Explanipedia

Sustainability in Critical Care units: an opinion paper from the SFAR (French Society of anaesthesia and Critical Care) Sustainability and Critical Care Committees Open

Stéphanie Pons, Enora Atchade, Erwan d’Aranda, Fanny Vardon‐Bounes, Florence Lallemant , et al. · 2025

The ecodesign of healthcare is an empowering approach that integrates environmental considerations throughout the entire life cycle of care. Its conciliation to both care quality and patient safety in critical care units is possible and es…

Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study Open

Erwan d’Aranda, Stéphanie Pons, Jonathan Chelly, Enora Atchade, Laure Bonnet , et al. · 2025

ClinicalTrials.gov: NCT05553054 . September 23, 2022.

Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study Open

Camille Windsor, Adrien Joseph, Stéphanie Pons, Djamel Mokart, Frédéric Pène , et al. · 2024

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety Open

Tinaïg Le Borgne, Claire Nguyen, E. Vicq, Joachim Jehl, Clément Solié , et al. · 2024

SUMMARY Nicotine activates ventral tegmental area (VTA) dopaminergic (DA) neurons projecting to the nucleus accumbens (NAc) to drive its reinforcing effects. Simultaneously, it inhibits those projecting to the amygdala (Amg) to mediate anx…

Prospective multi-center evaluation of the incidence of unplanned extubation and its outcomes in French intensive care units. The Safe-ICU study Open

Jérémie Guillemin, Benjamin Rieu, Olivier Huet, Léonie Villeret, Stéphanie Pons , et al. · 2024

PB1545 Antiphospholipid Antibodies Profile in Women with Periodontal Disease Open

Patricia Casais, Stéphanie Pons, M. Herrera, S. Bonaccorso, V. Monserrat , et al. · 2023

Conclusion(s):This observational study showed that patients in remission from ER-positive breast cancer taking tamoxifen as adjuvant therapy had an altered thrombin generation, depicting a shift towards a hypercoagulable state as well as a…

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies Open

Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Aymé , et al. · 2023

Guidelines for reducing the environmental impact of general anaesthesia Open

Jean-Claude Pauchard, El-Madhi Hafiani, Stéphanie Pons, Laure Bonnet, Delphine Cabelguenne , et al. · 2023

Prospective multi-centre evaluation of the incidence of unplanned extubation and its outcomes in intensive care units. The Safe-ICU study Open

Jérémie Guillemin, Benjamin Rieu, Olivier Huet, Léonie Villeret, Stéphanie Pons , et al. · 2023

Background: The lack of a clear definition and strong methodology has led to differing results in terms of unplanned extubation (UE) epidemiology and outcomes. We aimed to determine the UE incidence and clinical significance of both accide…

A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates Open

Stéphanie Pons, Eric Frapy, Youssouf Sérémé, Charlotte Gaultier, François Lebreton , et al. · 2023

ANR Seq-N-Vaq, Charles Hood Foundation, Hearst Foundation, and Groupe Pasteur Mutualité.

An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies Open

Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Aymé , et al. · 2023

The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest to design ligands for the treatment of neurological and psychiatric disorders. To develop a novel…

A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates Open

Stéphanie Pons, Eric Frapy, Youssouf Sérémé, Charlotte Gaultier, François Lebreton , et al. · 2022

Background Worldwide, Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but full understanding of the pathogenesis of this disease is not yet achieved. Moreover, to date, no vaccine is available against …

How Protective are Antibodies to SARS-CoV-2, the Main Weapon of the B-Cell Response? Open

Stéphanie Pons, Fabrice Uhel, Eric Frapy, Youssouf Sérémé, Lara Zafrani , et al. · 2022

Récepteur nicotinique de l’acétylcholine et bronchopneumopathie chronique obstructive Open

Valérian Dormoy, Stéphanie Pons, Philippe Gosset, Uwe Maskos · 2022

International audience

One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial Open

Florian Blanchard, Thomas Godet, Stéphanie Pons, Natacha Kapandji, Matthieu Jabaudon , et al. · 2022

Background Acute respiratory distress syndrome (ARDS) has different phenotypes and distinct short-term outcomes. Patients with non-focal ARDS have a higher short-term mortality than focal ones. The aim of this study was to assess the impac…

