Stéphane Berneau
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View article: Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton
Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton Open
Understanding how glucose regulates endometrial function will support preconception guidance and/or the development of targeted interventions for individuals living with diabetes wishing to embark on pregnancy. We found that glucose can in…
View article: Peer Review #2 of "Increased copy number of syncytin-1 in the trophectoderm is associated with implantation of the blastocyst (v0.2)"
Peer Review #2 of "Increased copy number of syncytin-1 in the trophectoderm is associated with implantation of the blastocyst (v0.2)" Open
Background: A key step in embryo implantation is the adhesion to and invasion of the endometrium by the blastocyst trophectoderm.The envelope proteins of HERV-W (human endogenous retrovirus-W), syncytin-1 and syncytin-2, are mainly distrib…
View article: Peer Review #2 of "Increased copy number of syncytin-1 in the trophectoderm is associated with implantation of the blastocyst (v0.1)"
Peer Review #2 of "Increased copy number of syncytin-1 in the trophectoderm is associated with implantation of the blastocyst (v0.1)" Open
Background: A key step in embryo implantation is the adhesion to and invasion of the endometrium by the blastocyst trophectoderm.The envelope proteins of HERV-W (human endogenous retrovirus-W), syncytin-1 and syncytin-2, are mainly distrib…
View article: Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples
Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples Open
Background Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifes…
View article: The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cells in vitro
The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cells in vitro Open
STUDY QUESTION Does embryo transfer medium containing hyaluronate (HA) promote the attachment phase of human embryo implantation? SUMMARY ANSWER HA-containing medium does not promote human blastocyst attachment to endometrial epithelial ce…
View article: Characterisation of Osteopontin in an In Vitro Model of Embryo Implantation
Characterisation of Osteopontin in an In Vitro Model of Embryo Implantation Open
At the onset of pregnancy, embryo implantation is initiated by interactions between the endometrial epithelium and the outer trophectoderm cells of the blastocyst. Osteopontin (OPN) is expressed in the endometrium and is implicated in atta…
View article: Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in vitro model
Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in vitro model Open
Implantation failure is an important impediment to increasing success rates in assisted reproductive technologies. Knowledge of the cascade of morphological and molecular events at implantation remains limited. Cell surface CD44 and hyalur…
View article: Osmotic stress induces JNK-dependent embryo invasion in a model of implantation
Osmotic stress induces JNK-dependent embryo invasion in a model of implantation Open
In vitro culture during assisted reproduction technologies (ART) exposes pre-implantation embryos to environmental stressors, such as non-physiological nutritional, oxidative and osmotic conditions. The effects on subsequent implantation a…
View article: Vitamin D attenuates sphingosine-1-phosphate (S1P)-mediated inhibition of extravillous trophoblast migration
Vitamin D attenuates sphingosine-1-phosphate (S1P)-mediated inhibition of extravillous trophoblast migration Open
This study demonstrates that although EVT express three S1P receptor isoforms, S1P predominantly signals through S1PR2/Gα12/13 to activate Rho and thereby acts as potent inhibitor of EVT migration. Importantly, expression of S1PR2, and the…
View article: Apposition to endometrial epithelial cells activates mouse blastocysts for implantation
Apposition to endometrial epithelial cells activates mouse blastocysts for implantation Open
This work was supported by funds from the charities Wellbeing of Women (RG1442) and Diabetes UK (15/0005207), and studentship support for SCB from the Anatomical Society. No conflict of interest is declared.