Stephanie A. Terezakis
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View article: RBIO-19. Radiation-Mediated MDSC Immunodynamics in Recurrent High-Grade Glioma
RBIO-19. Radiation-Mediated MDSC Immunodynamics in Recurrent High-Grade Glioma Open
Myeloid-derived suppressor cells (MDSCs) contribute to an immunosuppressive tumor microenvironment that facilitates cancer progression, particularly in patients with high-grade gliomas. We previously reported that increased MDSCs during ch…
View article: Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma Consortium
Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma Consortium Open
Cancer Research Foundation, Children's Research Foundation, Comer Development Board, KickCancer, King Baudouin Foundation, Rally Foundation for Childhood Cancer Research, Seattle Children's Foundation from Kat's Crew Guild through the Scle…
View article: Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study
Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study Open
Despite the increasing utilization of bridging radiotherapy (Br-RT), its impact on chimeric antigen receptor T-cell therapy (CAR-T) efficacy and toxicity remains poorly characterized. We retrospectively reviewed patients with relapsed/refr…
View article: The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation
The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation Open
View article: Effect of External Beam Radiation Therapy and Brachytherapy on Circulating Myeloid-Derived Suppressor Cell Populations in Patients Treated Definitively for Cervical Cancer
Effect of External Beam Radiation Therapy and Brachytherapy on Circulating Myeloid-Derived Suppressor Cell Populations in Patients Treated Definitively for Cervical Cancer Open
Our study confirms other reports that circulating MDSCs in patients with cervical cancer increase in response to CRT and are associated with more advanced stages. Additionally, we show that MDSC expansion is driven by the g-MDSC subset. We…
View article: Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial
Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial Open
This report elaborates on the methodology and timeline of trial conception and development using data from a previously published supportive care study combining video immersion with radiation therapy among 10 cooperating pediatric oncolog…
View article: Role of HIF-1α in the Responses of Tumors to Radiotherapy and Chemotherapy
Role of HIF-1α in the Responses of Tumors to Radiotherapy and Chemotherapy Open
Tumor microenvironment is intrinsically hypoxic with abundant hypoxia-inducible factors-1α (HIF-1α), a primary regulator of the cellular response to hypoxia and various stresses imposed on the tumor cells. HIF-1α increases radioresistance …
View article: Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership
Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership Open
View article: Comparison of peripheral leukocyte parameters in patients receiving conventionally and hypofractionated radiotherapy schemes for the treatment of newly diagnosed glioblastoma
Comparison of peripheral leukocyte parameters in patients receiving conventionally and hypofractionated radiotherapy schemes for the treatment of newly diagnosed glioblastoma Open
Introduction Treatment for glioblastomas, aggressive and nearly uniformly fatal brain tumors, provide limited long-term success. Immunosuppression by myeloid cells in both the tumor microenvironment and systemic circulation are believed to…
View article: Preferential Tumor Vascular Damage Is the Common Antitumor Mechanism of High-Dose Hypofractionated Radiation Therapy: SABR, Spatially Fractionated Radiation Therapy, and FLASH Radiation Therapy
Preferential Tumor Vascular Damage Is the Common Antitumor Mechanism of High-Dose Hypofractionated Radiation Therapy: SABR, Spatially Fractionated Radiation Therapy, and FLASH Radiation Therapy Open
Remarkable technological advances in recent years led to the development of new radiation therapy methods, such as SABR, SFRT (spatially fractionated radiation therapy), and FLASH-RT (FLASH radiation therapy). The common features of these …
View article: Feasibility of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) System for Anesthesia Avoidance in Pediatric Patients: A Multicenter Trial
Feasibility of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) System for Anesthesia Avoidance in Pediatric Patients: A Multicenter Trial Open
View article: Efficacy and Safety of Stereotactic Body Radiation Therapy for Pediatric Malignancies: The LITE-SABR Systematic Review and Meta-Analysis
Efficacy and Safety of Stereotactic Body Radiation Therapy for Pediatric Malignancies: The LITE-SABR Systematic Review and Meta-Analysis Open
View article: “Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community
“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community Open
Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimen…
View article: The Evolving Role of Radiotherapy for Pediatric Cancers With Advancements in Molecular Tumor Characterization and Targeted Therapies
The Evolving Role of Radiotherapy for Pediatric Cancers With Advancements in Molecular Tumor Characterization and Targeted Therapies Open
Ongoing rapid advances in molecular diagnostics, precision imaging, and development of targeted therapies have resulted in a constantly evolving landscape for treatment of pediatric cancers. Radiotherapy remains a critical element of the t…
