Sarah M. King
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View article: Pharmacoepigenetic Biomarkers in Inflammatory Bowel Diseases: ANarrative Review
Pharmacoepigenetic Biomarkers in Inflammatory Bowel Diseases: ANarrative Review Open
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, autoimmune disorder characterized by inflammation along the gastrointestinal tract. Global prevalence of the disease is increasi…
View article: Toxicity of crude oil-derived polar unresolved complex mixtures to Pacific herring embryos: Insights beyond polycyclic aromatic hydrocarbons
Toxicity of crude oil-derived polar unresolved complex mixtures to Pacific herring embryos: Insights beyond polycyclic aromatic hydrocarbons Open
Crude oil toxicity to early life stage fish is commonly attributed to polycyclic aromatic hydrocarbons (PAHs). However, it remains unclear how the polar unresolved complex mixture (UCM), which constitutes the bulk of the water-soluble frac…
View article: TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway
TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway Open
These findings demonstrate a role for TOMM40 in regulating hepatic lipid and plasma lipoprotein levels and identify mechanisms linking mitochondrial function with lipid metabolism.
View article: Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study
Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study Open
Circulating levels of the soluble ligand-binding ectodomain of the LDL receptor (sLDLR) that is proteolytically cleaved from the cell surface have been shown to correlate with plasma triglycerides, but the lipid and lipoprotein effects of …
View article: Missense variants in SORT1 are associated with LDL-C in an Amish population
Missense variants in SORT1 are associated with LDL-C in an Amish population Open
Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies. However, validation st…
View article: Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse population
Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse population Open
Despite great progress in understanding lipoprotein physiology, there is still much to be learned about the genetic drivers of lipoprotein abundance, composition, and function. We used ion mobility spectrometry to survey 16 plasma lipoprot…
View article: Social and Ecological Drivers of Behavior that Prevents Aquatic Invasive Species Transport
Social and Ecological Drivers of Behavior that Prevents Aquatic Invasive Species Transport Open
Aquatic invasive species (AIS) have caused widespread damage to environmental and socio-economic systems across the globe. One vector of biological invasions is recreational boaters who are at risk of unintentionally introducing AIS when m…
View article: Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response Open
Background Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that r…
View article: The small HDL particle hypothesis of Alzheimer's disease
The small HDL particle hypothesis of Alzheimer's disease Open
We propose the hypothesis that small high‐density lipoprotein (HDL) particles reduce the risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting neuronal membrane composition and vascular and synaptic fun…
View article: Effects of Palm Stearin versus Butter in the Context of Low-Carbohydrate/High-Fat and High-Carbohydrate/Low-Fat Diets on Circulating Lipids in a Controlled Feeding Study in Healthy Humans
Effects of Palm Stearin versus Butter in the Context of Low-Carbohydrate/High-Fat and High-Carbohydrate/Low-Fat Diets on Circulating Lipids in a Controlled Feeding Study in Healthy Humans Open
Background. Foods rich in saturated fatty acids (SFAs) have been discouraged by virtue of their cholesterol-raising potential, but this effect is modulated by the food source and background level of carbohydrate. Objective. We aimed to com…
View article: Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes
Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes Open
Background We have previously reported that in patients with type 2 diabetes (T2D) consumption of a very low carbohydrate diet capable of inducing nutritional ketosis over 2 years (continuous care intervention, CCI) resulted in improved bo…
View article: Impact of A Two-Year Trial of Nutritional Ketosis on Indices of Cardiovascular Disease Risk in Patients With Type 2 Diabetes
Impact of A Two-Year Trial of Nutritional Ketosis on Indices of Cardiovascular Disease Risk in Patients With Type 2 Diabetes Open
Background: We have previously reported that in patients with type 2 diabetes (T2D) consumption of a very low carbohydrate diet capable of inducing nutritional ketosis over two years (continuous care intervention, CCI) resulted in improved…
View article: Research and Analysis of Fisheries in Illinois Final Performance Report 1 July 2019 – 30 June 2020
Research and Analysis of Fisheries in Illinois Final Performance Report 1 July 2019 – 30 June 2020 Open
Project F-69-R has three overall goals: (1) conduct a wide variety of surveys and investigations that elucidate patterns of variation in sport fish populations and the mechanisms that drive those patterns, (2) communicate research findings…
View article: Research and Analysis of Fisheries in Illinois F-69-R (32) Final Performance Report July 1, 2018 – June 30, 2019
Research and Analysis of Fisheries in Illinois F-69-R (32) Final Performance Report July 1, 2018 – June 30, 2019 Open
Fisheries managers are charged with understanding the interaction between sport fish
\npopulations and anglers to inform resource management decision making that supports and
\npromotes healthy fisheries. Fundamental to this mission is eas…
View article: O3‐01‐01: INTERACTION BETWEEN OBESITY, BRAIN HDL, AND APOE4 GENOTYPE IN CEREBRAL AMYLOIDOSIS
O3‐01‐01: INTERACTION BETWEEN OBESITY, BRAIN HDL, AND APOE4 GENOTYPE IN CEREBRAL AMYLOIDOSIS Open
Apolipoprotein E4 (APOE4), obesity and low HDL cholesterol in plasma are risk factors for the development of late-onset Alzheimer's disease (AD) and brain amyloidosis. However, the responsible mechanisms are not clearly understood. We hypo…
View article: Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates
Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates Open
Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism.…
View article: Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or ApoC3 RNA interference
Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or ApoC3 RNA interference Open
Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil (FO) reduces plasma lipids. Diet-induced dyslipidemia in a rhesus model better approximates the pathophysiolog…
View article: Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance
Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance Open
Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both …