Explanipedia

Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case — New York, March 9–October 11, 2022 Open

A. Blythe Ryerson, Daniel J. Lang, Mohammed Alazawi, Milagros Neyra, Dustin Hill , et al. · 2022

In July 2022, a case of paralytic poliomyelitis resulting from infection with vaccine-derived poliovirus (VDPV) type 2 (VDPV2)^§ was confirmed in an unvaccinated adult resident of Rockland County, New York (1). As of August 10, 2…

COVID-19-Associated Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, January 2021 to April 2022 Open

Fiona P. Havers, Huong Pham, Christopher A. Taylor, Michael Whitaker, Kadam Patel , et al. · 2022

Importance Understanding risk factors for hospitalization in vaccinated persons and the association of COVID-19 vaccines with hospitalization rates is critical for public health efforts to control COVID-19. Objective To determine character…

Analysis of the initial lot of the CDC 2019-Novel Coronavirus (2019-nCoV) real-time RT-PCR diagnostic panel Open

Justin S. Lee, Jason Goldstein, J Moon, Owen Herzegh, Dennis A. Bagarozzi , et al. · 2021

At the start of the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC) designed, manufactured, and distributed the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel for SARS-CoV-2 detection. The …

Predictors at Admission of Mechanical Ventilation and Death in an Observational Cohort of Adults Hospitalized With Coronavirus Disease 2019 Open

Brendan R. Jackson, Jeremy A.W. Gold, Pavithra Natarajan, John Rossow, Robyn Neblett Fanfair , et al. · 2020

Background Coronavirus disease (COVID-19) can cause severe illness and death. Predictors of poor outcome collected on hospital admission may inform clinical and public health decisions. Methods We conducted a retrospective observational co…

Characteristics and Clinical Outcomes of Adult Patients Hospitalized with COVID-19 — Georgia, March 2020 Open

Jeremy A.W. Gold, Karen K. Wong, Christine M. Szablewski, Priti R. Patel, John Rossow , et al. · 2020

SARS-CoV-2, the novel coronavirus that causes coronavirus disease 2019 (COVID-19), was first detected in the United States during January 2020 (1). Since then, >980,000 cases have been reported in the United States, including >55,000 assoc…

Geographic Differences in COVID-19 Cases, Deaths, and Incidence — United States, February 12–April 7, 2020 Open

Stephanie R. Bialek, Virginia B. Bowen, Nancy A. Chow, Aaron T. Curns, Ryan Gierke , et al. · 2020

Community transmission of coronavirus disease 2019 (COVID-19) was first detected in the United States in February 2020. By mid-March, all 50 states, the District of Columbia (DC), New York City (NYC), and four U.S. territories had reported…

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020 Open

Stephanie R. Bialek, Ryan Gierke, Michelle M. Hughes, Lucy A. McNamara, Tamara Pilishvili , et al. · 2020

As of April 2, 2020, the coronavirus disease 2019 (COVID-19) pandemic has resulted in >890,000 cases and >45,000 deaths worldwide, including 239,279 cases and 5,443 deaths in the United States (1,2). In the United States, 22% of the popula…

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020 Open

Stephanie R. Bialek, Ellen O. Boundy, Virginia B. Bowen, Nancy A. Chow, Amanda Cohn , et al. · 2020

Globally, approximately 170,000 confirmed cases of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) have been reported, including an estimated 7,000 deaths in approximately 150 countries (1). On March 1…

Congenital Chagas Disease in the United States: The Effect of Commercially Priced Benznidazole on Costs and Benefits of Maternal Screening Open

Victoria Perez-Zetune, Stephanie R. Bialek, Susan P. Montgomery, Eileen Stillwaggon · 2020

Chagas disease, caused by Trypanosoma cruzi , is transmitted by insect vectors, and through transfusions, transplants, insect feces in food, and mother to child during gestation. An estimated 30% of infected persons will develop lifelong, …

Evaluation and Management of Congenital Chagas Disease in the United States Open

Morven S. Edwards, Kelly K. Stimpert, Stephanie R. Bialek, Susan P. Montgomery · 2019

Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that …

Eliminating Neglected Tropical Diseases in Urban Areas: A Review of Challenges, Strategies and Research Directions for Successful Mass Drug Administration Open

Alayne M. Adams, Myriam Vučković, Eleanor M. Birch, Tara A. Brant, Stephanie R. Bialek , et al. · 2018

Since 1950, the global urban population grew from 746 million to almost 4 billion and is expected to reach 6.4 billion by mid-century. Almost 90% of this increase will take place in Asia and Africa and disproportionately in urban slums. In…

Congenital Chagas Disease in the United States: Cost Savings through Maternal Screening Open

Eileen Stillwaggon, Victoria Perez-Zetune, Stephanie R. Bialek, Susan P. Montgomery · 2018

Chagas disease, caused by Trypanosoma cruzi , is transmitted by insect vectors through transfusions, transplants, insect feces in food, and from mother to child during gestation. Congenital infection could perpetuate Chagas disease indefin…

Hearing Trajectory in Children with Congenital Cytomegalovirus Infection Open

Tatiana M. Lanzieri, Winnie Chung, Jessica Leung, A. Chantal Caviness, Jason Baumgardner , et al. · 2018

Objectives To compare hearing trajectories among children with symptomatic and asymptomatic congenital cytomegalovirus infection through age 18 years and to identify brain abnormalities associated with sensorineural hearing loss (SNHL) in …

Urinary Cytomegalovirus Shedding in the United States: The National Health and Nutrition Examination Surveys, 1999–2004 Open

