Stephanie Hoeppener
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View article: Enhanced Efficiency of the Microsomal Prostaglandin E <sub>2</sub> Synthase-1 Inhibitor AGU661 in Human Whole Blood by Encapsulation into PLGA-Based Nanoparticles
Enhanced Efficiency of the Microsomal Prostaglandin E <sub>2</sub> Synthase-1 Inhibitor AGU661 in Human Whole Blood by Encapsulation into PLGA-Based Nanoparticles Open
Microsomal prostaglandin E2 synthase 1 (mPGES-1) is a promising target for treating chronic inflammatory diseases and pain. The novel benzimidazole derivative AGU661 exhibits strong potency as a mPGES-1 inhibitor in a cell-free assay of pr…
View article: Amino acid-equipped poly(ester amide) nanoparticles for improved encapsulation efficiency of lipophilic anti-inflammatory 6BIGOE based on molecular dynamic simulations
Amino acid-equipped poly(ester amide) nanoparticles for improved encapsulation efficiency of lipophilic anti-inflammatory 6BIGOE based on molecular dynamic simulations Open
The efficient delivery of lipophilic drugs still remains a major challenge in pharmaceutical nanotechnology, particularly due to limitations in drug loading, drug stability, and the biocompatibility of polymeric nanocarriers. Poly(ester am…
View article: PRIAMOS: A technique for mixing embedding media for freely adjusting pH value and refractive index (RI) for optical clearing (OC) of whole tissue samples
PRIAMOS: A technique for mixing embedding media for freely adjusting pH value and refractive index (RI) for optical clearing (OC) of whole tissue samples Open
Investigations of biological samples often require sample transparency, which is achieved by embedding the sample in a high‐refractive index (RI) medium to obtain a homogenous RI distribution in the sample, referred to as optical clearing …
View article: Unraveling the Hierarchical Self‐Assembly of Amphiphilic Block Copolymer‐Peptide Conjugates by Tip‐Enhanced Raman Spectroscopy
Unraveling the Hierarchical Self‐Assembly of Amphiphilic Block Copolymer‐Peptide Conjugates by Tip‐Enhanced Raman Spectroscopy Open
Self‐assembly of block copolymers in solution provides access to different nanostructures depending on block composition and processing conditions. However, more complex hierarchical nanostructures as found in nature remain challenging to …
View article: Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in PLGA Nanoparticles
Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in PLGA Nanoparticles Open
Influenza A virus (IAV) infections continue to threaten public health. Current strategies, such as vaccines and antiviral drugs, are limited due to their time-consuming development and drug-resistant strains. Therefore, new effective treat…
View article: Smart sensor particles for intracellular tracing of reactive oxygen species by transmission electron microscopy
Smart sensor particles for intracellular tracing of reactive oxygen species by transmission electron microscopy Open
Reactive oxygen species (ROS) are important markers for understanding the cellular condition in the context of diseases and inflammatory reactions to nanoparticle uptake. Their precise localization in the cellular context by high resolutio…
View article: Mild Oxidation of Plant Polyphenols Yields Modular Nanoparticle‐Forming Materials with Drug Loading Capabilities
Mild Oxidation of Plant Polyphenols Yields Modular Nanoparticle‐Forming Materials with Drug Loading Capabilities Open
Plant polyphenols have attracted interest as green precursors for functional materials due to their unique chemical features. Here, an approach to formulate nanoparticles (NPs) from a hydrophobic (quercetin; QCT) and a hydrophilic (tannic …
View article: Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in Plga Nanoparticles
Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in Plga Nanoparticles Open
Influenza A virus (IAV) infections continue to threaten public health. Current strategies, such as vaccines and antiviral drugs, are limited due to time-consuming development and drug-resistant strains. Therefore, new effective treatments …
View article: Poly(2‐ethyl‐2‐oxazoline) (POx) as Poly(ethylene glycol) (PEG)‐Lipid Substitute for Lipid Nanoparticle Formulations
Poly(2‐ethyl‐2‐oxazoline) (POx) as Poly(ethylene glycol) (PEG)‐Lipid Substitute for Lipid Nanoparticle Formulations Open
Polyoxazolines have long been considered as promising alternatives to poly(ethylene glycol) (PEG) due to their comparable properties, in particular regarding their stealth effect toward the immune system. Lipid nanoparticles (LNPs), as uti…
View article: Supramolecular Polymer Bottlebrushes: In Situ Assessment of Noncovalent Assemblies in Human Serum by Analytical Ultracentrifugation
Supramolecular Polymer Bottlebrushes: In Situ Assessment of Noncovalent Assemblies in Human Serum by Analytical Ultracentrifugation Open
For nanomedical targeting and drug delivery purposes, the noncovalent assembly of polymer building blocks into defined nanostructures is an intense area of research. One of the key assets desirable to know for the potential nanocarrier is …
View article: Matching drug and polymer for efficient delivery of anti-inflammatory drugs: PLGA, polyesteramides, and acetalated dextran
Matching drug and polymer for efficient delivery of anti-inflammatory drugs: PLGA, polyesteramides, and acetalated dextran Open
Polymeric nanoparticles from PLGA, polyesteramides, and acetalated dextran enabled efficient delivery of anti-inflammatory drugs, highlighting the importance of polymer–drug matching for optimal formulation performance.
