Explanipedia

Increased use of psychiatric medication following incident celiac autoimmunity Open

Quinn Goddard, Gilaad G. Kaplan, Stephanie Coward, Tyler Williamson, Scott B. Patten , et al. · 2025

These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG p…

A205 IMPACT OF THE PANDEMIC ON BUDESONIDE MMX DISPENSING AND TREATMENT FAILURE IN ULCERATIVE COLITIS Open

Stephanie Coward, Karen J. B. Martins, Scott Klarenbach, Karen I. Kroeker, Chaoran Ma , et al. · 2025

Background Budesonide MMX is a locally acting corticosteroid with reduced side effects compared to prednisone. During the pandemic, budesonide MMX may have been preferred due to its favourable side effect profile. Aims To analyze rates of …

A174 THE DIRECT HEALTHCARE COST OF INFLAMMATORY BOWEL DISEASE IN CANADA: A POPULATION-BASED ANALYSIS OF ADMINISTRATIVE DATA Open

Stephanie Coward, E I Benchimol, C N Bernstein, A. Aviña-Zubieta, Alain Bitton , et al. · 2025

Background The prevalence of inflammatory bowel disease (IBD) in Canada is rising rapidly, with an estimated 0.86% of the population living with IBD in 2025. With this rise in prevalence comes a rise in the direct costs to healthcare syste…

A61 GLOBAL INCIDENCE OF APPENDICITIS: A POPULATION-BASED STUDY OF THE ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT Open

E Buie, Stephanie Coward, Michael Buie, James A. King, Linda M. Wilson , et al. · 2025

Background The global incidence of appendicitis in 2019 was estimated at 228 per 100,000 person-years. However, temporal trends of appendicitis rates vary between early industrialized and newly industrialized regions. Aims To analyze annua…

A154 TEMPORAL TRENDS OF DEPRESSION HOSPITALIZATION AND SUICIDE DEATH IN THOSE WITH INFLAMMATORY BOWEL DISEASE Open

Ante Markovinović, Stephanie Coward, Christopher Ma, Abdel Aziz Shaheen, Gilaad G. Kaplan · 2025

Background Individuals with inflammatory bowel disease (IBD) are known to be more susceptible to mental health disorders such as depression. However, literature examining severe outcomes of depression in IBD, including hospitalizations due…

A181 GEOGRAPHIC IMPACT ON SCREENING AND DEVELOPMENT OF CERVICAL NEOPLASIA IN INFLAMMATORY BOWEL DISEASE Open

Quinn Goddard, Stephanie Coward, Cynthia H. Seow, Stefania Bertazzon, Gilaad G. Kaplan · 2025

Background While the risk of cancer in inflammatory bowel disease (IBD) is elevated, studies indicate a lower odds of gynecological cancers. Cervical cancer has become relatively preventable as a result of screening programs. However, geog…

A179 A CANADA-WIDE STUDY OF TRENDS IN HOSPITALIZATION RATES FOR INFLAMMATORY BOWEL DISEASE Open

Stephanie Coward, Eric I. Benchimol, C N Bernstein, A. Aviña-Zubieta, Alain Bitton , et al. · 2025

Background Hospitalizations among individuals with inflammatory bowel disease (IBD) place a strain on healthcare resources. The decline in hospitalization rates during the era of anti-TNF therapies remains debated in the literature. Aims T…

A135 INCREASED USE OF PSYCHIATRIC MEDICATION USE FOLLOWING DEVELOPMENT OF CELIAC DISEASE AUTOIMMUNITY Open

Quinn Goddard, James A. King, Stephanie Coward, Tyler Williamson, Gilaad G. Kaplan · 2025

Background Celiac disease (CeD) autoimmunity is characterized by new positivity for tissue transglutaminase antibodies (TTG) with or without pathologic confirmation. CeD autoimmunity is associated with an increased risk of psychiatric diso…

A65 HOSPITALIZATION RATES OF INFLAMMATORY BOWEL DISEASE DURING THE COVID-19 PANDEMIC: A POPULATION-BASED STUDY OF THE ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT. Open

Linda M. Wilson, James A. King, E Buie, Stephanie Coward, Abdel Aziz Shaheen , et al. · 2025

Background Inflammatory bowel disease (IBD) places a significant burden on healthcare resources, requiring medical and surgical management in hospital. The COVID-19 pandemic further strained healthcare systems, but the impact of the global…

A3 CELIAC DISEASE AUTOIMMUNITY INCREASING AMONG VARIOUS PEDIATRIC SUBGROUPS IN ALBERTA, CANADA Open

James A. King, Stephanie Coward, Jenny Godley, Amy Metcalfe, Paul E. Ronksley , et al. · 2025

Background Celiac disease (CeD) autoimmunity, defined as elevated tissue transglutaminase (TTG) levels with or without biopsy confirmation, is rising among children in Canada; however, further investigation is needed to understand if this …

