Stephanie Pfaender
YOU?
Author Swipe
View article: From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism
From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism Open
Given the recurring threat of coronavirus outbreaks, understanding the specificity of coronaviruses in terms of their host, tissue, and cell tropism is crucial. This review consolidates and critically assesses the current literature on the…
View article: JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein
JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein Open
View article: Plasma proteomics identifies molecular subtypes in sepsis
Plasma proteomics identifies molecular subtypes in sepsis Open
View article: Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators
Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators Open
Autophagy is a cellular degradation and recycling process important for maintaining cellular health and function. It is constitutively active at a low level in eukaryotic cells and can be induced by conditions of cellular stress, such as n…
View article: Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants
Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants Open
Mycophenolic acid (MPA) is commonly used in immunosuppressive regimens following solid organ transplantation. We demonstrate that MPA treatment reproducibly inhibits the replication of a range of viruses, including severe respiratory syndr…
View article: Plasma proteomics identifies molecular subtypes in sepsis
Plasma proteomics identifies molecular subtypes in sepsis Open
Background The heterogeneity of sepsis represents a significant challenge to the development of personalized sepsis therapies. Sepsis subtyping has therefore emerged as an important approach to this problem, but its impact on clinical prac…
View article: The protein interaction of mitochondrial transcription factors A and B2 is associated with 30-day survival in critical COVID-19
The protein interaction of mitochondrial transcription factors A and B2 is associated with 30-day survival in critical COVID-19 Open
Introduction Repair of mitochondrial damage seems pivotal for clinical recovery and determining outcome in patients with critical COVID-19. However, reliable biomarkers for non-invasively assessing mitochondrial repair in peripheral blood …
View article: Ultra‐Shallow Flat Heat Waves on Low Thermal Conductivity Flexible Polyimide Substrate for Millisecond Thermal Analysis of Materials and Bioelectronic Applications
Ultra‐Shallow Flat Heat Waves on Low Thermal Conductivity Flexible Polyimide Substrate for Millisecond Thermal Analysis of Materials and Bioelectronic Applications Open
Transient thermal analysis has a wide range of applications across scientific disciplines including physics, material science, and biology. While this analysis is typically straightforward when measurement is taken over minutes or seconds,…
View article: Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases
Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases Open
Background Hypersensitivity to odorants like perfumes can induce or promote asthma with non-type 2 inflammation for which therapeutic options are limited. Cell death of primary bronchial epithelial cells (PBECs) and the release of the pro-…
View article: The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle
The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle Open
The replication organelle of hepatitis C virus (HCV), called membranous web, is derived from the endoplasmic reticulum (ER) and mainly comprises double membrane vesicles (DMVs) that concentrate the viral replication complexes. It also tigh…
View article: <scp>MicroRNAs</scp> modulate <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection of primary human hepatocytes by regulating the entry factors <scp>ACE2</scp> and <scp>TMPRSS2</scp>
<span>MicroRNAs</span> modulate <span>SARS</span>‐<span>CoV</span>‐2 infection of primary human hepatocytes by regulating the entry factors <span>ACE2</span> and <span>TMPRSS2</span> Open
Background and Aims Severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) preferentially infects the respiratory tract; however, several studies have implicated a multi‐organ involvement. Hepatic dysfunctions caused by SARS‐CoV‐2 infe…
View article: TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution
TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution Open
The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing cells, although how increased entry impacts downstream viral and host proces…
View article: Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis
Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis Open
Background Sepsis, a life-threatening condition caused by the dysregulated host response to infection, is a major global health concern. Understanding the impact of viral or bacterial pathogens in sepsis is crucial for improving patient ou…
View article: Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells Open
ORs might be promising drug target candidates for lung diseases with non-type 2 inflammation. Their stimulation might reduce inflammation or prevent tissue remodeling by promoting wound healing.
