Stéphane Vignot
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View article: Towards a better understanding of patient expectations: ONCOPREMs-1 study—a qualitative study
Towards a better understanding of patient expectations: ONCOPREMs-1 study—a qualitative study Open
The results of this study show that the different stages of the care pathway generally meet the expectations and needs of patients treated for cancer. However, patients expressed hopes for further developments, such as more support and gui…
View article: Enhanced expression of galectin‐9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy
Enhanced expression of galectin‐9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy Open
Optimizations are expected in the development of immunotherapy for the treatment of Triple‐negative breast cancer (TNBC). We studied the expression of galectin‐9 (Gal‐9) after irradiation and assessed the differential impacts of its target…
View article: Prevention and management of health products shortages by the French national agency (ANSM), 10 years of experience
Prevention and management of health products shortages by the French national agency (ANSM), 10 years of experience Open
Shortages of drugs and medical devices have tended to increase in France and worldwide, with consequences for patients and healthcare professionals. Preventing shortages of health products has become a priority for regulatory authorities, …
View article: Clinical Trial Authorisation: A Final Look Back to Better Appraise theNew European Regulation
Clinical Trial Authorisation: A Final Look Back to Better Appraise theNew European Regulation Open
The implementation of the new European Clinical Trial Regulation on 31 January 2022, is a major step to promote clinical research in Europe. The French National Agency for Medicines and Health Products Safety (ANSM) proposes to share some …
View article: Authorization of COVID-19 clinical trials: lessons from 2 years of experience of a national competent authority
Authorization of COVID-19 clinical trials: lessons from 2 years of experience of a national competent authority Open
The COVID-19 pandemic was immediately marked by strong clinical research activity. The French national competent authority presents the data on request for authorization during the first 2 years of COVID-19 pandemic to inform discussions o…
View article: Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer
Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer Open
Our study confirmed the high degree of concordance between MSI and MMR IHC tests. Discordant cases must be reviewed, and if needed, tests must be repeated and analyzed by an expert team.
View article: Facilitating access to new therapeutic options through clinical trials: the vision of a regulator to reconcile innovation and safety
Facilitating access to new therapeutic options through clinical trials: the vision of a regulator to reconcile innovation and safety Open
In the field of onco-hematology, targeted molecular therapies, immunotherapies and personalized treatments are undoubtedly a source of hope not only for patients and their relatives, but also for caregivers, in whom this hope is also combi…
View article: A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal
A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal Open
A key constraint in genomic testing in oncology is that matched normal specimens are not commonly obtained in clinical practice. Thus, while well-characterized genomic alterations do not require normal tissue for interpretation, a signific…
View article: Should Adjuvant Radiation Therapy Be Systematically Proposed for Male Breast Cancer? A Systematic Review
Should Adjuvant Radiation Therapy Be Systematically Proposed for Male Breast Cancer? A Systematic Review Open
MBC is diagnosed at a highly advanced stage and may be linked with poorer outcomes. Adjuvant radiation therapy must, at least, be proposed to men with positive nodes. Despite the large number of cases gathered here, arguments for radiother…
View article: Mechanisms of phosphenes in irradiated patients
Mechanisms of phosphenes in irradiated patients Open
Anomalous visual perceptions have been reported in various diseases of the retina and visual pathways or can be experienced under specific conditions in healthy individuals. Phosphenes are perceptions of light in the absence of ambient lig…