Stephanie M. de Boer
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View article: Predicting lymphocyte dose and surviving fraction for VMAT and IMPT treatments with a dynamic lymphocyte flow model for locally advanced cervical cancer
Predicting lymphocyte dose and surviving fraction for VMAT and IMPT treatments with a dynamic lymphocyte flow model for locally advanced cervical cancer Open
Objective. A dynamic model is developed to predict the impact of radiotherapy on circulating lymphocyte counts in women with locally advanced cervical cancer (LACC). This study aims to compare the effects of photon and proton therapy, as w…
View article: Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial
Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial Open
View article: Changes in Bone Marrow Fat Fraction and Immune Cell Counts in Women with Cervical Cancer Treated with Primary Chemoradiotherapy
Changes in Bone Marrow Fat Fraction and Immune Cell Counts in Women with Cervical Cancer Treated with Primary Chemoradiotherapy Open
View article: Margin and robustness settings for a library-of-plans IMPT strategy for locally advanced cervical cancer
Margin and robustness settings for a library-of-plans IMPT strategy for locally advanced cervical cancer Open
Objective. This study aims to determine a margin and robustness setting for treating locally advanced cervical cancer (LACC) with a library-of-plans (LoP) based online-adaptive intensity-modulated proton therapy (IMPT). Approach. We analyz…
View article: Accuracy, repeatability, and reproducibility of water-fat magnetic resonance imaging in a phantom and healthy volunteer
Accuracy, repeatability, and reproducibility of water-fat magnetic resonance imaging in a phantom and healthy volunteer Open
Bone marrow (BM) damage due to chemoradiotherapy can increase BM fat in cervical cancer patients. Water-fat magnetic resonance (MR) scans were performed on a phantom and a healthy female volunteer to validate proton density fat fraction ac…
View article: Author Correction: Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Author Correction: Prediction of recurrence risk in endometrial cancer with multimodal deep learning Open
View article: Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Prediction of recurrence risk in endometrial cancer with multimodal deep learning Open
Predicting distant recurrence of endometrial cancer (EC) is crucial for personalized adjuvant treatment. The current gold standard of combined pathological and molecular profiling is costly, hampering implementation. Here we developed HECT…
View article: Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials
Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials Open
View article: Dosimetric impact of bone marrow sparing for robustly optimized IMPT for locally advanced cervical cancer
Dosimetric impact of bone marrow sparing for robustly optimized IMPT for locally advanced cervical cancer Open
Achieving 1 GyRBE BMS for IMPT is feasible for LACC patients with limited dosimetric impact on other OARs. While further bone marrow dose reduction is possible for some patients, it may increase OAR doses substantially for other…
View article: Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation
Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation Open
Universal tumor screening in endometrial carcinoma (EC) is increasingly adopted to identify individuals at risk of Lynch syndrome (LS). These cases involve mismatch repair-deficient (MMRd) EC without MLH1 promoter hypermethylation (PHM). L…
View article: HECTOR: multimodal deep learning predicts recurrence risk in endometrial cancer
HECTOR: multimodal deep learning predicts recurrence risk in endometrial cancer Open
Predicting distant recurrence of endometrial cancer (EC) is crucial for personalized adjuvant treatment. The current gold standard of combined pathological and molecular profiling is costly, hampering implementation. We developed HECTOR ( …
View article: PR024/#394 Molecular profiling of P53 mutant endometrial cancer reveals distinct subgroups with opportunities for personalized therapeutic approaches
PR024/#394 Molecular profiling of P53 mutant endometrial cancer reveals distinct subgroups with opportunities for personalized therapeutic approaches Open
Introduction Endometrial cancer (EC) can be classified into four molecular subgroups: POLE mutant, MSI/dMMR, non-specific profiles and P53 mutant (P53mut). P53mut EC comprise ~20% of cases and have the worst prognosis. There is an urgent m…
View article: Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, -2 and -3 trials
Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, -2 and -3 trials Open
Background Numerous studies have shown that elderly women with endometrial cancer (EC) have a higher risk of recurrence and cancer-related death. It is, however, unclear whether aging is a causal prognostic factor, or whether other risk fa…
View article: 788P Molecular profiling of p53 mutant endometrial cancer reveals distinct subgroups with opportunities for personalized therapeutic approaches
