Stephan M. Feller
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View article: Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals
Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals Open
While 3D electron diffraction (3D-ED or microcrystal electron diffraction; MicroED) has emerged as a promising method for protein structure determination, its applicability is hindered by a high susceptibility to radiation damage, leading …
View article: The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity
The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity Open
This work is the first to show a strong synergistic activity of Dasatinib in combination with clinically used glucocorticoids in solid tumors. Furthermore, the tyrosine kinase MET and its effector protein Gab1 are newly identified glucocor…
View article: A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein–Protein Interaction Implicated in Breast Cancer
A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein–Protein Interaction Implicated in Breast Cancer Open
Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strate…
View article: Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals
Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals Open
While 3D electron diffraction (3D-ED or microcrystal electron diffraction, MicroED) has emerged as a promising method for protein structure determination, its applicability is hindered by high susceptibility to radiation damage, leading to…
View article: Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1 Open
The non-receptor tyrosine phosphatase SHP2 (PTPN11) is a regulator of diverse cellular functions including mitogenic activation and cell migration. SHP2 consists of two tandem SH2 domains followed by the catalytic domain, and is autoinhibi…
View article: The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity
The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity Open
Background Tongue squamous cell carcinoma (TSCC) is an aggressive cancer associated with a poor prognosis and limited treatment options, necessitating new drug targets to improve therapeutic outcomes. Our current work focuses on protein ty…
View article: Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways
Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways Open
Isoforms of microtubule-associated protein 2 (MAP2) differ from their homolog Tau in the sequence and interactions of the N-terminal region. Binding of the N-terminal region of MAP2c (N-MAP2c) to the dimerization/docking domains of the reg…
View article: Self-assembly of Grb2 meshworks revealed by Grb2-Gab1<sub>497-528</sub>complex structure
Self-assembly of Grb2 meshworks revealed by Grb2-Gab1<sub>497-528</sub>complex structure Open
The ubiquitously expressed adaptor protein Growth factor receptor bound protein 2 (Grb2) plays an essential role in signal transduction by binding to activated receptor tyrosine kinases through its SH2 domain and to downstream effectors vi…
View article: Data from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer
Data from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer Open
Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for correct chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of many types of cancers. We investigated h…
View article: Supplementary Figure Legend from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Supplementary Figure Legend from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling Open
Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
View article: Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Data from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Data from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling Open
Drugs that inhibit insulin-like growth factor 1 (IGFI) receptor IGFIR were encouraging in early trials, but predictive biomarkers were lacking and the drugs provided insufficient benefit in unselected patients. In this study, we used genet…
View article: Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Sprouty2 is a feedback regulator that controls the Ras/Raf/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent …
View article: Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 3 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 2 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Tables S1-S8 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Supplementary Tables S1-S8 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling Open
Supplementary Tables S1-S8. S1: Antibodies used for western blotting, immunoprecipitation and immunofluorescence S2: siRNA libraries and individual siRNAs used in this study S3: Sequences of qPCR primers S4: Z' values in primary siRNA scre…
View article: Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Data from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Sprouty2 is a feedback regulator that controls the Ras/Raf/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent …
View article: Supplementary Figures S1-S6 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Supplementary Figures S1-S6 from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling Open
Supplementary Figures S1-S6. S1: Sensitivity to IGFâ€�1R inhibitor AZ12253801 is influenced by levels of DVL3 protein but not IGFâ€�1R or INSR S2: Effects of HUNK depletion on IGF signalling S3: Sensitivity to IGFâ€�1R inhibition is enhanc…
View article: Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Methods and References from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling
Supplementary Methods and References from Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling Open
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes supplementary references.
View article: Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Figure 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Data from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer
Data from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer Open
Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for correct chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of many types of cancers. We investigated h…
View article: Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Table 1 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation Open
Supplementary Methods, Legends for Figures 1-4 from Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation
View article: Supplemetal Material and Methods, Figure 1-7 and Table 1 from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer
Supplemetal Material and Methods, Figure 1-7 and Table 1 from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer Open
Supplemental Material and Methods. Supplemental Figure S1. Cell cycle analysis in FA and sporadic HNSCC cell lines upon ICL treatment. Supplemental Figure S2. FANCM protein expression is absent in FaDu cells. Supplemental Figure S3. Overvi…