Explanipedia

Impact of rapid pathogen identification of gram-negative anaerobic bacteria from blood cultures on antimicrobial stewardship Open

Nour Khankan, T Rust, Andrea Pallotta, Stephanie Bass, Christine Ramsey , et al. · 2025

Anaerobic bacteria are an important but understudied cause of bacteremia. The objective of this study was to evaluate the impact of using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to rapidl…

Molecular Adsorbent Recirculating System in Acute Liver Failure Open

Khaled Alsabbagh Alchirazi, Indira Bhavsar‐Burke, Hareem Syed, Motasem Alkhayyat, Stephanie Bass , et al. · 2024

Acetaminophen (APAP) overdose is the most common cause of acute liver failure (ALF) in the United States. Liver transplantation (LT) is potentially lifesaving for patients with ALF, but its feasibility in clinical practice is limited. Live…

Comparison of fungal vs bacterial infections in the medical intensive liver unit: Cause or corollary for high mortality? Open

Sarah Khan, Hanna Hong, Stephanie Bass, Yifan Wang, Xiaofeng Wang , et al. · 2024

BACKGROUND Due to development of an immune-dysregulated phenotype, advanced liver disease in all forms predisposes patients to sepsis acquisition, including by opportunistic pathogens such as fungi. Little data exists on fungal infection w…

Evaluation of a protocol for rifaximin discontinuation in critically ill patients with liver disease receiving broad-spectrum antibiotic therapy Open

Jessica Ward, Jason Yerke, Mollie Lumpkin, Aanchal Kapoor, Christina C. Lindenmeyer , et al. · 2023

BACKGROUND Rifaximin is frequently administered to critically ill patients with liver disease and hepatic encephalopathy, but patients currently or recently treated with antibiotics were frequently excluded from studies of rifaximin effica…

Evaluation of Dolutegravir- and Bictegravir-Based Antiretroviral Regimen Utilization in Patients who Cannot Take Medications by Mouth Open

Megan LoFaso, Olivia Marchionda, Stephanie Bass, Heather Torbic, Caitlin Blackewicz , et al. · 2023

A retrospective review of patients unable to take medications by mouth showed short interruptions of therapy for most patients. In a secondary analysis, our data showed maintenance and/or achievement of viral suppression for most patients.…

What is the role for terlipressin in hepatorenal syndrome? Open

Stephanie Bass, Aanchal Kapoor, Christina C. Lindenmeyer · 2023

The drug is recommended as a first-line treatment of hepatorenal syndrome-related acute kidney injury, but it is associated with respiratory failure, especially in the setting of albumin administration, and certain comorbidities may increa…

Peripheral Administration of Norepinephrine Open

Jason Yerke, Eduardo Mireles‐Cabodevila, Alyssa Y. Chen, Stephanie Bass, Anita Reddy , et al. · 2023

Which ICU patients need stress ulcer prophylaxis? Open

Mariam Saeed, Stephanie Bass, Neal F. Chaisson · 2022

Critically ill patients are at an increased risk for developing stress ulcers of the mucosa of the upper gastrointestinal (GI) tract. Bleeding from stress ulcers was previously associated with a longer stay in the intensive care unit and a…

Impact of Duration of N-Acetylcysteine in Non-Acetaminophen–Induced Acute Liver Failure Open

Stephanie Bass, Mollie Lumpkin, Eduardo Mireles‐Cabodevila, Christina C. Lindenmeyer, Bridget Dolan , et al. · 2021

OBJECTIVES: Studies of the use of IV N-acetylcysteine in the management of non-acetaminophen-induced acute liver failure have evaluated various dosing regimens. The only randomized trial studying this application described a 72-hour regime…

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages Open

Mahmoud Ammar, Gretchen L. Sacha, Sarah Welch, Stephanie Bass, Sandra L. Kane‐Gill , et al. · 2020

The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a spectrum of symptoms ranging from mild to critical illness requiring…

Bispectral Index for Titrating Sedation in ARDS Patients During Neuromuscular Blockade Open

Stephanie Bass, Mark L Vance, Anita Reddy, Seth R. Bauer, Erin Roach , et al. · 2019

Titration based on bispectral index did not result in a significant difference in sedation or analgesia exposure, or clinical outcomes, from that achieved with traditional sedation monitoring in patients with ARDS who were receiving a neur…

Effectiveness of venous thromboembolism prophylaxis in patients with liver disease Open

Jason Yerke, Seth R. Bauer, Stephanie Bass, Heather Torbic, Michael Militello , et al. · 2019

Pharmacological VTE prophylaxis was not associated with a significant reduction in the rate of VTE in patients with liver disease, though no increase in major bleeding events was observed.

2441. Outcomes of Patients With Vancomycin-Resistant Enterococcus Blood Stream Infections (BSI) Treated With Daptomycin Open

Luis Shimose, Maria X Bueno Rios, Vasilios Athans, Stephanie Bass, Manshi Li , et al. · 2018

BACKGROUND: Reports of poor outcomes in patients (patients) infected with VRE strains with daptomycin (DAP) minimum inhibitory concentrations (MIC) near the susceptible breakpoint (<=4 μg/ml) are noted in the literature. We assessed the re…

2444. Incidence of Daptomycin Toxicity Among Patients With Vancomycin-Resistant Enterococcus Blood Stream Infections Open

Maria X Bueno Rios, Luis Shimose, Vasilios Athans, Stephanie Bass, Joshua Otiso , et al. · 2018

BACKGROUND: Daptomycin (DAP) is a lipopeptide antibiotic and is first-line treatment for infections caused by Vancomycin-resistant Enterococcus (VRE). DAP is considered a safe antimicrobial agent, most commonly causing elevation of CPK. Th…

Predictors of response to fixed-dose vasopressin in adult patients with septic shock Open

Gretchen L. Sacha, Simon W. Lam, Abhijit Duggal, Heather Torbic, Stephanie Bass , et al. · 2018

Early Experience With Ceftazidime/Avibactam at an Academic Medical Center and Affiliated Health System Open

Kaitlyn Rivard, Elizabeth Neuner, Vasilios Athans, Andrea Pallotta, Seth R. Bauer , et al. · 2016

Clinical Experience With Ceftolozane/Tazobactam at a Large Academic Medical Center Open

Gretchen L. Sacha, Elizabeth Neuner, Vasilios Athans, Andrea Pallotta, Stephanie Bass , et al. · 2016

Influence of Colistin Dose on Global Cure in Patients with Bacteremia Due to Carbapenem-Resistant Gram-Negative Bacilli Open

Gabrielle Gibson, Seth R. Bauer, Elizabeth Neuner, Stephanie Bass, Simon W. Lam · 2015

The increasing prevalence of multidrug-resistant (MDR) nosocomial infections accounts for increased morbidity and mortality of such infections. Infections with MDR Gram-negative isolates are frequently treated with colistin. Based on recen…

High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients Open

Sarah Welch, Simon W. Lam, Elizabeth Neuner, Seth R. Bauer, Stephanie Bass · 2015

Impact of Combination Antimicrobial Therapy on Mortality Risk for Critically Ill Patients with Carbapenem-Resistant Bacteremia Open

Stephanie Bass, Seth R. Bauer, Elizabeth Neuner, Simon W. Lam · 2015

There are limited treatment options for carbapenem-resistant Gram-negative infections. Currently, there are suggestions in the literature that combination therapy should be used, which frequently includes antibiotics to which the causative…

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