Nicole Phillips
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View article: Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment
Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment Open
The proposed model yields reproducible precision across 15 data configurations. This approach demonstrates the effectiveness of representation learning in enhancing biological signals by mitigating acquisition-specific confounding factors …
View article: Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression
Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression Open
View article: Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population
Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population Open
The study highlights a further aspect of the pathophysiological mechanisms involved in the brain-body communication. While IL-6 partially explains statistical associations between chronic emotional stress and major cardiometabolic disorder…
View article: Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses
Gestational chronic intermittent hypoxia triggers maternal inflammation and disrupts placental stress responses Open
Late-gestation exposure to even mild, short-term, chronic intermittent hypoxia (CIH) is sufficient to initiate maternal inflammation and disrupt key placental stress response mechanisms, despite occurring after placental development is lar…
View article: Heritable Tissue‐Specific Gene Expression Associates With Chronic Wound Microbial Species
Heritable Tissue‐Specific Gene Expression Associates With Chronic Wound Microbial Species Open
The reasons for interpatient variability in chronic wound microbiome composition are thought to be complex but are poorly known. To investigate how patients' genetically regulated tissue expression may influence chronic wound bacterial com…
View article: Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses
Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses Open
Gestational hypoxia is associated with placental cellular responses, including oxidative stress and inflammation. Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a marker of cell stress, that can be transported within extracellular …
View article: miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease
miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease Open
MicroRNAs (miRNAs) are small non-coding RNA molecules that are known to regulate gene expression in their target locations thereby contributing to epigenetic mechanisms associated with disease pathologies. Dysregulation of miRNA activity h…
View article: Mito Stress Assay of PBMCs With Seahorse XFe96 Flux Analyzer and Comparison of Poly-D-Lysine and Poly-L-Lysine for Cell Affinity
Mito Stress Assay of PBMCs With Seahorse XFe96 Flux Analyzer and Comparison of Poly-D-Lysine and Poly-L-Lysine for Cell Affinity Open
The Seahorse 96 XF Analyzer (Agilent Technologies, Santa Clara, CA, USA) has been an effective tool in non-invasively measuring mitochondrial function for the past decade. It is a high-throughput respirometer that is considered the "gold s…
View article: Association between everyday perceived discrimination and cognitive function as mediated by depression in diverse populations: A HABS‐HD Study
Association between everyday perceived discrimination and cognitive function as mediated by depression in diverse populations: A HABS‐HD Study Open
Background Previous research suggests that perceived discrimination is associated with cognitive function impairment, and such association is mediated by depression. With minority populations continuously growing, it is crucial to investig…
View article: Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders
Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders Open
Importance Determining the influence of race and ethnicity on change in cognitive test performance has significant implications for clinical practice and research in populations at risk for Alzheimer disease. Objective To evaluate the sign…
View article: Influence of Diet on Reproducible Corticosterone Levels in a Mouse Model of Maternal Separation with Early Weaning
Influence of Diet on Reproducible Corticosterone Levels in a Mouse Model of Maternal Separation with Early Weaning Open
Maternal separation with early weaning (MSEW) is a popular early life stress (ELS) model in rodents, which emulates childhood neglect through scheduled mother-offspring separation. Although variations of ELS models, including maternal sepa…
View article: Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress
Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress Open
This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo glaucoma models. Primary retinal ganglion cells (RGCs) were…
View article: Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related Risk
Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related Risk Open
Background: Age is known to be the biggest risk factor for Alzheimer’s disease (AD), and Mexican Americans (MAs), who are one of the fastest-aging populations in the United States, are at a uniquely elevated risk. Mitochondrial stress and …
View article: Differences in Genetic Ancestry Explain Variation in APOE Risk of Alzheimer's Disease Among 12,221 Caribbean-Hispanic, Mexican, Mexican-American, Peruvian and Bolivians Individuals
Differences in Genetic Ancestry Explain Variation in APOE Risk of Alzheimer's Disease Among 12,221 Caribbean-Hispanic, Mexican, Mexican-American, Peruvian and Bolivians Individuals Open
View article: Epigenome‐Wide‐Association‐Scan Reveals Epigenetic Profile Changes Using Neurofilament Light as a Neurodegeneration Proxy Biomarker in Mexican Americans
Epigenome‐Wide‐Association‐Scan Reveals Epigenetic Profile Changes Using Neurofilament Light as a Neurodegeneration Proxy Biomarker in Mexican Americans Open
Background Recent literature shows Alzheimer’s Disease (AD) has both genetic and epigenetic components resulting in disease manifestation. Furthering our prior work on AD epigenetics in the Health and Aging Brain Study – Health Disparities…
View article: FedExosome: profiling AD‐related mitochondrial DNA and microRNAs isolated from neuronal‐enriched peripheral blood packages
