoint inhibitor therapy: A single-institutional cohort study Open
Regression of cutaneous melanoma is associated with improved prognosis in patients eligible for SLN biopsy as well as in patients with unresectable disease receiving systemic therapy with immune checkpoint inhibitors.
View article: UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents
UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents Open
View article: Case Report: Paraneoplastic psoriasis in thymic carcinoma
Case Report: Paraneoplastic psoriasis in thymic carcinoma Open
Thymic carcinomas are exceedingly rare and very aggressive malignancies of the anterior mediastinum. While thymomas exhibit a high association with paraneoplastic syndromes, these phenomena are a rarity in thymic carcinomas. In general, ac…
View article: SARS-CoV-2–Induced Vasculitic Skin Lesions Are Associated with Massive Spike Protein Depositions in Autophagosomes
SARS-CoV-2–Induced Vasculitic Skin Lesions Are Associated with Massive Spike Protein Depositions in Autophagosomes Open
In patients infected with severe acute respiratory syndrome coronavirus 2, vasculopathic changes of the skin are associated with a severe prognosis. However, the pathogenesis of this vasculopathy is not conclusively clarified. In this stud…
View article: EGFR expression is associated with relapse in a melanoma cohort receiving adjuvant PD-1-based immunotherapy
EGFR expression is associated with relapse in a melanoma cohort receiving adjuvant PD-1-based immunotherapy Open
Adjuvant therapy with immune checkpoint inhibitors (ICIs) became standard for resected stage III/IV melanoma after the results from the CheckMate-238 and KEYNOTE-054 studies. However, 30% to 40% of patients relapse despite adjuvant therapy…
View article: Histopathologic abundance of pigmentation correlates with disease‐specific survival in malignant melanoma but is not independent of current <scp>AJCC pT</scp> stage
Histopathologic abundance of pigmentation correlates with disease‐specific survival in malignant melanoma but is not independent of current <span>AJCC pT</span> stage Open
The increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow‐up. The prognostic significance of tumor cell pigmentation has …
View article: Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases
Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases Open
See a detailed list of funding bodies in the Acknowledgements section at the end of the manuscript.
View article: Operative Therapie von Nävi bei Kindern in einem dermatochirurgischen Zentrum
Operative Therapie von Nävi bei Kindern in einem dermatochirurgischen Zentrum Open