Stéphane Hausmann
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View article: Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa
Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa Open
The RNA degradosome is a bacterial multi-protein complex mediating mRNA processing and degradation. In Pseudomonadota, this complex assembles on the C-terminal domain (CTD) of RNase E through short linear motifs (SLiMs) that determine its …
View article: Critical functions and key interactions mediated by the RNase E scaffolding domain in<i>Pseudomonas aeruginosa</i>
Critical functions and key interactions mediated by the RNase E scaffolding domain in<i>Pseudomonas aeruginosa</i> Open
The RNA degradosome is a bacterial multi-protein complex mediating mRNA processing and degradation. In Pseudomonadota, this complex assembles on the C-terminal domain (CTD) of RNase E through short linear motifs (SLiMs) that determine its …
View article: Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria Open
RNA helicases—central enzymes in RNA metabolism—often feature intrinsically disordered regions (IDRs) that enable phase separation and complex molecular interactions. In the bacterial pathogen Pseudomonas aeruginosa, the non-redundant RhlE…
View article: Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria Open
RNA helicases—central enzymes in RNA metabolism— often feature intrinsically disordered regions (IDRs) that enable phase separation and complex molecular interactions. In the bacterial pathogen Pseudomonas aeruginosa , the non-redundant Rh…
View article: Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students
Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students Open
Background Because of COVID-19, the 2020 written medical examinations were replaced by mandatory formative online assessments. This study aimed to determine students’ performance, self-assessment of performance, and perception about the sw…
View article: Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students
Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students Open
Background: Because of COVID-19, the 2020 written medical examinations were replaced by mandatory formative online assessments. This study aimed to determine students’ performance, self-assessment of performance, and perception about the s…
View article: Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students
Formative assessments during COVID-19 pandemic: an observational study on performance and experiences of medical students Open
Background: Because of COVID-19, the 2020 written medical examinations were replaced by mandatory formative online assessments. This study aimed to determine students’ performance, self-assessment of performance, and perception about the s…
View article: Mechanism of inhibition of bacterial RNA helicases by diazo dyes and implications for antimicrobial drug development
Mechanism of inhibition of bacterial RNA helicases by diazo dyes and implications for antimicrobial drug development Open
RNA helicases represent attractive drug targets as their activity is linked to several human diseases and impacts microbial infectious processes. While some inhibitors of human RNA helicases demonstrated therapeutic potential as anticancer…
View article: The DEAD-box RNA helicase RhlE2 is a global regulator of <i>Pseudomonas aeruginosa</i> lifestyle and pathogenesis
The DEAD-box RNA helicase RhlE2 is a global regulator of <i>Pseudomonas aeruginosa</i> lifestyle and pathogenesis Open
RNA helicases perform essential housekeeping and regulatory functions in all domains of life by binding and unwinding RNA molecules. The bacterial RhlE-like DEAD-box RNA helicases are among the least well studied of these enzymes. They are…
View article: RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication
RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication Open
Plasmids need to ensure their transmission to both daughter-cells when their host divides, but should at the same time avoid overtaxing their hosts by directing excessive host-resources toward production of plasmid factors. Naturally occur…
View article: The DEAD-box RNA helicases RhlE2 is a global regulator of<i>Pseudomonas aeruginosa</i>lifestyle and pathogenesis
The DEAD-box RNA helicases RhlE2 is a global regulator of<i>Pseudomonas aeruginosa</i>lifestyle and pathogenesis Open
The RhlE DEAD-box RNA helicase protein family is widespread among Proteobacteria, but it is the least understood due to the lack of a clear biological function. Here, we study the two RhlE homologs present in the opportunistic pathogen Pse…
View article: Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences
Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences Open
RNA helicases are fundamental players in RNA metabolism: they remodel RNA secondary structures and arrange ribonucleoprotein complexes. While DExH-box RNA helicases function in ribosome biogenesis and splicing in eukaryotes, information is…
View article: Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences
Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences Open
RNA helicases are fundamental players in RNA metabolism: they remodel RNA secondary structures and arrange ribonucleoprotein complexes. While DExH-box RNA helicases function in ribosome biogenesis and splicing in eukaryotes, information is…
View article: Both exo- and endo-nucleolytic activities of RNase J1 from <i>Staphylococcus aureus</i> are manganese dependent and active on triphosphorylated 5′-ends
Both exo- and endo-nucleolytic activities of RNase J1 from <i>Staphylococcus aureus</i> are manganese dependent and active on triphosphorylated 5′-ends Open
RNA decay and RNA maturation are important steps in the regulation of bacterial gene expression. RNase J, which is present in about half of bacterial species, has been shown to possess both endo- and 5' to 3' exo-ribonuclease activities. T…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen<i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen<i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: Bacterial versatility requires DEAD-box RNA helicases
Bacterial versatility requires DEAD-box RNA helicases Open
RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. …
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…