788P Molecular profiling of p53 mutant endometrial cancer reveals distinct subgroups with opportunities for personalized therapeutic approaches Open
View article: Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer
Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer Open
PURPOSE The molecular classification of endometrial cancer (EC) has proven to have prognostic value and is predictive of response to adjuvant chemotherapy. Here, we investigate its predictive value for response to external beam radiotherap…
View article: The impact of bone marrow sparing on organs at risk dose for cervical cancer: a Pareto front analysis
The impact of bone marrow sparing on organs at risk dose for cervical cancer: a Pareto front analysis Open
Background and purpose To quantify the increase in bladder and rectum dose of a bone marrow sparing (BMS) VMAT strategy for primary treatment of locally advanced cervical cancer (LACC). Materials and methods Twenty patients with stage IB-I…
View article: Bi-objective optimization of organ properties for the simulation of intracavitary brachytherapy applicator placement in cervical cancer
Bi-objective optimization of organ properties for the simulation of intracavitary brachytherapy applicator placement in cervical cancer Open
Validation of deformable image registration techniques is extremely important, but hard, especially when complex deformations or content mismatch are involved. These complex deformations and content mismatch, for example, occur after the p…
View article: Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry
Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry Open
View article: Interpretable deep learning model to predict the molecular classification of endometrial cancer from haematoxylin and eosin-stained whole-slide images: a combined analysis of the PORTEC randomised trials and clinical cohorts
Interpretable deep learning model to predict the molecular classification of endometrial cancer from haematoxylin and eosin-stained whole-slide images: a combined analysis of the PORTEC randomised trials and clinical cohorts Open
View article: 2022-RA-925-ESGO Development of adjuvant treatment decision support tool for endometrial cancer patients by pooled analysis of data from 2000 women included in the PORTEC-1–3 trials and a prospective cohort study
2022-RA-925-ESGO Development of adjuvant treatment decision support tool for endometrial cancer patients by pooled analysis of data from 2000 women included in the PORTEC-1–3 trials and a prospective cohort study Open
View article: 2022-RA-825-ESGO The impact of age on prognosis in women with endometrial cancer: a pooled analysis of the PORTEC-1, -2 and -3 randomised trials
2022-RA-825-ESGO The impact of age on prognosis in women with endometrial cancer: a pooled analysis of the PORTEC-1, -2 and -3 randomised trials Open
View article: 2022-RA-568-ESGO Prognostic Relevance of FIGO grading is Limited to NSMP Endometrial Cancers
2022-RA-568-ESGO Prognostic Relevance of FIGO grading is Limited to NSMP Endometrial Cancers Open
View article: 2022-RA-648-ESGO Interpretable deep learning provides clues for prognostic refinement of the molecular endometrial cancer classification
2022-RA-648-ESGO Interpretable deep learning provides clues for prognostic refinement of the molecular endometrial cancer classification Open
View article: 2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other than <i>MLH1</i> promoter hypermethylation
2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other than <i>MLH1</i> promoter hypermethylation Open
Introduction/Background The vast majority of mismatch repair-deficient (MMRd) endometrial carcinomas (EC) are due MLH1 promoter hypermethylation. Here, we aimed to investigate the prevalence, prognosis and underlying causes (includi…
View article: Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry
Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry Open
Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It is unclear whether adding hormone receptor expression, L1CAM expression or CTNNB1 status yields prognostic refinement.…
View article: p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial Open
View article: Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients Open
View article: Interpretable Deep Learning Predicts the Molecular Endometrial Cancer Classification from H&E Images: A Combined Analysis of the Portec Randomized Clinical Trials
Interpretable Deep Learning Predicts the Molecular Endometrial Cancer Classification from H&E Images: A Combined Analysis of the Portec Randomized Clinical Trials Open
View article: PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System
PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System Open
External beam radiation therapy (EBRT) with concurrent chemotherapy followed by brachytherapy is a very effective treatment for locally advanced cervical cancer (LACC). However, treatment-related toxicity is common and reduces the patient’…
View article: Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy
Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy Open