Minal M. Amin, Stephanie R. Bialek, Sheila C. Dollard, Chengbin Wang · 2018

Urinary CMV shedding and viral loads decreased dramatically with age, likely reflecting higher rates of primary CMV infection and longer duration of shedding in younger individuals. The findings demonstrate that children aged 6-11 years co…

Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection Open

Adriana Lopez, Tatiana M. Lanzieri, Angelika H. Claussen, Sherry Vinson, Marie Turcich , et al. · 2017

OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth com…

Hearing Loss in Children With Asymptomatic Congenital Cytomegalovirus Infection Open

Tatiana M. Lanzieri, Winnie Chung, Marily Flores, Peggy Blum, A. Chantal Caviness , et al. · 2017

OBJECTIVES: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth c…

Cohort study on maternal cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China Open

Shiwen Wang, Tongzhan Wang, Wenqiang Zhang, Xiaolin Liu, Xiaofang Wang , et al. · 2017

Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence and burden of congenital CMV infection are not well defined in China.…

What Do We Know About Chagas Disease in the United States? Open

Susan P. Montgomery, Monica E. Parise, Ellen M. Dotson, Stephanie R. Bialek · 2016

Chagas disease, caused by the parasite Trypanosoma cruzi , affects more than 5 million people worldwide leading to serious heart and gastrointestinal disease in a proportion of chronically infected patients. Important modes of transmission…

Influence of parity and sexual history on cytomegalovirus seroprevalence among women aged 20–49 years in the USA Open

Tatiana M. Lanzieri, Deanna Kruszon‐Moran, Manoj Gambhir, Stephanie R. Bialek · 2016

Objective To assess the influence of parity, as a proxy for exposure to children, and sexual history on cytomegalovirus (CMV) seroprevalence. Methods Data were retrospectively analyzed from women aged 20–49 years who were tested for CMV im…

Self-reported herpes zoster, pain, and health care seeking in the Health and Retirement Study: implications for interpretation of health care–based studies Open

Craig M. Hales, Rafael Harpaz, Stephanie R. Bialek · 2016

HRS provides a new platform for studies of HZ, one which allowed us to uncover issues that warrant particular attention when interpreting results of health care-based studies.

Cytomegalovirus IgM Seroprevalence among Women of Reproductive Age in the United States Open

Chengbin Wang, Sheila C. Dollard, Minal M. Amin, Stephanie R. Bialek · 2016

Cytomegalovirus (CMV) IgM indicates recent active CMV infection. CMV IgM seroprevalence is a useful marker for prevalence of transmission. Using data from the National Health and Nutrition Examination Survey (NHANES) III 1988-1994, we pres…

Varicella Vaccine Effectiveness in Preventing Community Transmission in the 2-Dose Era Open

Dana Perella, Chengbin Wang, Rachel Civen, Kendra Viner, Karen Kuguru , et al. · 2016

OBJECTIVES: We examined overall and incremental effectiveness of 2-dose varicella vaccination in preventing community transmission of varicella among children aged 4 to 18 years in 2 active surveillance sites. One-dose varicella vaccine ef…

Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years Open

Hung Fu Tseng, Rafael Harpaz, Yi Luo, Craig M. Hales, Lina S. Sy , et al. · 2016

Understanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for determining vaccine policy. 176 078 members of Kaiser Permanente ≥60 years vaccinated with HZ vaccine and three matched unvaccinated members were included.…

Varicella immunization requirements for US colleges: 2014–2015 academic year Open

Jessica Leung, Mona Marin, Victor Leino, Susan Even, Stephanie R. Bialek · 2016

A small proportion of US colleges have a varicella prematriculation requirement for varicella immunity. College vaccination requirements are an important tool for controlling varicella in these settings.

Risk Factors for Herpes Zoster Among Adults Open

Mona Marin, Rafael Harpaz, John H. Zhang, Peter C. Wollan, Stephanie R. Bialek , et al. · 2016

Background. The causes of varicella-zoster virus reactivation and herpes zoster (HZ) are largely unknown. We assessed potential risk factors for HZ, the data for which cannot be obtained from the medical sector. Methods. We conducted a mat…

Zoster Vaccine and the Risk of Postherpetic Neuralgia in Patients Who Developed Herpes Zoster Despite Having Received the Zoster Vaccine Open

Hung Fu Tseng, Bruno Lewin, Craig M. Hales, Lina S. Sy, Rafael Harpaz , et al. · 2015

Among persons experiencing HZ, prior HZ vaccination is associated with a lower risk of PHN in women but not in men. This sex-related difference may reflect differences in healthcare-seeking patterns and deserve further investigation.

Herpes zoster vaccine effectiveness and manifestations of herpes zoster and associated pain by vaccination status Open

Mona Marin, Barbara P. Yawn, Craig M. Hales, Peter C. Wollan, Stephanie R. Bialek , et al. · 2015

Options for managing herpes zoster (HZ)-related pain and complications have limited effectiveness, making HZ prevention through vaccination an important strategy. Limited data are available on HZ vaccine effectiveness against confirmed HZ …

Trends in varicella mortality in the United States: Data from vital statistics and the national surveillance system Open

Jessica Leung, Stephanie R. Bialek, Mona Marin · 2015

This manuscript describes trends in US varicella mortality using national vital statistics system data for 2008-2011, the first years of the routine 2-dose varicella vaccination program, and characteristics of varicella deaths reported to …

Risk Factors for Herpes Zoster Open

Mona Marin, Rafael Harpaz, John H. Zhang, Peter C. Wollan, Stephanie R. Bialek , et al. · 2015

Influence of Parity and Sexual History on Cytomegalovirus Seroprevalence Among Women 20–49 Years Old Open

Tatiana M. Lanzieri, Deanna Kruszon-Moran, Stephanie R. Bialek · 2015

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