Stephanie S. Dawes
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View article: Feedback regulation of iron-sulfur cluster biogenesis
Feedback regulation of iron-sulfur cluster biogenesis Open
Iron-sulfur (Fe-S) clusters are ubiquitous cofactors in biological systems. Given their central role in bacterial metabolism and pathogenesis, the biogenesis of Fe-S clusters is tightly controlled. We reveal a feedback regulatory mechanism…
View article: Allosteric inhibition of <i>Staphylococcus aureus</i> MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway
Allosteric inhibition of <i>Staphylococcus aureus</i> MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway Open
Menaquinones (MKs) are electron carriers in bacterial respiratory chains. In Staphylococcus aureus (Sau), MKs are essential for aerobic and anaerobic respiration. As MKs are redox-active, their biosynthesis likely requires tight regulation…
View article: RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria
RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria Open
Multidrug-resistant (MDR) tuberculosis (TB) is defined by the resistance of Mycobacterium tuberculosis , the causative organism, to the first-line antibiotics rifampicin and isoniazid. Mitigating or reversing resistance to these drugs offe…
View article: Allosteric inhibition of <i>Staphylococcus aureus</i> MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway
Allosteric inhibition of <i>Staphylococcus aureus</i> MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway Open
Summary Menaquinones (MKs) are electron carriers in bacterial respiratory chains. In Staphylococcus aureus ( Sau ), MKs are essential for aerobic and anaerobic respiration. As MKs are redox-active, their biosynthesis likely requires tight …
View article: Correction for Kipkorir et al., “ <i>De Novo</i> Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in <i>Mycobacterium smegmatis</i> ”
Correction for Kipkorir et al., “ <i>De Novo</i> Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in <i>Mycobacterium smegmatis</i> ” Open
Volume 203, no. 7, e00620-20, 2021, https://doi.org/10.1128/JB.00620-20. Page 1: This article was published on 8 March 2021 with Stephanie S. Dawes missing from the byline. The byline was updated in the version posted on 21 January 2022. T…
View article: RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria
RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria Open
Multidrug resistant (MDR) tuberculosis (TB) is defined by the resistance of Mycobacterium tuberculosis , the causative organism, to the first-line antibiotics rifampicin and isoniazid. Mitigating or reversing resistance to these drugs offe…
View article: <i>De Novo</i> Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis
<i>De Novo</i> Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis Open
Alterations in cobalamin-dependent metabolism have marked the evolution of Mycobacterium tuberculosis into a human pathogen. However, the role(s) of cobalamin in mycobacterial physiology remain poorly understood.
View article: Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis
Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis Open
Menaquinone (vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including the human pathogen Mycobacterium tuberculosis (Mtb). Although menaquinone levels are known to be tightly linked to th…
View article: Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen
Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen Open
Menaquinone (Vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including Mycobacterium tuberculosis ( Mtb ). Although menaquinone levels are known to be tightly linked to the redox/energy st…
View article: Does the source of referral affect outcomes for paediatric testicular torsion?
Does the source of referral affect outcomes for paediatric testicular torsion? Open
Introduction This single centre study retrospectively analysed the intraoperative findings relative to source of referral for emergency scrotal explorations performed in a tertiary level paediatric surgery department. Methods All patients …
View article: Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome <i>c</i> Oxidase in <i>Mycobacterium tuberculosis</i> ”
Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome <i>c</i> Oxidase in <i>Mycobacterium tuberculosis</i> ” Open
Volume 58, no. 11, p. 6962–6965, 2014, [https://doi.org/10.1128/AAC.03486-14][1]. Page 6963, left column, second paragraph: the following text in lines 5 to 10 should be deleted. “We deleted this oxidase in H37Rv by replacing a 221-bp MluI…
View article: The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis
The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis Open
Cholesterol can be a major carbon source forMycobacterium tuberculosisduring infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repr…