Stéphane Guillouet
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View article: Glycerol-supplemented medium promotes transition of Cupriavidus necator from heterotrophic to lithoautotrophic growth
Glycerol-supplemented medium promotes transition of Cupriavidus necator from heterotrophic to lithoautotrophic growth Open
H2-driven biotransformations in the chemolithoautotrophic bacterium, Cupriavidus necator, are gaining attention to obtain valuable industrial molecules. However, cultivation variability and long lag phases have been reported in …
View article: Aerobic autotrophic isopropanol production under low H2 atmosphere in Hollow Fiber Membrane Bioreactor
Aerobic autotrophic isopropanol production under low H2 atmosphere in Hollow Fiber Membrane Bioreactor Open
View article: Characterization of Single Cell Protein produced by Cupriavidus necator grown on various nitrogen and carbon sources
Characterization of Single Cell Protein produced by Cupriavidus necator grown on various nitrogen and carbon sources Open
Microorganisms can serve as Single Cell Proteins (SCP) used as an alternative and non-conventional protein source to meet the protein shortage and increasing demand. The objective of this research was to characterize growth and biomass com…
View article: Isopropanol production from carbon dioxide by Cupriavidus necator using a zero-gap cell with culture broth as catholyte
Isopropanol production from carbon dioxide by Cupriavidus necator using a zero-gap cell with culture broth as catholyte Open
Microbial CO2 fixation is a promising route for sustainable chemical production. The facultative chemolithoautotroph Cupriavidus necator can convert CO2 into value-added compounds using H2 and O…
View article: Comparative characterisation of autotrophic and heterotrophic isopropanol formation by Cupriavidus necator in shake flasks
Comparative characterisation of autotrophic and heterotrophic isopropanol formation by Cupriavidus necator in shake flasks Open
Autotrophic cultivation offers a path to carbon-neutral bioproduction, which is increasingly valuable in the context of climate change mitigation. In this study, the production of isopropanol by Cupriavidus necator is used as an example fo…
View article: Biodegradation of pre-treated low-density polyethylene (LDPE) by Yarrowia lipolytica determined by oxidation and molecular weight reduction
Biodegradation of pre-treated low-density polyethylene (LDPE) by Yarrowia lipolytica determined by oxidation and molecular weight reduction Open
View article: Identification and monitoring of cell heterogeneity from plasmid recombination during limonene production
Identification and monitoring of cell heterogeneity from plasmid recombination during limonene production Open
Detecting alterations in plasmid structures is often performed using conventional molecular biology. However, these methods are laborious and time-consuming for studying the conditions inducing these mutations, which prevent real-time acce…
View article: Cupriavidus necator as a model organism for CO2-based biotechnology
Cupriavidus necator as a model organism for CO2-based biotechnology Open
View article: Autotrophic and Auto-Inducible Isopropanol Production by Cupriavidus Necator Using Biogas and Incinerator Flue Gases as Carbon Sources
Autotrophic and Auto-Inducible Isopropanol Production by Cupriavidus Necator Using Biogas and Incinerator Flue Gases as Carbon Sources Open
View article: <sup><b>18</b></sup>F-Fluorination of Nitroimidazolyl-Containing Sultone: A Direct Access to a Highly Hydrophilic Radiotracer for High-Performance Positron Emission Tomography Imaging of Hypoxia
<sup><b>18</b></sup>F-Fluorination of Nitroimidazolyl-Containing Sultone: A Direct Access to a Highly Hydrophilic Radiotracer for High-Performance Positron Emission Tomography Imaging of Hypoxia Open
Hypoxia, characterized by nonphysiological levels of oxygen tension, is a key phenomenon common to the majority of malignant tumors with poor prognosis. Many efforts have been made to develop hypoxia imaging for diagnosis, staging, and mon…
View article: Biodegradation of Pre-Treated Low-Density Polyethylene (Ldpe) by Yarrowia Lipolytica Determined by Oxidation and Molecular Weight Reduction
Biodegradation of Pre-Treated Low-Density Polyethylene (Ldpe) by Yarrowia Lipolytica Determined by Oxidation and Molecular Weight Reduction Open
View article: Les protéines issues d’organismes unicellulaires comme nouvelle source de protéines alimentaires : Evaluation de la qualité nutritionnelle chez le rat
Les protéines issues d’organismes unicellulaires comme nouvelle source de protéines alimentaires : Evaluation de la qualité nutritionnelle chez le rat Open
National audience
View article: Autotrophic Production of the Sesquiterpene α-Humulene with Cupriavidus necator in a Controlled Bioreactor
Autotrophic Production of the Sesquiterpene α-Humulene with Cupriavidus necator in a Controlled Bioreactor Open
Cupriavidus necator is a facultative chemolithotrophic organism that grows under both heterotrophic and autotrophic conditions. It is becoming increasingly important due to its ability to convert CO2 into industrially valuable chemicals. T…
View article: Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine
Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine Open
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications. The hydrophilicity of the tetr…
View article: Comparison of plasmid stabilization systems during heterologous isopropanol production in fed-batch bioreactor
Comparison of plasmid stabilization systems during heterologous isopropanol production in fed-batch bioreactor Open
View article: Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine‐18 fluoromisonidazole‐positron emission tomography: A cross‐validation study?
Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine‐18 fluoromisonidazole‐positron emission tomography: A cross‐validation study? Open
Acute ischemic stroke results in an ischemic core surrounded by a tissue at risk, named the penumbra, which is potentially salvageable. One way to differentiate the tissues is to measure the hypoxia status. The purpose of the current study…
View article: First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18F-Fludarabine and l-[methyl-11C]Methionine
First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18F-Fludarabine and l-[methyl-11C]Methionine Open
Objectives This study sought to assess 18 F-fludarabine ( 18 F-FLUDA) PET/CT’s ability in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastoma multiformes (GBMs). Patients and Methods Patients harboring eithe…
View article: Investigation of the robustness of Cupriavidus necator engineered strains during fed-batch cultures
Investigation of the robustness of Cupriavidus necator engineered strains during fed-batch cultures Open
View article: Accelerostat study in conventional and microfluidic bioreactors to assess the key role of residual glucose in the dimorphic transition of Yarrowia lipolytica in response to environmental stimuli
Accelerostat study in conventional and microfluidic bioreactors to assess the key role of residual glucose in the dimorphic transition of Yarrowia lipolytica in response to environmental stimuli Open
View article: Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy
Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy Open
View article: Insights into Clostridium tetani: From genome to bioreactors
Insights into Clostridium tetani: From genome to bioreactors Open
View article: Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, <sup>18</sup>F-FMISO PET, and <sup>18</sup>F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma
Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, <sup>18</sup>F-FMISO PET, and <sup>18</sup>F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma Open
CERVOXY/LDM TEP COLL
View article: Physicochemical composition and fermentation kinetics of a novel Palm Sap-based Kefir Beverage from the fermentation of Borassus aethiopum Mart. fresh sap with kefir grains and ferments
Physicochemical composition and fermentation kinetics of a novel Palm Sap-based Kefir Beverage from the fermentation of Borassus aethiopum Mart. fresh sap with kefir grains and ferments Open
View article: 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study
64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study Open
Background Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu ( 64 Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its u…
View article: Isopropanol production from carbon dioxide in Cupriavidus necator in a pressurized bioreactor
Isopropanol production from carbon dioxide in Cupriavidus necator in a pressurized bioreactor Open
View article: Nutritional, biochemical and microbiological composition of Borassus aethiopum Mart. sap in Burkina Faso
Nutritional, biochemical and microbiological composition of Borassus aethiopum Mart. sap in Burkina Faso Open
View article: Alka(e)ne synthesis in <i>Cupriavidus necator</i> boosted by the expression of endogenous and heterologous ferredoxin–ferredoxin reductase systems
Alka(e)ne synthesis in <i>Cupriavidus necator</i> boosted by the expression of endogenous and heterologous ferredoxin–ferredoxin reductase systems Open
To boost aldehyde deformylating oxygenase (ADO) activity in a Cupriavidus necator strain expressing a synthetic alkane pathway, the expression of two ferredoxin–ferredoxin reductase systems was tested. The genes of a native fd/FNR‐like sys…
View article: <sup>18</sup>F-Fludarabine PET for Lymphoma Imaging: First-in-Humans Study on DLBCL and CLL Patients
<sup>18</sup>F-Fludarabine PET for Lymphoma Imaging: First-in-Humans Study on DLBCL and CLL Patients Open
This was the first-in-humans clinical study of 18F-fludarabine, which is a radiopharmaceutical for PET imaging in lymphoma, for which many issues remain controversial with the standard radiotracer 18F-FDG. Methods:…
View article: [<sup>18</sup>F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [<sup>18</sup>F]FDG in human xenograft models
[<sup>18</sup>F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [<sup>18</sup>F]FDG in human xenograft models Open
This paper investigated whether positron emission tomography (PET) imaging with [18F]fludarabine ([18F]FDB) can help to differentiate central nervous system lymphoma (CNSL) from glioblastoma (GBM), which is a crucial issue in the diagnosis…
View article: Modeling and optimization of lipid accumulation by <i>Yarrowia lipolytica</i> from glucose under nitrogen depletion conditions
Modeling and optimization of lipid accumulation by <i>Yarrowia lipolytica</i> from glucose under nitrogen depletion conditions Open
Oleaginous yeasts have been seen as a feasible alternative to produce the precursors of biodiesel due to their capacity to accumulate lipids as triacylglycerol having profiles with high content of unsaturated fatty acids. The yeast Yarrowi…