Stephanie R. Weldon
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View article: Modular evolution and strain-specific partnerships: how <i>Hamiltonella defensa</i> shapes defense and symbiont communities in aphids
Modular evolution and strain-specific partnerships: how <i>Hamiltonella defensa</i> shapes defense and symbiont communities in aphids Open
Insects frequently carry maternally-transmitted endosymbionts that mediate ecological interactions, including resource acquisition and host defense. All pea aphids ( Acyrthosiphon pisum ), for example, carry the obligate nutritional symbio…
View article: Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21
Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21 Open
Repetitive display of the major repeats of the Plasmodium falciparum circumsporozoite protein (PfCSP) is the basis for two WHO-recommended vaccines: RTS,S/AS01 and R21/Matrix-M. Recently, however, the CIS43 monoclonal antibody that prefere…
View article: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization
Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization Open
Current vaccine strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multi-boost immunization regimens. In rhesus macaques, SHIV infection has been observed to rapidly drive the development …
View article: Affinity gaps among B cells in germinal centers drive the selection of MPER precursors
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors Open
Current prophylactic human immunodeficiency virus 1 (HIV-1) vaccine research aims to elicit broadly neutralizing antibodies (bnAbs). Membrane-proximal external region (MPER)-targeting bnAbs, such as 10E8, provide exceptionally broad neutra…
View article: mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies Open
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is ineffici…
View article: mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models Open
Germline-targeting (GT) protein immunogens to induce VRC01-class broadly neutralizing antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise in clinical trials. Here, we preclinically validated a lipid nano…
View article: Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand
Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand Open
Antibodies are produced at high rates to provide immunoprotection, which puts pressure on the B cell translational machinery. Here, we identified a pattern of codon usage conserved across antibody genes. One feature thereof is the hyperuti…
View article: Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice Open
Eliciting broadly neutralizing antibodies (bnAbs) is the core of HIV vaccine design. bnAbs specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest somatic hypermutation, making them attractive vaccination…
View article: Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses Open
View article: The Evolution of Interdependence in a Four-Way Mealybug Symbiosis
The Evolution of Interdependence in a Four-Way Mealybug Symbiosis Open
Mealybugs are insects that maintain intracellular bacterial symbionts to supplement their nutrient-poor plant sap diets. Some mealybugs have a single betaproteobacterial endosymbiont, a Candidatus Tremblaya species (hereafter Tremblaya) th…
View article: The evolution of interdependence in a four-way mealybug symbiosis
The evolution of interdependence in a four-way mealybug symbiosis Open
Mealybugs are insects that maintain intracellular bacterial symbionts to supplement their nutrientpoor plant sap diets. Some mealybugs have a single betaproteobacterial endosymbiont, a Candidatus Tremblaya species (hereafter Tremblaya ) th…
View article: Prokka-Sodalis_endolongispinus
Prokka-Sodalis_endolongispinus Open
Genome sequence and annotation (Prokka) of Sodalis endolongispinus, endosymbiont of P. longispinus, the long-tailed mealybug
View article: bioassay data from: More is not always better: coinfections with defensive symbionts generate highly variable outcomes.
bioassay data from: More is not always better: coinfections with defensive symbionts generate highly variable outcomes. Open
Weldon SR, Russell JA, Oliver KM. 2020. More is not always better: coinfections. with defensive symbionts generate highlyvariable outcomes. Appl Environ Microbiol 86:e02537-19. https://doi.org/10.1128/AEM .02537-19.Enemy challenge and comp…
View article: More Is Not Always Better: Coinfections with Defensive Symbionts Generate Highly Variable Outcomes
More Is Not Always Better: Coinfections with Defensive Symbionts Generate Highly Variable Outcomes Open
The hyperdiverse arthropods often harbor maternally transmitted bacteria that protect against natural enemies. In many species, low-diversity communities of heritable symbionts are common, providing opportunities for cooperation and confli…