Marc Blondel
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View article: New Mechanisms of Resistance to <scp>CAA</scp> and <scp>OSBPI</scp> Fungicides in <i>Phytophthora infestans</i>
New Mechanisms of Resistance to <span>CAA</span> and <span>OSBPI</span> Fungicides in <i>Phytophthora infestans</i> Open
Field observations from Denmark in 2021 suggested a reduction in the efficacy of mandipropamid (MPD), a carboxylic acid amide (CAA) fungicide used against potato late blight ( Phytophthora infestans ). Three P. infestans isolates with repo…
View article: IRF4 haploinsufficiency in a multiplex family with Whipple’s disease
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease Open
Tropheryma whipplei is the bacterial agent responsible for Whipple’s disease (WD). However, WD occurs only very rarely in T. whipplei-infected individuals. We investigated the cause of disease in two relatives with WD. We studied a son and…
View article: The Epstein-Barr virus EBNA1 protein binds to G-quadruplexes in its own mRNA hence controlling its expression and immune evasion of the virus
The Epstein-Barr virus EBNA1 protein binds to G-quadruplexes in its own mRNA hence controlling its expression and immune evasion of the virus Open
The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein (GMP) EBNA1, which is essential for viral genome replication, but also highly antigenic. Hence, the virus evolved a me…
View article: The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in <i>Arabidopsis thaliana</i>
The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in <i>Arabidopsis thaliana</i> Open
Seed dormancy corresponds to a reversible blockage of germination. Primary dormancy is established during seed maturation, while secondary dormancy is set up on the dispersed seed, following an exposure to unfavorable factors. Both dormanc…
View article: The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in<i>Arabidopsis thaliana</i>
The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in<i>Arabidopsis thaliana</i> Open
Seed dormancy corresponds to a reversible blockage of germination. Primary dormancy is established during seed maturation while secondary dormancy is set up on the dispersed seed, following an exposure to unfavourable factors. Both dormanc…
View article: Alternative splicing of <i>BCL-x</i> is controlled by RBM25 binding to a G-quadruplex in <i>BCL-x</i> pre-mRNA
Alternative splicing of <i>BCL-x</i> is controlled by RBM25 binding to a G-quadruplex in <i>BCL-x</i> pre-mRNA Open
BCL-x is a master regulator of apoptosis whose pre-mRNA is alternatively spliced into either a long (canonical) anti-apoptotic Bcl-xL isoform, or a short (alternative) pro-apoptotic Bcl-xS isoform. The balance between these two antagonisti…
View article: Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system
Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system Open
The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1. Indeed, EBNA1 is essential for viral genome maintenance but is also highly antigenic. Hence, EBV seemingly evol…
View article: The nascent polypeptide-associated complex (NAC) controls translation initiation <i>in cis</i> by recruiting nucleolin to the encoding mRNA
The nascent polypeptide-associated complex (NAC) controls translation initiation <i>in cis</i> by recruiting nucleolin to the encoding mRNA Open
Protein aggregates and abnormal proteins are toxic and associated with neurodegenerative diseases. There are several mechanisms to help cells get rid of aggregates but little is known on how cells prevent aggregate-prone proteins from bein…
View article: A homozygous splice variant in <scp><i>ATP5PO</i></scp>, disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families
A homozygous splice variant in <span><i>ATP5PO</i></span>, disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families Open
Mitochondrial complex V plays an important role in oxidative phosphorylation by catalyzing the generation of ATP. Most complex V subunits are nuclear encoded and not yet associated with recognized Mendelian disorders. Using exome sequencin…
View article: The different activities of RNA G-quadruplex structures are controlled by flanking sequences
The different activities of RNA G-quadruplex structures are controlled by flanking sequences Open
The role of G-quadruplex (G4) RNA structures is multifaceted and controversial. Here, we have used as a model the EBV-encoded EBNA1 and the Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded LANA1 mRNAs. We have compared the G4s in the…
View article: An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs
An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs Open
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inheritable cause of end stage renal disease and, as of today, only a single moderately effective treatment is available for patients. Even though ADPKD research has m…
View article: <scp>The importance of naturally attenuated SARS‐CoV</scp> ‐2 <scp>in the fight against COVID</scp> ‐19
<span>The importance of naturally attenuated SARS‐CoV</span> ‐2 <span>in the fight against COVID</span> ‐19 Open
The current SARS‐CoV‐2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID‐19 is why some individuals become sick and others not. Many have pointed already a…
View article: Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice Open
Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main…
View article: Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion
Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion Open
Many pathogens (virus, bacteria, fungi, or parasites) have developed a wide variety of mechanisms to evade their host immune system. The budding yeast Saccharomyces cerevisiae has successfully been used to decipher some of these immune eva…
View article: Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a
Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a Open
Identifying dosage-sensitive genes is a key to understand the mechanisms underlying intellectual disability in Down syndrome (DS). The Dp(17Abcg1-Cbs)1Yah DS mouse model (Dp1Yah) shows cognitive phenotypes that need to be investigated to i…
View article: A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects Open
Mitochondria continually move, fuse and divide and these dynamics are essential for the proper function of these organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their imm…
View article: Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides
Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides Open
Peptides presented on major histocompatibility (MHC) class I molecules form an essential part of the immune system's capacity to detect virus-infected or transformed cells. Earlier works have shown that pioneer translation peptides (PTPs) …
View article: In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules
In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules Open
Protein-RNA interactions (PRIs) control pivotal steps in RNA biogenesis, regulate multiple physiological and pathological cellular networks, and are emerging as important drug targets. However, targeting of specific protein-RNA interaction…
View article: <i>Cbs</i>overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with<i>Dyrk1a</i>
<i>Cbs</i>overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with<i>Dyrk1a</i> Open
Identifying dosage sensitive genes is a key to understand the mechanisms underlying intellectual disability in Down syndrome (DS). The Dp(17Abcg1-Cbs)1Yah DS mouse model (Dp1Yah) show cognitive phenotype and needs to be investigated to ide…
View article: EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers
EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers Open
The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby offers opportunities…