Stephanie Kreis
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View article: High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma
High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma Open
Background Despite significant advances in targeted (BRAFi + MEKi) and immune (anti-PD1/PD-L1, anti-CTLA4, and anti-LAG3) therapies, treatment options for NRAS mut melanoma remain limited. Currently, NRAS mut patients rely on immune checkp…
View article: High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma
High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma Open
Background Despite significant advances in targeted (BRAFi + MEKi) and immune (anti-PD1/PD-L1, anti-CTLA4, and anti-LAG3) therapies, treatment options for NRASmut melanoma remain limited. Currently, NRASmut patients r…
View article: Innovative 3D multicomponent melanoma models for in vitro drug screening
Innovative 3D multicomponent melanoma models for in vitro drug screening Open
View article: High-throughput screening of advanced multicomponent pre-clinical 3D melanoma models identifies potential first-line targeted therapies for NRAS mutant melanoma
High-throughput screening of advanced multicomponent pre-clinical 3D melanoma models identifies potential first-line targeted therapies for NRAS mutant melanoma Open
View article: Targeting Drug-Tolerant Persister Cells in NRAS-Mutant: A 3D Model-Based Approach for Identifying Novel Therapeutics
Targeting Drug-Tolerant Persister Cells in NRAS-Mutant: A 3D Model-Based Approach for Identifying Novel Therapeutics Open
View article: Protocol to generate scaffold-free, multicomponent 3D melanoma spheroid models for preclinical drug testing
Protocol to generate scaffold-free, multicomponent 3D melanoma spheroid models for preclinical drug testing Open
Three-dimensional (3D) models play an increasingly important role in preclinical drug testing as they faithfully mimic interactions between cancer cells and the tumor microenvironment (TME). Here, we present a protocol for generating scaff…
View article: A cytosolic mutp53(E285K) variant confers chemoresistance of malignant melanoma
A cytosolic mutp53(E285K) variant confers chemoresistance of malignant melanoma Open
Malignant melanoma (MM) is known to be intrinsically chemoresistant, even though only ~20% of MM carry mutations of the tumor suppressor p53. Despite improvement of systemic therapy the mortality rate of patients suffering from metastatic …
View article: TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES
TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES Open
Melanoma has a high propensity for brain metastasis, occurring in 40% of late-stage patients. The progression of secondary tumors in the brain depends on the support of the surrounding microenvironment, emphasizing the importance of modula…
View article: Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes Open
Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late‐stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis establishment, cell s…
View article: Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma
Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma Open
Despite high initial response rates to targeted kinase inhibitors, the majority of patients suffering from metastatic melanoma present with high relapse rates, demanding for alternative therapeutic options. We have previously developed a d…
View article: A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma
A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma Open
Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown to be reversible and cells escaping senescence further enhance the aggressiveness of cancers. Chemicals specificall…
View article: Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response Open
Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient targeted drug combination that significantly increases overall and progression-free survival. In addition, targeted therapy success is hampered by t…
View article: Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Data from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Data from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Small noncoding microRNAs (miRNA) regulate the expression of target mRNAs by repressing their translation or orchestrating their sequence-specific degradation. In this study, we investigated miRNA and miRNA target gene expression patterns …
View article: Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Figure 2 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Table 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Data from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Data from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Small noncoding microRNAs (miRNA) regulate the expression of target mRNAs by repressing their translation or orchestrating their sequence-specific degradation. In this study, we investigated miRNA and miRNA target gene expression patterns …
View article: Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma Open
Supplementary Table and Figure Legends, Material and Methods from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
View article: A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma
A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma Open
Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown to be reversible and cells escaping senescence further enhance the aggressiveness of cancers. Together with targete…
View article: MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression
MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression Open
Uveal melanoma (UM) is a rare type of malignancy that originates from melanocytes in the choroid, iris and the eye’s ciliary body. Biomarkers for early detection and progression of UM, especially the molecular traits governing the developm…
View article: P12.09.B Extracellular vesicle derived-miR-146a increases melanoma brain metastasis progression via Notch signalling pathway dysregulation
P12.09.B Extracellular vesicle derived-miR-146a increases melanoma brain metastasis progression via Notch signalling pathway dysregulation Open
Background Melanoma has the highest tropism of any cancer to metastasize to the brain, and 40% of late-stage patients develop brain metastasis. Invasion, survival, and progression of tumors is dependent on the support of the surrounding mi…
View article: Single-Cell Transcriptomics of Distinct Cell States in NRAS-Mutated Melanoma Transitioning to Drug Resistance: Elevated P2RX7 Levels Indicate Response to Targeted Therapy
Single-Cell Transcriptomics of Distinct Cell States in NRAS-Mutated Melanoma Transitioning to Drug Resistance: Elevated P2RX7 Levels Indicate Response to Targeted Therapy Open
View article: Continuous Cooling Crystallization in a Coiled Flow Inverter Crystallizer Technology—Design, Characterization, and Hurdles
Continuous Cooling Crystallization in a Coiled Flow Inverter Crystallizer Technology—Design, Characterization, and Hurdles Open
Continuous small-scale production is currently of utmost interest for fine chemicals and pharmaceuticals. For this purpose, equipment and process concepts in consideration of the hurdles for solids handling are required to transfer convent…
View article: Neutrophils in Tumorigenesis: Missing Targets for Successful Next Generation Cancer Therapies?
Neutrophils in Tumorigenesis: Missing Targets for Successful Next Generation Cancer Therapies? Open
Neutrophils—once considered as simple killers of pathogens and unexciting for cancer research—are now acknowledged for their role in the process of tumorigenesis. Neutrophils are recruited to the tumor microenvironment where they turn into…
View article: NRAS mutant melanoma: Towards better therapies
NRAS mutant melanoma: Towards better therapies Open
View article: Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells
Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells Open
MicroRNAs are key post-transcriptional gene regulators often displaying aberrant expression patterns in cancer. As microRNAs are promising disease-associated biomarkers and modulators of responsiveness to anti-cancer therapies, a solid und…