Stephan Spahn
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View article: Lack of SLC26A9-mediated chloride secretion causes mucus plugging and severe respiratory distress in neonatal mice
Lack of SLC26A9-mediated chloride secretion causes mucus plugging and severe respiratory distress in neonatal mice Open
Solute carrier family 26, member 9 (SLC26A9) is an epithelial chloride channel that was identified as a genetic modifier of disease severity of cystic fibrosis (CF) and other chronic muco-obstructive lung diseases. However, data on the in …
View article: Lenvatinib after progression on pemigatinib and futibatinib in FGFR2 fusion-positive biliary tract cancer with an acquired kinase point mutation
Lenvatinib after progression on pemigatinib and futibatinib in FGFR2 fusion-positive biliary tract cancer with an acquired kinase point mutation Open
Biliary tract cancers (BTC) represent a heterogeneous group of malignancies with a poor prognosis and rising incidence. Oncogenic FGFR2 fusions are one of several actionable molecular alterations. In this context, selective FGFR tyrosine k…
View article: Case Report: FGFR2 inhibitor resistance via PIK3CA and CDKN2A/B in an intrahepatic cholangiocarcinoma patient with FGFR2-SH3GLB1 fusion
Case Report: FGFR2 inhibitor resistance via PIK3CA and CDKN2A/B in an intrahepatic cholangiocarcinoma patient with FGFR2-SH3GLB1 fusion Open
FGFR2 fusions occur in up to 14% of patients with intrahepatic cholangiocarcinoma (iCCA) and have been considered as therapeutic target for FGFR inhibitors (FGFRi). However, response to targeted treatment may be limited due to the emergenc…
View article: The prospective sonographic assessment of the lower uterine segment after cesarean section and its clinical utility
The prospective sonographic assessment of the lower uterine segment after cesarean section and its clinical utility Open
Purpose This study aims to investigate the sonographic features of the lower uterine segment (LUS) and their association with successful vaginal birth after a cesarean section (VBAC). Methods This is a prospective observational cohort stud…
View article: Unveiling Clinical Relevance: Investigating Placentas Submitted for Histological Examination and Their Correlation with Clinical Indications and Histological Findings
Unveiling Clinical Relevance: Investigating Placentas Submitted for Histological Examination and Their Correlation with Clinical Indications and Histological Findings Open
In Germany, there is currently no official guideline for the submission of placentas for histopathological examination. Placentas are sent for histological examination by obstetricians according to locally defined indications, which leads …
View article: THE MOLECULAR INTERACTION PATTERN OF LENVATINIB ENABLES INHIBITION OF WILD-TYPE OR KINASE-MUTATED FGFR2-DRIVEN CHOLANGIOCARCINOMA
THE MOLECULAR INTERACTION PATTERN OF LENVATINIB ENABLES INHIBITION OF WILD-TYPE OR KINASE-MUTATED FGFR2-DRIVEN CHOLANGIOCARCINOMA Open
Enclosed are the molecular dynamics simulations of drug–FGFR2 systems and the MM-GBSA raw data. The zip archives include the molecular dynamics trajectory files in Desmond Maestro format (*_trj; *-out.cms), the naming of zip archives is as…
View article: Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects
Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects Open
The host microbiome is polymorphic, compartmentalized, and composed of distinctive tissue microbiomes. While research in the field of cancer immunotherapy has provided an improved understanding of the interaction with the gastrointestinal …
View article: Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to <scp>HSV1</scp> primary infection
Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to <span>HSV1</span> primary infection Open
Herpes simplex virus 1 (HSV‐1) is a frequently unrecognized, yet deadly cause of acute liver failure (ALF). We, therefore, analysed three cases of fatal HSV‐1‐induced ALF. All patients shared clinical (extremely elevated transaminases, LDH…
View article: Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma
Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions. In addition to fusions, a considerable fraction of iCCA patients reveals FGFR2 mut…
View article: Management of bicornuate uterus non-communicating rudimentary uterine horn: A case report
Management of bicornuate uterus non-communicating rudimentary uterine horn: A case report Open
A pregnancy in a non-communicant rudimentary horn is a rare but serious complication. Patients with bicornuate uterus non-communicating have an increased risk of obstetrical complications, such as abortion, intrauterine growth restriction,…
View article: Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma
Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma Open
Immune checkpoint inhibitors (ICIs) belong to the therapeutic armamentarium in advanced hepatocellular carcinoma (HCC). However, only a minority of patients benefit from immunotherapy. Therefore, we aimed to identify indicators of therapy …
View article: Strong functional pearl: Harper’s regular-expression matcher in Cedille
Strong functional pearl: Harper’s regular-expression matcher in Cedille Open
This paper describes an implementation of Harper's continuation-based regular-expression matcher as a strong functional program in Cedille; i.e., Cedille statically confirms termination of the program on all inputs. The approach uses neith…
View article: Laryngeal tuberculosis - a rare tuberculosis manifestation as differential diagnosis of a laryngocele
Laryngeal tuberculosis - a rare tuberculosis manifestation as differential diagnosis of a laryngocele Open
A 27-year-old man of Indian descent was introduced with a suspected diagnosis of a branchial cyst. A slowely growing swelling on the paralaryngeal right showed laryngoscopically a protrusion of the right vestibular fold as well as a rednes…
View article: Keratocystoma – facial resection in suspicion of malignancy! Case report of a rare tumor entity with benignancy in the final histological analysis
Keratocystoma – facial resection in suspicion of malignancy! Case report of a rare tumor entity with benignancy in the final histological analysis Open
Tumors of the major salivary glands are usually benign. Among these benignomas the keratocystoma is a rare, largely unknown entity.
View article: Everolimus treatment of a fetal intracardiac rhabdomyoma not associated with the tuberous sclerosis complex: a case report
Everolimus treatment of a fetal intracardiac rhabdomyoma not associated with the tuberous sclerosis complex: a case report Open
Introduction Benign cardiac rhabdomyomas are the most common cardiac tumors in fetuses and children. They are most often located in the ventricles and may disturb myocardial function, the severity correlating with location and size of the …
View article: Variations on Inductive-Recursive Definitions
Variations on Inductive-Recursive Definitions Open
Dybjer and Setzer introduced the definitional principle of inductive-recursively defined families - i.e. of families (U : Set, T : U -> D) such that the inductive definition of U may depend on the recursively defined T --- by defining a ty…
View article: Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl<sup>−</sup> channels
Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl<sup>−</sup> channels Open
Recent studies identified the SLC26A9 Cl − channel as a modifier and potential therapeutic target in cystic fibrosis (CF). However, understanding of the regulation of SLC26A9 in epithelia remains limited and cellular models with stable exp…