Stephanie E. Simonds
YOU?
Author Swipe
View article: Effects of a single dose of psilocybin on diet-induced weight loss in obese mice
Effects of a single dose of psilocybin on diet-induced weight loss in obese mice Open
Prolonged obesity induces enduring structural changes within neural circuits that contribute to maintaining the body at an elevated/obese body weight. These circuits regulate various mechanisms which can inhibit extreme or persistent weigh…
View article: α-Melanocyte Stimulating Hormone Reduces Blood Glucose Across Species
α-Melanocyte Stimulating Hormone Reduces Blood Glucose Across Species Open
Peripheral administration of α-melanocyte stimulating hormone (α-MSH) promotes glucose uptake in skeletal muscle via a melanocortin 5 receptor (MC5R)-dependent mechanism in rodents. Here we demonstrate that this pathway is functional in hu…
View article: The Physiological Effects of Air Pollution: Particulate Matter, Physiology and Disease
The Physiological Effects of Air Pollution: Particulate Matter, Physiology and Disease Open
Nine out of 10 people breathe air that does not meet World Health Organization pollution limits. Air pollutants include gasses and particulate matter and collectively are responsible for ~8 million annual deaths. Particulate matter is the …
View article: Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity
Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity Open
Experimental non-human primate models of obesity are induced through the introduction of atypically calorically rich diets. Studies in captive-bred macaques show the development of obesity and diabetes with similar complications to humans …
View article: Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456–2465
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456–2465 Open
In the article listed above, ERX was erroneously omitted from the duality of interest for Matthias H. …
View article: Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus Open
Celastrol is a natural pentacyclic triterpene used in traditional Chinese medicine with significant weight-lowering effects. Celastrol-administered mice at 100 μg/kg decrease food consumption and body weight via a leptin-dependent mechanis…
View article: Insulin regulates POMC neuronal plasticity to control glucose metabolism
Insulin regulates POMC neuronal plasticity to control glucose metabolism Open
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activat…
View article: Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1 Open
Celastrol, a plant-derived constituent of traditional Chinese medicine, has been proposed to offer significant potential as an antiobesity drug. However, the molecular mechanism for this activity is unknown. We show that the weight-lowerin…
View article: Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons
Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons Open
POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons. Inhibition o…
View article: Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss Open
These data show a novel central anti-obesity mechanism of action of DNP and highlight the potential for selective melanocortin mitochondrial uncoupling to target metabolic disorders.
View article: Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling
Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling Open
Mutations in the Nkx2-5 gene are a main cause of congenital heart disease. Several studies have addressed the phenotypic consequences of disrupting the Nkx2-5 gene locus, although animal models to date failed to recapitulate the full spect…
View article: The role of fat mass on the development of secondary diseases; specifically the impact of elevated leptin concentration on the development of hypertension
The role of fat mass on the development of secondary diseases; specifically the impact of elevated leptin concentration on the development of hypertension Open
Obesity and the excessive accumulation of body fat is associated with significant chronic secondary diseases including, cardiovascular diseases, cancers and diabetes. Obesity and its associated diseases are becoming huge economic and socia…
View article: α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors Open
These data describe a novel endocrine circuit that modulates glucose homeostasis by pituitary α-MSH, which increases muscle glucose uptake and thermogenesis through the activation of a MC5R-PKA-pathway, which is disrupted in obesity.