Omicron Variant in the Critical Care Units of the Paris Metropolitan Area: The Reality Research Group Open

Antoine Vieillard‐Baron, Rémi Flicoteaux, Maud Salmona, Appoline Chariot, Bertrand de Maupeou D’ableiges , et al. · 2022

International audience

Endothelial Cells Activated by Extracellular Histones Promote Foxp3+ Suppressive Treg Cells In Vitro Open

Marine Arnaud, Jordane Demonchy, Eden Arrii, Marta Luperto, Julien Lion , et al. · 2022

Histones are widely recognized as pro-inflammatory mediators upon their release from the nucleus into the extracellular space. However, their impact on endothelial cell immunogenicity is unknown. Endothelial cells, Human Microvascular Endo…

EPIDEMIOLOGICAL CHARACTERISTICS AND SEVERITY OF OMICRON VARIANT CASES IN THE APHP CRITICAL CARE UNITS Open

Antoine Vieillard‐Baron, Rémi Flicoteaux, Maud Salmona, Djillali Annane, S. Ayed , et al. · 2022

Importance Information about the severity of Omicron is scarce. Objective To report the respective risk of ICU admission in patients hospitalized with Delta and Omicron variants and to compare the characteristics and disease severity of cr…

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions Open

Julie Routhier, Stéphanie Pons, Mohamed Lamine Freidja, Véronique Dalstein, Jérôme Cutrona , et al. · 2021

Immunomodulation of endothelial cells induced by macrolide therapy in a model of septic stimulation Open

Stéphanie Pons, Eden Arrii, Marine Arnaud, Maud Loiselle, Juliette Ferry , et al. · 2021

Objectives Sepsis is defined as the host's inflammatory response to a life‐threatening infection. The endothelium is implicated in immunoregulation during sepsis. Macrolides have been proposed to display immunomodulatory properties. The go…

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects Open

David M. Smadja, Steven J. Mentzer, Michaëla Fontenay, Michael Laffan, Maximilian Ackermann , et al. · 2021

Unexpected Lessons from the Coronavirus Disease 2019 Lockdowns in France: Low Impact of School Opening on Common Communicable Pediatric Airborne Diseases Open

David Skurnik, Alexis Rybak, David Dawei Yang, Stéphanie Pons, Romain Guedj , et al. · 2020

International audience

Correction to: Assessment of Bacterial Colonization of Intracranial Pressure Transducers: A Prospective Study Open

R Mounier, Natacha Kapandji, Guillaume Gricourt, David Lobo, Christophe Rodriguez , et al. · 2020

Assessment of Bacterial Colonization of Intracranial Pressure Transducers: A Prospective Study Open

R Mounier, Natacha Kapandji, Guillaume Gricourt, David Lobo, Christophe Rodriguez , et al. · 2020

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection Open

Stéphanie Pons, Sofiane Fodil, Élie Azoulay, Lara Zafrani · 2020

Dernières avancées thérapeutiques dans la prise en charge du syndrome de lyse tumorale Open

Lara Zafrani, Marine Arnaud, Stéphanie Pons · 2019

Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation Open

Stéphanie Pons, Romain Sonneville, Lila Bouadma, Lenka Styfalova, Stéphane Ruckly , et al. · 2019

Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae Open

David Skurnik, Damien Roux, Stéphanie Pons, Thomas Guillard, Xi Lü , et al. · 2016

Our findings suggest antibodies to PNAG may provide extended-spectrum antibacterial protective activity.

Emergence of Antimicrobial-Resistant<i>Escherichia coli</i>of Animal Origin Spreading in Humans Open

David Skurnik, Olivier Clermont, Thomas Guillard, Adrien Launay, Olga Danilchanka , et al. · 2015

In the context of the great concern about the impact of human activities on the environment, we studied 403 commensal Escherichia coli/Escherichia clade strains isolated from several animal and human populations that have variable contacts…

Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix Open

Damien Roux, Colette Cywes‐Bentley, Chengcui Zhang, Stéphanie Pons, M. A. Konkol , et al. · 2015

Bacillus subtilis is intensively studied as a model organism for the development of bacterial biofilms or pellicles. A key component is currently undefined exopolysaccharides produced from proteins encoded by genes within the eps locus. Wi…

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