Stephanie A. Corio
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View article: Direct α-C–H Heteroarylation of Unprotected Primary Amines
Direct α-C–H Heteroarylation of Unprotected Primary Amines Open
The innate reactivity of unprotected primary alkylamines is dominated by electrophilic N-functionalization, and only recently have catalytic strategies begun to access direct C–C bond formation at the α-position. Nucleophilic aromatic subs…
View article: Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization
Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization Open
We report a dynamic kinetic asymmetric transformation (DyKAT) of racemic aldehydes by Rh-catalyzed hydroacylation of acrylamides. This intermolecular hydroacylation generates 1,4-ketoamides with high enantio- and diastereoselectivity. DFT …
View article: Copper Catalysis with Arynes: Unlocking Site-Selective Arylation of Pyrazoles
Copper Catalysis with Arynes: Unlocking Site-Selective Arylation of Pyrazoles Open
Arynes are among the most reactive species in organic chemistry—six-membered rings so strained that their energy rivals that of a hand grenade.1 Since their discovery in 1902, chemists have used arynes to achieve innovative tran…
View article: A Lewis Acid-Controlled Enantiodivergent Epoxidation of Aldehydes
A Lewis Acid-Controlled Enantiodivergent Epoxidation of Aldehydes Open
Two epoxidation catalysts, one of which consists of two VANOL ligands and an aluminum and the other that consists of two VANOL ligands and a boron, were compared. Both catalysts are highly effective in the catalytic asymmetric epoxidation …
View article: CCDC 1972358: Experimental Crystal Structure Determination
CCDC 1972358: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2154097: Experimental Crystal Structure Determination
CCDC 2154097: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2100976: Experimental Crystal Structure Determination
CCDC 2100976: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes
Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes Open
Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo-, and enantiocontrol. The observed N2:N<…
View article: Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes**
Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes** Open
We describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: A Lewis Acid-Controlled Enantiodivergent Epoxidation
A Lewis Acid-Controlled Enantiodivergent Epoxidation Open
Two epoxidation catalysts one of which consists of two VANOL ligands and an aluminum and the other of two VANOL ligands and a boron were compared. Both catalysts are highly effective in the catalytic asymmetric epoxidation of a variety of …
View article: Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes
Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes Open
We describe a copper-catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: Copper-Phosphido Catalysis: Enantioselective Coupling of Phosphines and Cyclopropenes
Copper-Phosphido Catalysis: Enantioselective Coupling of Phosphines and Cyclopropenes Open
We describe a copper-catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes
Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes Open
Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions─hydroesterification, hydroamination, and hydroetherific…
View article: Probing the Free Energy Landscape of Organophotoredox Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes
Probing the Free Energy Landscape of Organophotoredox Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes Open
Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions – hydroesterification, hydroamination, and hydroetherification – e…