Stéphane Pelleau
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View article: Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR prospective, multicenter cohort study
Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR prospective, multicenter cohort study Open
Background Despite advances in treatment, critically ill COVID-19 patients requiring intensive care unit (ICU) admission continue to comprise a substantial proportion of cases. However, the factors influencing poor prognosis in this popula…
View article: Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations
Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations Open
These findings highlight the potential of high-throughput multiplex serology assays for routine surveillance of common viral infections and assessment of vaccine coverage.
View article: Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance
Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance Open
Background Serological assays are key tools in infectious disease surveillance, enabling detection of past infections by measuring antibody responses. Determining appropriate seropositivity cutoffs, thresholds distinguishing between positi…
View article: Assessment of Plasmodium vivax transmission and asymptomatic carriage risk among artisanal gold miners in western French Guiana, 2014–2020
Assessment of Plasmodium vivax transmission and asymptomatic carriage risk among artisanal gold miners in western French Guiana, 2014–2020 Open
View article: Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort
Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort Open
Numerous studies elucidated the kinetics of the humoral immune response post-SARS-CoV-2 infection. However, in sub-Saharan Africa, the evolution of SARS-CoV-2 IgG antibody responses and their interaction with pre-existing seasonal human co…
View article: Temporal Patterns of Haplotypic and Allelic Diversity Reflect the Changing Selection Landscape of the Malaria Parasite <i>Plasmodium falciparum</i>
Temporal Patterns of Haplotypic and Allelic Diversity Reflect the Changing Selection Landscape of the Malaria Parasite <i>Plasmodium falciparum</i> Open
The malaria parasite Plasmodium falciparum regularly confronts orchestrated changes in frontline drug treatment that drastically alter its selection landscape. When this has occurred, the parasite has successfully adapted to new drugs thro…
View article: Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case–Control Study
Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case–Control Study Open
Background Establishing correlates of protection often requires large cohorts. A rapid and adaptable case–control study design can be used to identify antibody correlates of protection against severe acute respiratory syndrome coronavirus …
View article: Multiplex ACE2-RBD Binding Inhibition Assay: An Integrated Tool for Assessing Neutralizing Antibodies to SARS-CoV-2 Variants and Protection against Breakthrough Infections
Multiplex ACE2-RBD Binding Inhibition Assay: An Integrated Tool for Assessing Neutralizing Antibodies to SARS-CoV-2 Variants and Protection against Breakthrough Infections Open
SARS-CoV-2 remains a significant health threat due to its high infection and mutation rates. The emergence of new variants of concern poses challenges as they can lead to immune escape mutations, potentially reducing the efficacy of vaccin…
View article: Which diagnostic test to use for Testing and Treatment strategies in Plasmodium vivax low-transmission settings: a secondary analysis of a longitudinal interventional study
Which diagnostic test to use for Testing and Treatment strategies in Plasmodium vivax low-transmission settings: a secondary analysis of a longitudinal interventional study Open
Supported by European Funds for Regional Development, French Guiana Regional Health Agency, Pan American Health Organization, WHO, French Ministry for Research.