A Population-Based Matched Cohort Study of Digestive System Cancer Incidence and Mortality in Individuals With and Without Inflammatory Bowel Disease Open

Sanjay K. Murthy, Parul Tandon, Priscilla Matthews, Faria Ahmed, Michael Pugliese , et al. · 2024

INTRODUCTION: To study digestive system cancer risks in individuals with inflammatory bowel diseases (IBDs) in the biologic era. METHODS: We used population-level administrative and cancer registry data from Ontario, Canada, (1994–2020) to…

Health Services Utilization and Specialist Care in Pediatric Inflammatory Bowel Disease: A Multiprovince Population-Based Cohort Study Open

M Ellen Kuenzig, Alain Bitton, Matthew Carroll, Anthony Otley, Harminder Singh , et al. · 2024

Background Patterns of health services utilization among children with inflammatory bowel disease (IBD) are important to understand as the number of children with IBD continues to increase. We compared health services utilization and surge…

A174 TESTING FOR AND INCIDENCE OF CELIAC DISEASE AUTOIMMUNITY SAW SIGNIFICANT BUT TEMPORARY DECLINES DURING COVID-19 PANDEMIC Open

James A. King, Stephanie Coward, Gilaad G. Kaplan, Tyler Williamson · 2024

Background Celiac disease (CD) is an autoimmune disorder with various complications and long-term health risks. The COVID-19 pandemic affected the entire healthcare system—including screening for and diagnosing non-infectious conditions. A…

Forecasting the Incidence and Prevalence of Inflammatory Bowel Disease: A Canadian Nationwide Analysis Open

Stephanie Coward, Eric I. Benchimol, Çharles N. Bernstein, Antonio Aviña-Zubieta, Alain Bitton , et al. · 2024

INTRODUCTION: Canada has a high burden of inflammatory bowel disease (IBD). Historical trends of IBD incidence and prevalence were analyzed to forecast the Canadian burden over the next decade. METHODS: Population-based surveillance cohort…

Variation in the Care of Children with Inflammatory Bowel Disease Within and Across Canadian Provinces: A Multi-Province Population-Based Cohort Study Open

M Ellen Kuenzig, Thérèse A. Stukel, Matthew Carroll, Gilaad G. Kaplan, Anthony Otley , et al. · 2024

There is variation in health services utilization among children with IBD and risk of undergoing intestinal resection in those with Crohn's disease, but not colectomy among children with ulcerative colitis, across Canadian pediatric tertia…

THE COST OF INFLAMMATORY BOWEL DISEASE: A POPULATION-BASED ANALYSIS OF ADMINISTRATIVE DATA Open

Stephanie Coward, Joseph W. Windsor, Eric I. Benchimol, Çharles N. Bernstein, Antonio Aviña-Zubieta , et al. · 2024

BACKGROUND As the global prevalence of inflammatory bowel disease (IBD) rises, it is important that the direst costs associated with medical care be analyzed to determine the impact on healthcare systems. Components making up the direct he…

EPIDEMIOLOGY OF INFLAMMATORY BOWEL DISEASE AMONG EARLY-INDUSTRIALIZED REGIONS OF THE WORLD: CHALLENGES IN SUSTAINABLE HEALTHCARE DELIVERY Open

Michelle Herauf, Stephanie Coward, Juan Nicolás Peña-Sánchez, Çharles N. Bernstein, Eric I. Benchimol , et al. · 2024

BACKGROUND Early-industrialized regions (e.g., North America, Europe, Oceania) are currently in stage 3 of the epidemiologic evolution of inflammatory bowel disease (IBD), compounding prevalence wherein incidence stabilizes, but prevalence…

TRENDS IN INFLAMMATORY BOWEL DISEASE INCIDENCE AND PREVALENCE ACROSS EPIDEMIOLOGIC STAGES: A GLOBAL SYSTEMATIC REVIEW WITH META-ANALYSIS Open

Julia Gorospe, Joseph W. Windsor, Lindsay Hracs, Stephanie Coward, Michael Buie , et al. · 2024

BACKGROUND Rising incidence and prevalence of inflammatory bowel disease (IBD) observed historically in early-industrialized regions now also appear in newly-industrialized and emerging regions. The epidemiology of IBD has been proposed to…

EXPLORING FACTORS ASSOCIATED WITH SEROLOGICAL RESPONSE TO SARS-COV-2 VACCINES IN INDIVIDUALS WITH INFLAMMATORY BOWEL DISEASE: INTERACTIVE VISUALIZATION METHODS FOR MULTIDIMENSIONAL DATA Open

Lindsay Hracs, Joshua Quan, Christopher Ma, Remo Panaccione, Nastaran Sharifi , et al. · 2024

BACKGROUND SARS-CoV-2 vaccine response may be reduced in seniors (age 65+) with inflammatory bowel disease (IBD) and those on anti-TNF therapy. A challenge of the COVID-19 era has been conveying rapid-evolving health information, especiall…