View article: Host determinants and responses underlying SARS-CoV-2 liver tropism
Host determinants and responses underlying SARS-CoV-2 liver tropism Open
Hepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection ou…
View article: Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents
Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents Open
Purpose In contrast to adults, immune protection against SARS-CoV-2 in children and adolescents with natural or hybrid immunity is still poorly understood. The aim of this study was to analyze different immune compartments in different age…
View article: Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses
Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses Open
View article: Increased <scp>SARS‐CoV</scp> ‐2 reactive low avidity T cells producing inflammatory cytokines in pediatric post‐acute <scp>COVID</scp> ‐19 sequelae ( <scp>PASC</scp> )
Increased <span>SARS‐CoV</span> ‐2 reactive low avidity T cells producing inflammatory cytokines in pediatric post‐acute <span>COVID</span> ‐19 sequelae ( <span>PASC</span> ) Open
Background A proportion of the convalescent SARS‐CoV‐2 pediatric population presents nonspecific symptoms, mental health problems, and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) an…
View article: Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents
Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents Open
View article: Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents
Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents Open
Purpose The immune protection in children and adolescents with natural or hybrid immunity (vaccination & infection) against SARS-CoV-2 remains an understudied field. Aim of this study was to analyze different immune compartments in differe…
View article: Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC)
Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC) Open
Background: A proportion of the convalescent SARS-CoV-2 pediatric population presents nonspecific symptoms, mental health problems and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) an…
View article: Fading SARS-CoV-2 humoral VOC cross-reactivity versus sustained cellular immunity in convalescent children and adolescents
Fading SARS-CoV-2 humoral VOC cross-reactivity versus sustained cellular immunity in convalescent children and adolescents Open
Cross-reactive cellular and humoral immunity can substantially contribute to antiviral defense against SARS-CoV-2 variants of concern (VOC). While the adult SARS-CoV-2 cellular and humoral immunity and its cross-recognition potential again…
View article: Longitudinal data on humoral response and neutralizing antibodies against SARS-CoV-2 Omicron BA.1 and subvariants BA.4/5 and BQ.1.1 after COVID-19 vaccination in cancer patients
Longitudinal data on humoral response and neutralizing antibodies against SARS-CoV-2 Omicron BA.1 and subvariants BA.4/5 and BQ.1.1 after COVID-19 vaccination in cancer patients Open
Purpose The SARS-CoV-2 Omicron variant of concern (VOC) and subvariants like BQ.1.1 demonstrate immune evasive potential. Little is known about the efficacy of booster vaccinations regarding this VOC and subvariants in cancer patients. Thi…
View article: Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19
Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19 Open
The role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19 (PASC) is not well explored, although a growing population of convalescent COVID-19 patients with manifestation of PASC is observed. We analyzed the SARS-…
View article: Fading SARS-CoV-2 humoral and sustained cellular immunity in convalescent children and adolescents
Fading SARS-CoV-2 humoral and sustained cellular immunity in convalescent children and adolescents Open
Cross-reactive cellular and humoral immunity can substantially contribute to antiviral defense against SARS-CoV-2 variants of concern (VOC). While the adult SARS-CoV-2 cellular and humoral immunity and its cross-recognition potential again…
View article: Immunogenicity of Bivalent Omicron BA.4/5–Adapted Vaccine in Hemodialysis Patients
Immunogenicity of Bivalent Omicron BA.4/5–Adapted Vaccine in Hemodialysis Patients Open
View article: Significant Fade of Neutralizing Antibodies and Stable Cellular Immunity in 4 Times COVID-19 Vaccinated Noninfected Compared to COVID-19 Convalescent and 3 Times Vaccinated Hemodialysis Patients
Significant Fade of Neutralizing Antibodies and Stable Cellular Immunity in 4 Times COVID-19 Vaccinated Noninfected Compared to COVID-19 Convalescent and 3 Times Vaccinated Hemodialysis Patients Open
View article: Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome
Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome Open
The role of autoimmunity in post-acute sequelae of COVID-19 (PASC) is not well explored, although clinicians observe a growing population of convalescent COVID-19 patients with manifestation of post-acute sequelae of COVID-19. We analyzed …
View article: Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV
Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV Open
Despite the development of vaccines, which protect healthy people from severe and life-threatening Covid-19, the immunological responses of people with secondary immunodeficiencies to these vaccines remain incompletely understood. Here, we…
View article: SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity
SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity Open