Explanipedia

Freeze-FRESH: A 3D Printing Technique to Produce Biomaterial Scaffolds with Hierarchical Porosity Open

Zi Wang, Stephen J. Florczyk · 2020

Tissues are organized in hierarchical structures comprised of nanoscale, microscale, and macroscale features. Incorporating hierarchical structures into biomaterial scaffolds may enable better resemblance of native tissue structures and im…

Direct-Contact Cytotoxicity Evaluation of CoCrFeNi-Based Multi-Principal Element Alloys Open

Ryan Newell, Zi Wang, I. Ruiz Arias, Abhishek Mehta, Yongho Sohn , et al. · 2018

Transition metal multi-principal element alloys (MPEAs) are novel alloys that may offer enhanced surface and mechanical properties compared with commercial metallic alloys. However, their biocompatibility has not been investigated. In this…

Modeling, validation and verification of three-dimensional cell-scaffold contacts from terabyte-sized images Open

Peter Bajcsy, Soweon Yoon, Stephen J. Florczyk, Nathan Hotaling, Mylene Simon , et al. · 2017

Effect of the scaffold microenvironment on cell polarizability and capacitance determined by probabilistic computations Open

Beatriz A. Pazmiño Betancourt, Stephen J. Florczyk, Mylene Simon, Derek Juba, Jack F. Douglas , et al. · 2017

In living systems, it is frequently stated that form follows function by virtue of evolutionary pressures on organism development, but in the study of how functions emerge at the cellular level, function often follows form. We study this c…

A Bioinformatics 3D Cellular Morphotyping Strategy for Assessing Biomaterial Scaffold Niches Open

Stephen J. Florczyk, Mylene Simon, Derek Juba, P. Scott Pine, Sumona Sarkar , et al. · 2017

Many biomaterial scaffolds have been advanced to provide synthetic cell niches for tissue engineering and drug screening applications; however, current methods for comparing scaffold niches focus on cell functional outcomes or attempt to n…

Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues Open

Desu Chen, Sumona Sarkar, Julián Candia, Stephen J. Florczyk, Subhadip Bodhak , et al. · 2016

3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells Open

Stephen J. Florczyk, Forrest M. Kievit, Kui Wang, Ariane E. Erickson, Richard G. Ellenbogen , et al. · 2016

3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells for various cell types including breast, liver, and prostate cancer.

3D Porous Chitosan–Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer Open

Kui Wang, Forrest M. Kievit, Stephen J. Florczyk, Zachary R. Stephen, Miqin Zhang · 2015

Cationic nanoparticles (NPs) for targeted gene delivery are conventionally evaluated using 2D in vitro cultures. However, this does not translate well to corresponding in vivo studies because of the marked difference in NP behavior in the …

A method for the evaluation of thousands of automated 3D stem cell segmentations Open

Peter Bajcsy, Mylene Simon, Stephen J. Florczyk, Carl G. Simon, Derek Juba , et al. · 2015

Summary There is no segmentation method that performs perfectly with any dataset in comparison to human segmentation. Evaluation procedures for segmentation algorithms become critical for their selection. The problems associated with segme…

CHITOSAN-ALGINATE SCAFFOLD CELLCULTURE SYSTEM AND RELATEDMETHODS Open

Miqin Zhang, Forrest M. Kievit, Matthew Leung, Stephen J. Florczyk · 2015

Methods for culturing cancer cells in vitro using a three dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds that include the cultured cancer cells in a…

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