Stéphane Ransac
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View article: The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes?
The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes? Open
View article: A Theoretical Model of Mitochondrial ATP Synthase Deficiencies. The Role of Mitochondrial Carriers
A Theoretical Model of Mitochondrial ATP Synthase Deficiencies. The Role of Mitochondrial Carriers Open
The m.8993T>G mutation of the mitochondrial MT-ATP6 gene is associated with NARP syndrome (neuropathy, ataxia and retinitis pigmentosa). The equivalent point mutation introduced in yeast Saccharomyces cerevisiae mitochondrial DNA considera…
View article: A theoretical model of mitochondrial ATP synthase deficiencies. The role of mitochondrial carriers
A theoretical model of mitochondrial ATP synthase deficiencies. The role of mitochondrial carriers Open
The m.8993T > G mutation of the mitochondrial MT-ATP6 gene is associated with NARP syndrome (Neuropathy, Ataxia and Retinitis Pigmentosa). The equivalent point mutation introduced in yeast Saccharomyces cerevisiae mitochondrial DNA conside…
View article: The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation
The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation Open
O. Warburg conducted one of the first studies on tumor energy metabolism. His early discoveries pointed out that cancer cells display a decreased respiration and an increased glycolysis proportional to the increase in their growth rate, su…
View article: Cell energy metabolism: An update
Cell energy metabolism: An update Open
View article: Ascorbate maintains a low plasma oxygen level
Ascorbate maintains a low plasma oxygen level Open
View article: Ascorbate maintains a low plasma low oxygen level
Ascorbate maintains a low plasma low oxygen level Open
In human blood, oxygen is mainly transported by red blood cells. Accordingly, the oxygen level in plasma is expected to be limited, although it has not been quantified yet. Here, by developing dedicated methods and tools, we determined tha…
View article: Neutrophil Metabolic Shift during Their Lifecycle: Impact on Their Survival and Activation
Neutrophil Metabolic Shift during Their Lifecycle: Impact on Their Survival and Activation Open
Polymorphonuclear neutrophils (PMNs) are innate immune cells, which represent 50% to 70% of the total circulating leukocytes. How PMNs adapt to various microenvironments encountered during their life cycle, from the bone marrow, to the blo…
View article: Modelling mitochondrial ROS production by the respiratory chain
Modelling mitochondrial ROS production by the respiratory chain Open
View article: The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells
The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells Open
Genome-scale models of metabolism (GEM) are used to study how metabolism varies in different physiological conditions. However, the great number of reactions involved in GEM makes it difficult to understand these variations. In order to ha…
View article: The stochastic modeling of proton pumping in cytochrome <i>c</i> oxidase: the contribution of the K-channel
The stochastic modeling of proton pumping in cytochrome <i>c</i> oxidase: the contribution of the K-channel Open
The influence of pH on the activity of cytochrome c oxidase is investigated using the stochastic modelling based on Markov processes. The functioning of the K-channel is considered on four different schemes. A change of channel modes can b…
View article: The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect
The role of glycolysis-derived hexose phosphates in the induction of the Crabtree effect Open