MODELING THE TRANSITION TO THE FOURTH EPIDEMIOLOGIC STAGE OF INFLAMMATORY BOWEL DISEASE: PREVALENCE EQUILIBRIUM Open

Joseph W. Windsor, Lindsay Hracs, K. Michael Cummings, Julia Gorospe, Michael Buie , et al. · 2024

BACKGROUND A theoretical framework for population-level transition across four epidemiologic stages has been proposed for inflammatory bowel disease (IBD): 1. Emergence (low incidence/prevalence); 2. Acceleration in Incidence (rapid rising…

MACHINE LEARNING CLASSIFICATION OF THE EPIDEMIOLOGIC STAGES OF INFLAMMATORY BOWEL DISEASE ACROSS GEOGRAPHY AND TIME Open

Lindsay Hracs, Joseph W. Windsor, Julia Gorospe, Michael Buie, Joshua Quan , et al. · 2024

BACKGROUND Epidemiologic stages of inflammatory bowel disease (IBD) have been proposed: 1. Emergence (low incidence and prevalence); 2. Acceleration in Incidence (rapidly rising incidence, low prevalence); and 3. Compounding Prevalence (st…

The Global Evolution of Inflammatory Bowel Disease across Four Epidemiologic Stages Open

Gilaad G. Kaplan, Lindsay Hracs, Joseph W. Windsor, Julia Gorospe, K. Michael Cummings , et al. · 2024

During the 20th century, inflammatory bowel disease (IBD) was considered a disease of early-industrialized regions in North America, Europe, and Oceania. At the turn of the 21st century, incidence of IBD increased in newly-industrialized a…

Incidence and Prevalence of Primary Sclerosing Cholangitis: A Meta-analysis of Population-based Studies Open

Jared Cooper, Ante Markovinović, Stephanie Coward, Michelle Herauf, Abdel Aziz Shaheen , et al. · 2023

Background Primary sclerosing cholangitis is a chronic liver disease associated with significant morbidity, mortality, and healthcare utilization. We conducted a systematic review and meta-analysis of population-based studies of the incide…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Direct Health System and Medication Costs Open

M Ellen Kuenzig, Stephanie Coward, Laura E. Targownik, Sanjay K. Murthy, Eric I. Benchimol , et al. · 2023

Healthcare utilization among people living with inflammatory bowel disease (IBD) in Canada has shifted from inpatient management to outpatient management; fewer people with IBD are admitted to hospitals or undergo surgery, but outpatient v…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Indirect (Individual and Societal) and Direct Out-of-Pocket Costs Open

M Ellen Kuenzig, James Im, Stephanie Coward, Joseph W. Windsor, Gilaad G. Kaplan , et al. · 2023

People living with inflammatory bowel disease (IBD) and their caregivers are faced with indirect and out-of-pocket costs that they would not otherwise experience. These costs impact one’s ability to contribute to the economy to their fulle…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Special Populations—Children and Adolescents with IBD Open

Wael El‐Matary, Matthew Carroll, Colette Deslandres, Anne M. Griffiths, M Ellen Kuenzig , et al. · 2023

Rates of inflammatory bowel disease (IBD) in Canadian children and adolescents are among the highest in the world, and the incidence is rising most rapidly in children under five years of age. These young children may have either a typical…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Treatment Landscape Open

Sanjay K. Murthy, Adam V. Weizman, M Ellen Kuenzig, Joseph W. Windsor, Gilaad G. Kaplan , et al. · 2023

The therapeutic landscape for inflammatory bowel disease (IBD) has changed considerably over the past two decades, owing to the development and widespread penetration of targeted therapies, including biologics and small molecules. While so…

The 2023 Impact of Inflammatory Bowel Disease in Canada: COVID-19 and IBD Open

Gilaad G. Kaplan, M Ellen Kuenzig, Joseph W. Windsor, Çharles N. Bernstein, Alain Bitton , et al. · 2023

The COVID-19 pandemic had a monumental impact on the inflammatory bowel disease (IBD) community. At the beginning of the pandemic, knowledge on the effect of SARS-CoV-2 on IBD was lacking, especially in those with medication-suppressed imm…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Cancer and IBD Open

Sanjay K. Murthy, M Ellen Kuenzig, Joseph W. Windsor, Priscilla Matthews, Parul Tandon , et al. · 2023

Cancer is a major cause of morbidity and mortality among people with inflammatory bowel disease (IBD). Intestinal cancers may arise as a complication of IBD itself, while extra-intestinal cancers may arise due to some of the immunosuppress…

The 2023 Impact of Inflammatory Bowel Disease in Canada: Epidemiology of IBD Open

Stephanie Coward, Eric I. Benchimol, M Ellen Kuenzig, Joseph W. Windsor, Çharles N. Bernstein , et al. · 2023

Inflammatory bowel disease (IBD), consisting of Crohn’s disease and ulcerative colitis, is recognized across the world, though Canada has among the highest burdens of IBD in the world. The Canadian Gastro-Intestinal Epidemiology Consortium…

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