View article: Polyoxazolines with Cholesterol Lipid Anchor for Fast Intracellular Delivery
Polyoxazolines with Cholesterol Lipid Anchor for Fast Intracellular Delivery Open
Due to the increasing challenges posed by the growing immunity to poly(ethylene glycol) (PEG), there is growing interest in innovative polymer‐based materials as viable alternatives. In this study, the advantages of lipids and polymers are…
View article: Optimizing Biocompatibility and Gene Delivery with DMAEA and DMAEAm: A Niacin-Derived Copolymer Approach
Optimizing Biocompatibility and Gene Delivery with DMAEA and DMAEAm: A Niacin-Derived Copolymer Approach Open
Gene therapy is pivotal in nanomedicine, offering a versatile approach to disease treatment. This study aims to achieve an optimal balance between biocompatibility and efficacy, which is a common challenge in the field. A copolymer library…
View article: Anti‐Inflammatory Potential of Beclometasone‐Loaded Filomicelles on Activated Human Monocytes
Anti‐Inflammatory Potential of Beclometasone‐Loaded Filomicelles on Activated Human Monocytes Open
Polymeric micelles with a hydrophobic core represent versatile nanostructures for encapsulation and delivery of water‐insoluble drugs. Here, water‐insoluble beclometasone dipropionate (BDP) which is a potent anti‐inflammatory therapeutic a…
View article: Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles (Small 21/2024)
Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles (Small 21/2024) Open
Wormlike Polymer Micelles In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co-workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa wi…
View article: Influence of Polymer Side Chain Size and Backbone Length on the Self‐Assembly of Supramolecular Polymer Bottlebrushes
Influence of Polymer Side Chain Size and Backbone Length on the Self‐Assembly of Supramolecular Polymer Bottlebrushes Open
Hydrogen bonds are a versatile tool for creating fibrous, bottlebrush‐like assemblies of polymeric building blocks. However, a delicate balance of forces exists between the steric repulsion of the polymer chains and these directed supramol…
View article: PEG–Lipid–PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs
PEG–Lipid–PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs Open
Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG–Lipid conjugates with various functionalities (-RGD, -cRGD, -NH2, and -COOH) to create targeted drug delivery systems. Loaded with …
View article: Improving Gene Delivery: Synergy between Alkyl Chain Length and Lipoic Acid for PDMAEMA Hydrophobic Copolymers
Improving Gene Delivery: Synergy between Alkyl Chain Length and Lipoic Acid for PDMAEMA Hydrophobic Copolymers Open
In the field of gene delivery, hydrophobic cationic copolymers hold great promise. They exhibit improved performance by effectively protecting genetic material from serum interactions while facilitating interactions with cellular membranes…
View article: Evaluation of <i>in situ</i> thermal stability assessment for flow batteries and deeper investigation of the ferrocene co-polymer
Evaluation of <i>in situ</i> thermal stability assessment for flow batteries and deeper investigation of the ferrocene co-polymer Open
Reliability of common heating setups for RFBs was evaluated. The ferrocene polymer exhibited highest thermal stability among all currently studied organic materials; still, further improvements are needed to approach practical applications.
View article: PEtOxylated polyesteramide nanoparticles for the delivery of anti-inflammatory drugs
PEtOxylated polyesteramide nanoparticles for the delivery of anti-inflammatory drugs Open
Poly(ester amide)s (PEAs) consisting of l-valine (Val), glycolic acid (G), and l-isoleucine (Ile), i.e., PValG and PIleG, and various poly(2-ethyl-2-oxazoline)-block-poly(ester amide) copolymers (PEtOx-b-PEA) were investigated for their su…
View article: Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles
Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles Open
Inflammatory bowel disease (IBD) has become a globally prevalent chronic disease with no causal therapeutic options. Targeted drug delivery systems with selectivity for inflamed areas in the gastrointestinal tract promise to reduce severe …
View article: Optimization of Mixed Micelles Based on Oppositely Charged Block Copolymers by Machine Learning for Application in Gene Delivery
Optimization of Mixed Micelles Based on Oppositely Charged Block Copolymers by Machine Learning for Application in Gene Delivery Open
The COVID‐19 mRNA vaccines represent a milestone in developing non‐viral gene carriers, and their success highlights the crucial need for continued research in this field to address further challenges. Polymer‐based delivery systems are pa…
View article: How introduction of hydrolyzable moieties in POx influences particle formation – a library approach based on block copolymers comprising polyesters
How introduction of hydrolyzable moieties in POx influences particle formation – a library approach based on block copolymers comprising polyesters Open
A library of fully degradable amphiphilic block copolymers based on degradable polyoxazoline analogues and polyesters synthesized via strain-promoted azide–alkyne cycloaddition was used to obtain particle formulations in a high-throughput …
View article: PEG-Lipids: Quantitative Study of Unimers and Aggregates Thereof by the Methods of Molecular Hydrodynamics
PEG-Lipids: Quantitative Study of Unimers and Aggregates Thereof by the Methods of Molecular Hydrodynamics Open
Understanding the polymorphism of lipids in solution is the key to the development of intracellular delivery systems. Here, we study the dynamics of poly(ethylene glycol)-lipid (PEG-Lipid) conjugates aiming at a better understanding of the…
View article: Guided-deconvolution for correlative light and electron microscopy
Guided-deconvolution for correlative light and electron microscopy Open
Correlative light and electron microscopy is a powerful tool to study the internal structure of cells. It combines the mutual benefit of correlating light (LM) and electron (EM) microscopy information. The EM images only contain contrast i…