FedExosome: profiling AD‐related mitochondrial DNA and microRNAs isolated from neuronal‐enriched peripheral blood packages Open
Background Alzheimer’s disease (AD) is a complex disease characterized by impaired memory, diminished cognition, and specific brain pathology (i.e., accumulation of amyloid beta plaques and tau tangles). AD progression is often difficult t…
View article: Association of APOE with Alzheimer’s disease in Mexico, Caribbean‐Hispanics, Peruvian and Mexican Americans
Association of APOE with Alzheimer’s disease in Mexico, Caribbean‐Hispanics, Peruvian and Mexican Americans Open
Background The Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for Late Onset Alzheimer’s disease (LOAD). However, its genetic effect is heterogeneous across different ethnicities. We investigated the association of …
View article: Interaction between DNA methylation and neighborhood disadvantage may impact risk for cognitive decline among Mexican Americans enrolled in the Health and Aging Brain Study – Health Disparities (HABS‐HD) Cohort
Interaction between DNA methylation and neighborhood disadvantage may impact risk for cognitive decline among Mexican Americans enrolled in the Health and Aging Brain Study – Health Disparities (HABS‐HD) Cohort Open
Background Literature continues to indicate that social exposome factors such as neighborhood disadvantage, measured by the area deprivation index (ADI), is associated with cognitive decline, total brain volume, hippocampal volume and AD n…
View article: RELIGIOSITY, RELIGIOUS BELIEFS, AND COGNITIVE STATUS AMONG BLACK AND WHITE MEN WITH SIMILAR INCOMES
RELIGIOSITY, RELIGIOUS BELIEFS, AND COGNITIVE STATUS AMONG BLACK AND WHITE MEN WITH SIMILAR INCOMES Open
Black men experience multiple stressors linked with cognitive impairment and have higher risks for Alzheimer’s Disease and related dementias than their White peers. Yet, few studies have focused on coping resources. Religious beliefs and i…
View article: Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease
Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease Open
View article: Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for developing Alzheimer’s disease
Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for developing Alzheimer’s disease Open
Alzheimer’s Disease (AD) continues to be a leading cause of death in the US. As the US aging population (ages 65 +) expands, the impact will disproportionately affect vulnerable populations, e.g., Hispanic/Latino population, due to their A…
View article: Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release Open
A major drawback of cytotoxic chemotherapy is the lack of selectivity toward noncancerous cells. The targeted delivery of cytotoxic drugs to tumor cells is a longstanding goal in cancer research. We proposed that covalent inhibitors could …
View article: Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US
Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US Open
Importance Understanding how socioeconomic factors are associated with cognitive aging is important for addressing health disparities in Alzheimer disease. Objective To examine the association of neighborhood disadvantage with cognition am…
View article: DNA Methylation in Risk for Cognitive Impairment and Type 2 Diabetes in a Mexican American Cohort
DNA Methylation in Risk for Cognitive Impairment and Type 2 Diabetes in a Mexican American Cohort Open
Background Alzheimer’s disease (AD) and type 2 diabetes (T2D) are among the leading causes of mortality among the growing aging Mexican American population (≥ 65 years old) in the US (Vega et al. 2017). In comparison to their non‐Hispanic …
View article: UPS of the CNS: Longitudinal profiling of mitochondrial DNA in neuronal‐enriched packages from plasma of individuals with cognitive decline
UPS of the CNS: Longitudinal profiling of mitochondrial DNA in neuronal‐enriched packages from plasma of individuals with cognitive decline Open
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder that disproportionately burdens Mexican Americans (MAs) due to a combination of population‐specific environmental exposures and genetic risk factors. In addition t…
View article: Integrative Blood-Based Characterization of Oxidative Mitochondrial DNA Damage Variants Implicates Mexican Americans' Metabolic Risk for Developing Alzheimer’s Disease
Integrative Blood-Based Characterization of Oxidative Mitochondrial DNA Damage Variants Implicates Mexican Americans' Metabolic Risk for Developing Alzheimer’s Disease Open
Alzheimer’s Disease (AD) continues to be a leading cause of death in the US. As the US aging population (ages 65+) expands, the impact will disproportionately affect vulnerable populations, e.g., Hispanic/Latinx population, due to their AD…
View article: Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort
Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort Open
Background: The aging Mexican American (MA) population is the fastest growing ethnic minority group in the US. MAs have a unique metabolic-related risk for Alzheimer’s disease (AD) and mild cognitive impairment (MCI), compared to non-Hispa…
View article: Occupational Stress in University Academics in Australia and New Zealand
Occupational Stress in University Academics in Australia and New Zealand Open
Occupational stress has increased in higher education academic staff over several decades, and this has been particularly acute in Australia and New Zealand. This scoping review sought to understand the causes and impacts of occupational s…
View article: Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites
Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites Open
Background: Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) among Mexican Americans remains limited. Objective: The aim of this study was to characterize MCI a…
View article: Religious service attendance and mortality among older Black men
Religious service attendance and mortality among older Black men Open
Religious institutions have been responsive to the needs of Black men and other marginalized populations. Religious service attendance is a common practice that has been associated with stress management and extended longevity. The objecti…