Stephanie M. LaVergne
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View article: Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19
Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 Open
Post-Acute Sequelae of COVID-19 (PASC), or "long COVID," describes persistent symptoms following recovery from SARS-CoV-2 infection. Early identification of circulating biomarkers predictive of PASC is critical for prognosis and therapeuti…
View article: Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers
Persistent CD8+ T cell proliferation and activation in COVID-19 adult survivors with post-acute sequelae: a longitudinal, observational cohort study of persistent symptoms and T cell markers Open
Introduction Post-acute sequelae of COVID-19 affects the quality of life of many COVID-19 survivors, yet the etiology of post-acute sequelae of COVID-19 remains unknown. We aimed to determine if persistent inflammation and ongoing T-cell a…
View article: Procalcitonin levels and antibiotic use associations with COVID-19 disease severity in hospitalized adults and the potential for an increase in antibiotic resistance: a cross-sectional clinical and public health analysis
Procalcitonin levels and antibiotic use associations with COVID-19 disease severity in hospitalized adults and the potential for an increase in antibiotic resistance: a cross-sectional clinical and public health analysis Open
Background: Elevated procalcitonin (PCT) levels guide clinicians in antibiotic use for suspected bacterial infections and subsequent need for antimicrobial therapy. Our aim was to ascertain the usefulness of this laboratory marker in patie…
View article: Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado Open
Vitamin D deficiency is common in the United States and leads to altered immune function, including T cell and macrophage activity that may impact responses to SARS-CoV-2 infection. This study investigated 131 adults with a history of a po…
View article: Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors
Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors Open
Introduction Lassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear. Methods We investigated Lassa virus specific CD8 …
View article: Relationships between plasma fatty acids in adults with mild, moderate, or severe COVID-19 and the development of post-acute sequelae
Relationships between plasma fatty acids in adults with mild, moderate, or severe COVID-19 and the development of post-acute sequelae Open
Background SARS-CoV-2 has infected millions across the globe. Many individuals are left with persistent symptoms, termed post-acute sequelae of COVID-19 (PASC), for months after infection. Hyperinflammation in the acute and convalescent st…
View article: Quality of Life (QoL) Is Reduced in Those with Severe COVID-19 Disease, Post-Acute Sequelae of COVID-19, and Hospitalization in United States Adults from Northern Colorado
Quality of Life (QoL) Is Reduced in Those with Severe COVID-19 Disease, Post-Acute Sequelae of COVID-19, and Hospitalization in United States Adults from Northern Colorado Open
The longitudinal quality of life (QoL) of COVID-19 survivors, especially those with post-acute sequelae (PASC) is not well described. We evaluated QoL in our COVID-19 survivor cohort over 6 months using the RAND SF-36 survey. From July 202…
View article: A Longitudinal SARS-CoV-2 Biorepository for COVID-19 Survivors with and without Post-Acute Sequelae
A Longitudinal SARS-CoV-2 Biorepository for COVID-19 Survivors with and without Post-Acute Sequelae Open
BackgroundSARS-CoV-2 has swept across the globe, causing millions of deaths worldwide. Though most survive, many experience symptoms of COVID-19 for months after acute infection. Successful prevention and treatment of acute COVID-19 infect…
View article: Ebola-Specific CD8+ and CD4+ T-Cell Responses in Sierra Leonean Ebola Virus Survivors With or Without Post-Ebola Sequelae
Ebola-Specific CD8+ and CD4+ T-Cell Responses in Sierra Leonean Ebola Virus Survivors With or Without Post-Ebola Sequelae Open
Background Ebola virus (EBOV) disease has killed thousands of West and Central Africans over the past several decades. Many who survive the acute disease later experience post-Ebola syndrome, a constellation of symptoms whose causative pat…
View article: Impact of Latent Tuberculosis Infection on Neurocognitive Functioning and Inflammation in HIV-Infected and Uninfected South Indians
Impact of Latent Tuberculosis Infection on Neurocognitive Functioning and Inflammation in HIV-Infected and Uninfected South Indians Open
Background: HIV-associated neurocognitive disorder persists in some people living with HIV despite optimal antiretroviral therapy. Latent tuberculosis infection (LTBI) may cause systemic inflammation and immune activation that may impair b…
View article: A unique variant of lymphocytic choriomeningitis virus that induces pheromone binding protein MUP: Critical role for CTL
A unique variant of lymphocytic choriomeningitis virus that induces pheromone binding protein MUP: Critical role for CTL Open
Significance Pheromones play essential roles in host communications and sexual attraction, and thus regulate adaptive behavior. Here we present the discovery and characterization of the first known virus, a variant of lymphocytic choriomen…
View article: Myroides injenensis Bacteremia and Severe Cellulitis
Myroides injenensis Bacteremia and Severe Cellulitis Open
Myroides spp. are environmental bacterial organisms that rarely cause disease in humans. Myroides spp. infections are infrequently reported in the literature, and Myroides injenensis infections are quite uncommon. Myroides spp. usually inf…
View article: Pasteurella multocida line infection: a case report and review of literature
Pasteurella multocida line infection: a case report and review of literature Open
Pasteurella Multocida bacteremia in the presence of a long-term central venous catheter is potentially curable using 2 weeks of intravenous antibiotics and line retention. Further data regarding outcomes of treatment in this setting are re…
View article: Phage Therapy for a Multidrug-Resistant Acinetobacter baumannii Craniectomy Site Infection
Phage Therapy for a Multidrug-Resistant Acinetobacter baumannii Craniectomy Site Infection Open
In the era of antibiotic resistance, alternative treatment options for multidrug-resistant bacterial infections are being explored. We present a case of multidrug-resistant Acinetobacter baumannii infection treated with bacteriophages. Cli…