View article: CUREMA project: a further step towards malaria elimination among hard-to-reach and mobile populations
CUREMA project: a further step towards malaria elimination among hard-to-reach and mobile populations Open
View article: Temporal patterns of haplotypic and allelic diversity reflect the changing selection landscape of the malaria parasite<i>Plasmodium falciparum</i>
Temporal patterns of haplotypic and allelic diversity reflect the changing selection landscape of the malaria parasite<i>Plasmodium falciparum</i> Open
Populations of the malaria parasite Plasmodium falciparum regularly confront orchestrated changes in frontline drug treatment that drastically alter the parasite’s selection landscape. When this has occurred, the parasite has successfully …
View article: Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations using a multiplex serological assay
Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations using a multiplex serological assay Open
Vaccine-preventable diseases (VPDs) and common viral infections (CVIs) pose substantial public health challenges. Despite data collected through routine vaccination programs and through hospital-based case reporting systems, the understand…
View article: CUREMA project: a further step towards malaria elimination among hard-to-reach and mobile populations
CUREMA project: a further step towards malaria elimination among hard-to-reach and mobile populations Open
Background: In most countries engaged on the last mile towards malaria elimination, residual transmission mainly persists among vulnerable populations represented by isolated and mobile (often cross-border) communities. These populations a…
View article: Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in The Guianas: a descriptive epidemiological study
Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in The Guianas: a descriptive epidemiological study Open
View article: Molecular detection of human Plasmodium species using a multiplex real time PCR
Molecular detection of human Plasmodium species using a multiplex real time PCR Open
Molecular detection methods have revealed higher sensitivity and specificity than conventional microscopy or rapid diagnostic tests for malaria diagnosis. In this study, we implemented, evaluated and validated according to the ISO 15,189 r…
View article: Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France
Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France Open
Background The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed. Methods In a cross-sectional study, 2389 serum samples were collected from children…
View article: Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021
Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021 Open
Background The risk of SARS-CoV-2 (re-)infection remains present given waning of vaccine-induced and infection-acquired immunity, and ongoing circulation of new variants. Aim To develop a method that predicts virus neutralisation and disea…
View article: Neutralising antibody responses to SARS-CoV-2 omicron among elderly nursing home residents following a booster dose of BNT162b2 vaccine: A community-based, prospective, longitudinal cohort study
Neutralising antibody responses to SARS-CoV-2 omicron among elderly nursing home residents following a booster dose of BNT162b2 vaccine: A community-based, prospective, longitudinal cohort study Open
View article: Declines in prevalence alter the optimal level of sexual investment for the malaria parasite <i>Plasmodium falciparum</i>
Declines in prevalence alter the optimal level of sexual investment for the malaria parasite <i>Plasmodium falciparum</i> Open
Successful infectious disease interventions can result in large reductions in parasite prevalence. Such demographic change has fitness implications for individual parasites and may shift the parasite’s optimal life history strategy. Here, …
View article: Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination
Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination Open
Serological assays capable of measuring antibody responses induced by previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been critical tools in the response to the COVID-19 pandemic. In this study, we…
View article: Humoral Immunity to SARS-CoV-2 and Inferred Protection from Infection in a French Longitudinal Community Cohort
Humoral Immunity to SARS-CoV-2 and Inferred Protection from Infection in a French Longitudinal Community Cohort Open
Population-level immunity to SARS-CoV-2 is growing through vaccination as well as ongoing circulation. Given waning immunity and emergence of new variants, it is important to dynamically determine the risk of re-infection in the population…
View article: SARS-CoV-2 Omicron neutralization and risk of infection among elderly after a booster dose of Pfizer vaccine
SARS-CoV-2 Omicron neutralization and risk of infection among elderly after a booster dose of Pfizer vaccine Open
Background The protective immunity against Omicron following a BNT162b2 Pfizer booster dose among elderly is not well characterized. Methods Thirty-eight residents from three nursing homes were recruited for the study. Antibodies targeting…
View article: Correction to: Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection
Correction to: Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection Open
View article: Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection
Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection Open
View article: Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France
Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France Open
This work was supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur, by the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (Grant N…
View article: Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection
Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection Open
Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time. Methods We developed a multiplex serological t…
View article: Field Performance of Mass PCR Screening and Targeted Treatment in an Amazonian Low Malaria Transmission Setting
Field Performance of Mass PCR Screening and Targeted Treatment in an Amazonian Low Malaria Transmission Setting Open
The three main obstacles to the elimination of malaria in French Guiana are asymptomatic carriers of Plasmodium vivax , relapses and, to a lesser extent, Plasmodium falciparum . This study aims to assess the impact of PCR-based mass screen…
View article: Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats
Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats Open
View article: Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies
Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies Open
View article: Serological reconstruction of COVID-19 epidemics through analysis of antibody kinetics to SARS-CoV-2 proteins
Serological reconstruction of COVID-19 epidemics through analysis of antibody kinetics to SARS-CoV-2 proteins Open
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time. Waning antibody levels lead to reduced sensitivity of ser…