Explanipedia

Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model Open

Jinhong Meng, Shuang‐Gang Ma, Museer A. Lone, Hou Wang Lam, Qiang Zhang , et al. · 2025

Hereditary sensory neuropathy type IA (HSN1A) is a rare neurodegenerative condition caused by dominant mutations in the Serine Palmitoyl Transferase Long Chain base subunit 1 (SPTLC1) gene. There is no treatment available. Allele-specific …

Discrete and sequential critical periods organise the development of task-specific sensorimotor circuits in mice Open

Laura Andreoli, Antonia Maria Constantinescu, Abhijit Garai, Christopher J Black, Stephanie C. Koch · 2025

Somatosensory circuits in early life must maintain stable, task-selective pathways while behavioural repertoires undergo rapid change. How such circuits construct these behaviours under evolving functional demands has remained unclear. Her…

Ethologically relevant behavioural assay for investigating reach and grasp kinematics during whole-body motor control in mice Open

Christopher J. Black, Liam E. Browne, Robert M. Brownstone, Stephanie C. Koch · 2025

Reach and grasp are critical components of skilled mammalian motor control and their detailed analysis in rodents has been key to deepening our understanding of prehension in the context of health and disease. However, most studies investi…

Microglial Refinement of A-Fiber Projections in the Postnatal Spinal Cord Dorsal Horn Is Required for Normal Maturation of Dynamic Touch Open

Yajing Xu, Stephanie C. Koch, Alexander Chamessian, Qianru He, Mayya Sundukova , et al. · 2023

Sensory systems are shaped in postnatal life by the refinement of synaptic connectivity. In the dorsal horn of the spinal cord, somatosensory circuits undergo postnatal activity-dependent reorganization, including the refinement of primary…

Reliability and short version of the Dunphy Outcomes Framework (DOF): Integrating the art and science of dance movement therapy Open

Kim Dunphy, Paula Lebre, Ella Dumaresq, S.A. Schoenenberger-Howie, Josephine Geipel , et al. · 2023

There is an increasing requirement of evidence-based outcome frameworks in the health sciences. This article presents the Dunphy Outcomes Framework (DOF) for dance movement therapy (DMT), the first generic outcomes framework for DMT. The f…

Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization Open

D. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch, Kaya J.E. Matson , et al. · 2022

Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization Open

D. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch, Kaya J.E. Matson , et al. · 2022

Prolonged storage of purified granulocyte concentrates: Introduction of a new purification method Open

Gerd Klinkmann, Fanny Doß, Lilia Goudeva, Sandra Doß, Rainer Blasczyk , et al. · 2021

Background Use of donor granulocyte concentrate (GC) has been limited due to its short storage time of 6–24 h, which is partially due to residual red blood cells (RBCs) and platelets and the resulting lactate production leading to an acido…

A harmonized atlas of mouse spinal cord cell types and their spatial organization Open

D. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch, Kaya J.E. Matson , et al. · 2021

Microglial refinement of A-fibre projections in the postnatal spinal cord dorsal horn is required for normal maturation of dynamic touch Open

Yajing Xu, Stephanie C. Koch, Alexander Chamessian, Qianru He, Mayya Sundukova , et al. · 2021

Sensory systems are shaped in postnatal life by the refinement of synaptic connections. In the dorsal horn of the spinal cord, sensory circuits undergo postnatal activity dependent reorganisation, including the retraction of primary affere…

A Harmonized Atlas of Spinal Cord Cell Types and Their Computational Classification Open

D. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch, Kaya J.E. Matson , et al. · 2020

Single cell sequencing is transforming many fields of science but the vast amount of data it creates has the potential to both illuminate and obscure underlying biology. To harness the exciting potential of single cell data for the study o…

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait Open

Stephanie C. Koch, Marta Garcia Del Barrio, Antoine Dalet, Graziana Gatto, Thomas Günther , et al. · 2017

Spinal Circuits for Touch, Pain, and Itch Open

Stephanie C. Koch, David Acton, Martyn Goulding · 2017

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to …

Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments Open

Martin Sauer, Jens Altrichter, Cristof Haubner, Annette Pertschy, T. Cameron Wild , et al. · 2016

Purpose. Granulocyte transfusions have been used to treat immune cell dysfunction in sepsis. A granulocyte bioreactor for the extracorporeal treatment of sepsis was tested in a prospective clinical study focusing on the dosage of norepinep…

Gate control of mechanical itch by a subpopulation of spinal cord interneurons Open

Steeve Bourane, Bo Duan, Stephanie C. Koch, Antoine Dalet, Olivier Britz , et al. · 2015

A circuit controlling mechanical itch Considerable progress has been made in understanding and treating chemically induced itch. However, little is known about the mechanisms underlying mechanically evoked itch. Bourane et al. produced a m…

Identification of a Spinal Circuit for Light Touch and Fine Motor Control Open

Steeve Bourane, Katja S. Grossmann, Olivier Britz, Antoine Dalet, Marta Garcia Del Barrio , et al. · 2015

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