Stephanie E. Ander
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Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice Open
Previously, we found that chimeric Sindbis-eastern equine encephalitis virus (SINV-EEEV) particles can be removed from the murine blood circulation in a phagocyte-dependent manner which can be disrupted by either transient depletion of vas…
A 44-Nucleotide Region in the Chikungunya Virus 3′ UTR Dictates Viral Fitness in Disparate Host Cells Open
We previously reported that deletion of a 44-nucleotide element in the 3′ untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here, we find that while this 44-nucleotide dele…
A 44-Nucleotide Region in the Chikungunya Virus 3′ UTR Dictates Viral Fitness in Disparate Host Cells Open
We previously reported that deletion of a 44-nucleotide element in the 3′ untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here, we find that while this 44-nucleotide dele…
Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner Open
The magnitude and duration of vertebrate viremia are critical determinants of arbovirus transmission, geographic spread, and disease severity—yet, mechanisms determining arbovirus viremia levels are poorly defined. Previous studies have dr…
Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner Open
The magnitude and duration of vertebrate viremia are critical determinants of arbovirus transmission, geographic spread, and disease severity—yet, mechanisms determining arbovirus viremia levels are poorly defined. Previous studies have dr…
Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream Open
Many viruses utilize the lymphohematogenous route for dissemination; however, they may not freely use this highway unchecked. The reticuloendothelial system (RES) is an innate defense system that surveys circulating blood, recognizing and …
Defining the Placental Barrier during Toxoplasma gondii Infection Open
Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal…
View article: Immune responses at the maternal-fetal interface
Immune responses at the maternal-fetal interface Open
The placenta promotes tolerance of the semiallogeneic fetus while protecting against vertical transmission of infections.
Human Placental Syncytiotrophoblasts Restrict <i>Toxoplasma gondii</i> Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines Open
Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal…
Human placental syncytiotrophoblasts restrict <i>Toxoplasma gondii</i> vertical transmission at two distinct stages and induce CCL22 in response to infection Open
Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal…
Protein Composition of the Bovine Herpesvirus 1.1 Virion Open
Bovine herpesvirus (BoHV) type 1 is an important agricultural pathogen that infects cattle and other ruminants worldwide. Acute infection of the oro-respiratory tract leads to immune suppression and allows commensal bacteria to infect an o…