View article: Radiation Therapy Across Pediatric Hodgkin Lymphoma Research Group Protocols: A Report From the Staging, Evaluation, and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) Group
Radiation Therapy Across Pediatric Hodgkin Lymphoma Research Group Protocols: A Report From the Staging, Evaluation, and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) Group Open
View article: Predictors of Recurrence and Patterns of Initial Failure in Localized Ewing Sarcoma: A Contemporary 20-Year Experience
Predictors of Recurrence and Patterns of Initial Failure in Localized Ewing Sarcoma: A Contemporary 20-Year Experience Open
Background. The majority of patients with localized Ewing sarcoma will remain disease-free long term, but for those who suffer recurrence, successful treatment remains a challenge. Identification of clinicopathologic factors predictive of …
View article: EPEN-50. THE MANAGEMENT AND TREATMENT OF PEDIATRIC SPINAL CORD EPENDYMOMA: RESULTS FROM A COLLABORATIVE INTERNATIONAL MULTI-INSTITUTIONAL REVIEW
EPEN-50. THE MANAGEMENT AND TREATMENT OF PEDIATRIC SPINAL CORD EPENDYMOMA: RESULTS FROM A COLLABORATIVE INTERNATIONAL MULTI-INSTITUTIONAL REVIEW Open
PURPOSE Pediatric Spinal cord ependymoma (SCE) is rare, and the management is often heterogeneous across centers. We evaluated the impact of clinical, pathologic, and treatment-related factors on outcomes in a multi-institutional, internat…
View article: A multi‐institutional phase 2 trial of stereotactic body radiotherapy in the treatment of bone metastases in pediatric and young adult patients with sarcoma
A multi‐institutional phase 2 trial of stereotactic body radiotherapy in the treatment of bone metastases in pediatric and young adult patients with sarcoma Open
Background Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the autho…
View article: Pediatric Radiation Oncology Practice Patterns according to Children’s Oncology Group Protocol Treatment.
Pediatric Radiation Oncology Practice Patterns according to Children’s Oncology Group Protocol Treatment. Open
View article: Management and Treatment of Pediatric Spinal Cord Ependymoma: Results from an International Multi-Institutional Review
Management and Treatment of Pediatric Spinal Cord Ependymoma: Results from an International Multi-Institutional Review Open
View article: Race Disparities in High-cost, Limited Resource Cancer Treatment: Proton Radiotherapy Use in Patients Enrolled on Children’s Oncology Group Trials
Race Disparities in High-cost, Limited Resource Cancer Treatment: Proton Radiotherapy Use in Patients Enrolled on Children’s Oncology Group Trials Open
View article: Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development
Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development Open
A large number of publications recommended hypofractionated radiation therapy schedules across numerous major disease sites during the COVID-19 pandemic, which were supported by a lower quality of evidence than the highest-quality routinel…
View article: Indirect cell death and the LQ model in SBRT and SRS.
Indirect cell death and the LQ model in SBRT and SRS. Open
High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell deat…
View article: Neoadjuvant Chemoradiation Compared With Neoadjuvant Radiation Alone in the Management of High-Grade Soft Tissue Extremity Sarcomas
Neoadjuvant Chemoradiation Compared With Neoadjuvant Radiation Alone in the Management of High-Grade Soft Tissue Extremity Sarcomas Open
View article: A Multi-Institutional Prospective Phase II Trial of Hypofractionated Stereotactic Body Radiotherapy (SBRT) in the Treatment of Metastatic Pediatric Sarcomas of Bone Sites
A Multi-Institutional Prospective Phase II Trial of Hypofractionated Stereotactic Body Radiotherapy (SBRT) in the Treatment of Metastatic Pediatric Sarcomas of Bone Sites Open
View article: Palliative radiation oncology in pediatric patients
Palliative radiation oncology in pediatric patients Open
Radiation therapy (RT) provides an effective and often rapid means to alleviate symptomatic progression in pediatric patients with advanced or metastatic cancer. As part of a comprehensive, multimodality approach to pediatric palliative ca…
View article: STAGE I‐II NODULAR LYMPHOCYTE‐PREDOMINANT HODGKIN LYMPHOMA IN THE MODERN ERA: A MULTI‐INSTITUTIONAL EXPERIENCE OF ADULT PATIENTS BY ILROG
STAGE I‐II NODULAR LYMPHOCYTE‐PREDOMINANT HODGKIN LYMPHOMA IN THE MODERN ERA: A MULTI‐INSTITUTIONAL EXPERIENCE OF ADULT PATIENTS BY ILROG Open
Introduction: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of HL; the optimal management of stage I-II remains undefined. Methods: We conducted a multi-center retrospective study including patients (pts) ≥…
View article: Adoption of an incident learning system in a regionally expanding academic radiation oncology department
Adoption of an incident learning system in a regionally expanding academic radiation oncology department Open
We observed significant increases in event reporting over a 6-year period across 5 regional sites within a large academic radiation oncology department, during which time we expanded and enhanced our safety and quality program, including r…
View article: Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review
Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review Open
As one of the largest systematic reviews examining RT for DIPG, this report may serve as a useful tool to help clinicians choose the most appropriate treatment approach, while also providing a platform for future investigations into the ut…
View article: Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial
Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial Open