Stephanie E. Brown
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View article: Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation
Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation Open
Background Neurodevelopmental disorders (NDDs) can cause debilitating impairments in social cognition and aberrant functional connectivity in large-scale brain networks, leading to social isolation and diminished everyday functioning. To f…
View article: d-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation
d-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation Open
The proper development and function of telencephalic GABAergic interneurons is critical for maintaining the excitation and inhibition (E/I) balance in cortical circuits. Glutamate contributes to cortical interneuron (CIN) development via N…
View article: Inhibition of glial D‐serine release rescues synaptic damage after brain injury
Inhibition of glial D‐serine release rescues synaptic damage after brain injury Open
Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much of the associated cognitive dysfunction; however, it is poorly understood. The D‐amino acid, D‐serine, serves as the prima…
View article: Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells
Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells Open
Summary Cell cycle progression follows a precise sequence of events marked by different phases and checkpoints which are associated with specific chromatin organisation. Whilst these changes have been extensively studied, their consequence…
View article: Conditional Manipulation of Gene Function in Human Cells with Optimized Inducible shRNA
Conditional Manipulation of Gene Function in Human Cells with Optimized Inducible shRNA Open
The difficulties involved in conditionally perturbing complex gene expression networks represent major challenges toward defining the mechanisms controlling human development, physiology, and disease. We developed an OPTimized inducible Kn…