Explanipedia

CRIMSON Open

Frank G. Holz, Adeline Adorf, Katharina Allgeier, Lebriz Altay, Christoph Johannes Arnholdt , et al. · 2025

Retinal degeneration driven by brain-derived neurotrophic factor deficiency in microglia and T-lymphocytes Open

Sabrina Reinehr, Julia P. Zehge, Katharina Klöster, Marcel Mueller, Hasan Hüsein Hendek , et al. · 2025

Neurodegenerative diseases, such as glaucoma or multiple sclerosis, are characterized by progressive neuronal loss involving diverse pathogenic mechanisms. The brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection…

Increased inflammation in older high-pressure glaucoma mice Open

Sabrina Reinehr, M Rahim Pamuk, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim · 2024

Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. βB1-Connective Tissue Growth Factor (βB1-CTGF) high-pressure glaucoma mice were used in this study to assess whet…

Retinal debris triggers cytotoxic damage in cocultivated primary porcine RPE cells Open

Natalie Wagner, Teresa Tsai, Sabrina Reinehr, Janine Theile, H. Burkhard Dick , et al. · 2024

Introduction One of the most common causes of vision loss in the elderly population worldwide is age-related macular degeneration (AMD). Subsequently, the number of people affected by AMD is estimated to reach approximately 288 million by …

Zellverlust bei retinaler Ischämie ist assoziiert mit vermehrter Nekroptose Open

Teresa Tsai, Leonie Deppe, H. Burkhard Dick, Stephanie C. Joachim · 2024

Protection against Oxidative Stress by Coenzyme Q10 in a Porcine Retinal Degeneration Model Open

Leonie Deppe, Ana M. Mueller‐Buehl, Teresa Tsai, Carl Erb, H. Burkhard Dick , et al. · 2024

Oxidative stress plays an important role in neurodegenerative diseases, including glaucoma. Therefore, we analyzed if the antioxidant coenzyme Q10 (CoQ10), which is also commercially available, can prevent retinal degeneration induced by h…

Does HSP27 injection induce glaucoma damage in mice? Open

Stephanie C. Joachim, Sabrina Reinehr · 2024

In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced Open

Sabrina Reinehr, Julien Wulf, Janine Theile, Kim K. Schulte, Marcus Peters , et al. · 2024

Background The neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combinat…

Glaucoma Animal Models beyond Chronic IOP Increase Open

Teresa Tsai, Sabrina Reinehr, Leonie Deppe, Alexandra Strubbe, Nils Kluge , et al. · 2024

Glaucoma is a complex and multifactorial disease defined as the loss of retinal ganglion cells (RGCs) and their axons. Besides an elevated intraocular pressure (IOP), other mechanisms play a pivotal role in glaucoma onset and progression. …

Neural extracellular matrix regulates visual sensory motor integration Open

Jacqueline Reinhard, Cornelius Mueller-Buehl, Susanne Wiemann, Lars Roll, Veronika Luft , et al. · 2024

Visual processing depends on sensitive and balanced synaptic neurotransmission. Extracellular matrix proteins in the environment of cells are key modulators in synaptogenesis and synaptic plasticity. In the present study, we provide eviden…

Investigation of Inter- and Intra-Day Variability of Tear Fluid Regarding Flow Rate, Protein Concentration as well as Protein Composition Open

Annika Guntermann, Oluwaseun Fatoba, Marc Kronenberg, Sabrina Reinehr, Pia Grotegut , et al. · 2023

Our findings provide evidence of inter-day variation in tear flow rate, tear proteome concentration, and composition in healthy subjects, suggesting that inter-day variation needs to be taken into consideration in biomarker research of tea…

HSP27 induced glaucomatous damage in mice of young and advanced age Open

C Erb, Sabrina Reinehr, Carsten Theiß, H. Burkhard Dick, Stephanie C. Joachim · 2023

Introduction Age-related diseases such as glaucoma, a leading cause of blindness, are having an upward trend due to an aging society. In glaucoma, some patients display altered antibody profiles and increased antibody titers, for example a…

Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone Open

Nousal Wergenthaler, H. Burkhard Dick, Teresa Tsai, Stephanie C. Joachim · 2023

The aim of this review was to identify a new potential explanation for the development of macular holes in relation to the female sex and to explain the possible underlying pathways. This approach was based on the evaluation of anatomical,…

Establishment of a primary porcine retinal pigment epithelium monolayer to complement retinal ex vivo cultures Open

Agnes Fietz, José Hurst, Stephanie C. Joachim, Sven Schnichels · 2023

Etiology of Idiopathic Macular Hole in the Light of Estrogen Hormone Open

Nousal Wergenthaler, H. Burkhard Dick, Teresa Tsai, Stephanie C. Joachim · 2023

The aim of this review was to identify a new potential reason for the development of macular holes in relation to the female sex and to explain the possible underlying pathway. This approach was based on the evaluation of anatomical, physi…

Teilnahme an einer klinischen Studie – Ist das etwas für mich? Open

Katrin Lorenz, Daniel Böhringer, Barbara Wilhelm, Sabine Aisenbrey, Katharina Allgeier , et al. · 2023

