Stephanie A. Matthews
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View article: In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment
In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment Open
Background/Objectives: Hyperexcitable neuronal activity associated with seizures may disrupt brain homeostasis resulting in abnormal glucose and nutrient management and metabolism. Specialized ependymal cells known as tanycytes line the th…
View article: Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons
Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons Open
Failure to recover from repeated hypercapnia and hypoxemia (HH) challenges caused by severe GCS and postictal apneas may contribute to sudden unexpected death in epilepsy (SUDEP). Our previous studies found orexinergic dysfunction contribu…
View article: Multiple asymptomatic, hyperkeratotic minute filiform papules
Multiple asymptomatic, hyperkeratotic minute filiform papules Open
View article: Vitiligo overlying varicose veins: Three cases of a rare possible Koebner phenomenon
Vitiligo overlying varicose veins: Three cases of a rare possible Koebner phenomenon Open
View article: Personalization of SUDEP risk: A survey of transient subclinical comorbid changes
Personalization of SUDEP risk: A survey of transient subclinical comorbid changes Open
View article: Preoperative Marking to Approximate Forehead Rhytids for Precisely Camouflaging Scars
Preoperative Marking to Approximate Forehead Rhytids for Precisely Camouflaging Scars Open
View article: Acral Nodular Melanoma at a Site of Trauma
Acral Nodular Melanoma at a Site of Trauma Open
View article: Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices
Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices Open
View article: JAAD Case Reports article list
JAAD Case Reports article list Open
View article: Characterizing Outcomes of Medial and Lateral Perforators in Deep Inferior Epigastric Perforator Flaps
Characterizing Outcomes of Medial and Lateral Perforators in Deep Inferior Epigastric Perforator Flaps Open
Background Perforators are typically found in rows in the deep inferior epigastric perforator (DIEP) flap. As methods to assess flap perfusion continue to improve, surgeons may be more likely to select perforators traditionally avoided. Th…
View article: Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices
Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices Open
Ascorbic acid (AA; a.k.a. vitamin C) is well known for its cellular protection in environments of high oxidative stress. Even though physiological concentrations of AA in the brain are significant (0.2–10 mM), surprisingly little is known …
View article: Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice
Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice Open
View article: Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices
Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices Open
Higher therapeutic concentrations of the antiseizure medication carbamazepine (CBZ) are associated with cognitive side effects. Hippocampal sharp wave-ripple complexes (SPW-Rs) are proposed to participate in memory consolidation during per…
View article: Respiratory dysfunction progresses with age in <i>Kcna1</i>‐null mice, a model of sudden unexpected death in epilepsy
Respiratory dysfunction progresses with age in <i>Kcna1</i>‐null mice, a model of sudden unexpected death in epilepsy Open
Summary Objective Increased breathing rate, apnea, and respiratory failure are associated with sudden unexpected death in epilepsy ( SUDEP ). We recently demonstrated the progressive nature of epilepsy and mortality in Kcna1 −/− mice, a mo…
View article: Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy
Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy Open
Summary Objective Chronic sleep deficiency is associated with early mortality. In the epileptic population, there is a higher prevalence of sleep disorders, and individuals with severe refractory epilepsy are at greater risk of premature m…
View article: Synergistic protection against acute flurothyl‐induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone
Synergistic protection against acute flurothyl‐induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone Open
Summary Objective We have previously found that the transcription factor peroxisome proliferator‐activated receptor γ ( PPAR γ) contributes to the mechanism of action of the ketogenic diet ( KD ), an established treatment for pediatric ref…
View article: Ketogenic diet treatment increases longevity in <i>Kcna1</i>‐null mice, a model of sudden unexpected death in epilepsy
Ketogenic diet treatment increases longevity in <i>Kcna1</i>‐null mice, a model of sudden unexpected death in epilepsy Open
Summary Individuals with poorly controlled epilepsy have a higher risk for sudden unexpected death in epilepsy ( SUDEP ). With approximately one third of people with epilepsy not achieving adequate seizure control with current antiseizure …
View article: Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in<i>Kcna1</i>-null Mice
Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in<i>Kcna1</i>-null Mice Open
Comorbid sleep disorders occur in approximately one-third of people with epilepsy. Seizures and sleep disorders have an interdependent relationship where the occurrence of one can exacerbate the other. Orexin, a wake-promoting neuropeptide…