Neural extracellular matrix regulates visual sensory motor integration Open

Jacqueline Reinhard, Cornelius Mueller-Buehl, Susanne Wiemann, Lars Roll, Veronika Luft , et al. · 2023

SUMMARY Visual processing depends on sensitive and balanced synaptic neurotransmission. Extracellular matrix proteins in the environment of cells are key modulators in synaptogenesis and synaptic plasticity. In the present study, we provid…

Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy Open

Teresa Tsai, Mohannad Alwees, Mohammad Ali Asaad, Janine Theile, Vinodh Kakkassery , et al. · 2023

Background Diabetic retinopathy is a frequent complication of diabetes mellitus and a leading cause of blindness in adults. The objective of this study was to elucidate the diabetic retinopathy pathophysiology in more detail by comparing p…

Enhanced glaucomatous damage accompanied by glial response in a new multifactorial mouse model Open

Sabrina Reinehr, Renée M. Girbig, Kim K. Schulte, Janine Theile, Mohammad Ali Asaad , et al. · 2023

Introduction Glaucoma is a complex, multifactorial neurodegenerative disease, which can lead to blindness if left untreated. It seems that, among others, immune processes, elevated intraocular pressure (IOP), or a combination of these fact…

Editorial: Novel therapeutic approaches for the treatment of ocular disease, Volume II Open

Kyriaki Thermos, Stephanie C. Joachim · 2022

EDITORIAL article Front. Pharmacol., 01 December 2022Sec. Neuropharmacology Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1104105

Heat Shock Protein Upregulation Supplemental to Complex mRNA Alterations in Autoimmune Glaucoma Open

Sabrina Reinehr, Armin Safaei, Pia Grotegut, Annika Guntermann, Teresa Tsai , et al. · 2022

Glaucomatous optic neuropathy is a common cause for blindness. An elevated intraocular pressure is the main risk factor, but also a contribution of the immune system seems likely. In the experimental autoimmune glaucoma model used here, sy…

Impact of Primary RPE Cells in a Porcine Organotypic Co-Cultivation Model Open

Natalie Wagner, Armin Safaei, José Hurst, Pia A. Vogt, H. Burkhard Dick , et al. · 2022

The pathological events of age-related macular degeneration are characterized by degenerative processes involving the photoreceptor cells, retinal pigment epithelium (RPE), and the Bruch’s membrane as well as choroidal alterations. To mimi…

Towards an Understanding of Retinal Diseases and Novel Treatment Open

Stephanie C. Joachim · 2022

The Special Issue, “Towards an Understanding of Retinal Diseases and Novel Treatment”, provides comprehensive information on retinal diseases such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, retinitis pigment…

Changes of Subjective Symptoms and Tear Film Biomarkers following Femto-LASIK Open

Teresa Tsai, Mohannad Alwees, Anika Rost, Janine Theile, H. Burkhard Dick , et al. · 2022

Femtosecond laser-assisted in situ keratomileusis (Femto-LASIK) represents a common treatment modality in refractive surgery and shows excellent results in terms of safety, efficacy, predictability, and long-term stability. However, patien…

Wissenschaftliche Leistungen augenheilkundlicher Forschungseinrichtungen in Deutschland 2018 bis 2020 Open

Friederike Schaub, Birgit Mele, Philip Gass, Marius Ader, Horst Helbig , et al. · 2022

Protein Profiling of WERI-RB1 and Etoposide-Resistant WERI-ETOR Reveals New Insights into Topoisomerase Inhibitor Resistance in Retinoblastoma Open

Vinodh Kakkassery, Timo Gemoll, Miriam M. Kraemer, Thorben Sauer, Aysegül Tura , et al. · 2022

Chemotherapy resistance is one of the reasons for eye loss in patients with retinoblastoma (RB). RB chemotherapy resistance has been studied in different cell culture models, such as WERI-RB1. In addition, chemotherapy-resistant RB subclon…

Protein profiling of WERI RB1 and etoposide resistant WERI ETOR reveals new insights into topoisomerase inhibitor resistance in retinoblastoma Open

Vinodh Kakkassery, Timo Gemoll, Miriam M. Krämer, Thorben Sauer, Aysegül Tura , et al. · 2022

Chemotherapy resistance is one of the reasons for eye loss in patients with retinoblastoma (RB). RB chemotherapy resistance has been studied in different cell culture models such as WERI RB1. In addition, chemotherapy resistant RB subclone…

Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis Open

Laura Petrikowski, Sabrina Reinehr, Steffen Haupeltshofer, Leonie Deppe, Florian Graz , et al. · 2022

Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on…

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor Open

Daniel Hunziker, Sabrina Reinehr, Marina Palmhof, Natalie Wagner, Thomas Biniasch , et al. · 2022

The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration. A link to the pathogenesis of glaucoma is suggested by an overactive ATX-L…

Proteomic Analysis of Retinal Tissue in an S100B Autoimmune Glaucoma Model Open

Sabrina Reinehr, Annika Guntermann, Janine Theile, Lara Benning, Pia Grotegut , et al. · 2021

Glaucoma is a neurodegenerative disease that leads to damage of retinal ganglion cells and the optic nerve. Patients display altered antibody profiles and increased antibody titer, e.g., against S100B. To identify the meaning of these anti…

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