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A Bilayer Cathode Design Procedure for Li ion Batteries Using the Multilayer Doyle-Fuller-Newman Model (M-DFN) Open

Adam M. Boyce, Stephen A. Duncan · 2025

Heterogeneities in lithium ion batteries can be significant factors in electrode under utilisation and degradation while charging. Bilayer electrodes have been proposed as a convenient and scalable way to homogenise the electrode response.…

Mechanisms of Differential Signal Transduction by IFNLR1 Variants Open

Laura A. Novotny, Carla Martinez-Morant, Stephen A. Duncan, Paula Traktman, Mónika Göőz , et al. · 2025

Background Lambda interferons bind the interferon lambda receptor-1 (IFNLR1) and IL10RB heterodimer to induce interferon stimulated genes (ISGs) and impart antiviral immunity. We previously showed that protein variants derived from distinc…

TBX3 advances the developmental chromatin landscape toward the hepatic fate Open

Tabea L. Stephan, Rebecca Cullum, Sibyl Drissler, Ashleigh Thomas, Bettina M. Fuglerud , et al. · 2025

By mapping histone modifications in a human stem cell model of hepatic differentiation, we identified an enhancer landscape that is dynamic and stage specific, with many primed at the definitive endoderm stage. While hepatic enhancers gain…

A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease Open

Caren Doueiry, Christiana S. Kappler, Carla Martinez-Morant, Stephen A. Duncan · 2024

The incidence of nonalcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated fatty liver disease (MAFLD), is increasing in adults and children. Unfortunately, effective pharmacological treatments remain unavailable. Singl…

A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries Open

E. C. Tredenick, Scot Wheeler, Ross Drummond, Yang‐Kook Sun, Stephen A. Duncan , et al. · 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni _…

A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries Open

E. C. Tredenick, Scot Wheeler, Ross Drummond, Yang‐Kook Sun, Stephen A. Duncan , et al. · 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni _…

A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries Open

E. C. Tredenick, Scot Wheeler, Ross Drummond, Yang‐Kook Sun, Stephen A. Duncan , et al. · 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni _…

A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries Open

E. C. Tredenick, Scot Wheeler, Ross Drummond, Yang‐Kook Sun, Stephen A. Duncan , et al. · 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni _…

A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries Open

E. C. Tredenick, Scot Wheeler, Ross Drummond, Yang‐Kook Sun, Stephen A. Duncan , et al. · 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni _…

A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B Open

Jui-Tung Liu, Caren Doueiry, Yulin Jiang, Josef Blaszkiewicz, Mary Paige Lamprecht , et al. · 2023

Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which can cause severe cardiovascular disease. Statins, bile acid sequestrants, PCSK9 inhibitors, and cholester…

CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth Open

Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford , et al. · 2023

The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of metabolism and cell growth by sensing diverse environmental signals, including amino acids. The GATOR2 complex is a key component linking amino acid signals to m…

GATA6 is a crucial factor for <i>Myocd</i> expression in the visceral smooth muscle cell differentiation program of the murine ureter Open

Jennifer Kurz, Anna‐Carina Weiss, Timo H. Lüdtke, Lena Deuper, Mark‐Oliver Trowe , et al. · 2022

Smooth muscle cells (SMCs) are a crucial component of the mesenchymal wall of the ureter, as they account for the efficient removal of the urine from the renal pelvis to the bladder by means of their contractile activity. Here, we show tha…

Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm Open

James A. Heslop, Behshad Pournasr, Stephen A. Duncan · 2022

In addition to cooperatively driving transcriptional programs, emerging evidence supports transcription factors interacting with one another to modulate the outcome of binding events. As such, transcription factor interactions fine-tune th…

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells Open

Kareem A. Heslop, Pieter B. Burger, Christiana S. Kappler, Ashish K. Solanki, Mónika Göőz , et al. · 2022

Advancements in Disease Modeling and Drug Discovery Using iPSC-Derived Hepatocyte-like Cells Open

Josef Blaszkiewicz, Stephen A. Duncan · 2022

Serving as the metabolic hub of the human body, the liver is a vital organ that performs a variety of important physiological functions. Although known for its regenerative potential, it remains vulnerable to a variety of diseases. Despite…

Modelling the Impedance Response of Graded LiFePO<sub>4</sub> Cathodes for Li-Ion Batteries Open

Ross Drummond, Chuan Cheng, Patrick S. Grant, Stephen A. Duncan · 2022

Graded electrodes for Li-ion batteries aim to exploit controlled variations in local electrode microstructure to improve overall battery performance, including reduced degradation rates and increased capacity at high discharge rates. Howev…

Author Correction: Adipose expression of CREB3L3 modulates body weight during obesity Open

Maximilian McCann, Yanliang Li, Marcos D Muñoz, Victoria Gil, Guifen Qiang , et al. · 2021

Adipose expression of CREB3L3 modulates body weight during obesity Open

Maximilian McCann, Yanliang Li, Marcos D Muñoz, Victoria Gil, Guifen Qiang , et al. · 2021

GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells Open

James A. Heslop, Behshad Pournasr, Jui-Tung Liu, Stephen A. Duncan · 2021

49483 Evaluating the Role of IFNLR1 Receptor Dynamics and Plasticity in Regulating Cellular Response to Interferons Open

Gray Evans, Christiana S. Kappler, Ray Liu, Juliana Debrito Carten, Cody M. Orr , et al. · 2021

IMPACT: We hope to provide a more nuanced understanding of the type-III IFN system, thereby exploring its therapeutic potential in the realm of infectious diseases. OBJECTIVES/GOALS: The role of IFNLR1 receptor dynamics and plasticity in r…

Generation of isogenic Propionyl-CoA carboxylase beta subunit (PCCB) deficient induced pluripotent stem cell lines Open

Behshad Pournasr, Stephen A. Duncan · 2020

FoxA factors: the chromatin key and doorstop essential for liver development and function Open

James A. Heslop, Stephen A. Duncan · 2020

Pioneer factors are transcriptional regulators with the capacity to bind inactive regions of chromatin and induce changes in accessibility that underpin cell fate decisions. The FOXA family of transcription factors is well understood to ha…

Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting <i>ATP1a1</i> Open

Jui-Tung Liu, James Corbett, James A. Heslop, Stephen A. Duncan · 2020

Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of …

Peer Review #1 of "Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 (v0.1)" Open

Jui-Tung Liu, James Corbett, James A. Heslop, Stephen A. Duncan · 2020

Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy.By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of i…

Modeling hepatitis C virus infection using human induced pluripotent stem cells Open

Robert E. Schwartz, Kartik Trehan, Linda Andrus, Timothy P. Sheahan, Alexander Ploß , et al. · 2020

Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-spec…

Decision letter: GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm Open

Stephen A. Duncan · 2019

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Damaging GATA6 variants cause cardiac outf…

iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery Open

James Corbett, Stephen A. Duncan · 2019

The liver is one of the largest organs in the body and is responsible for a diverse repertoire of metabolic processes. Such processes include the secretion of serum proteins, carbohydrate and lipid metabolism, bile acid and urea synthesis,…

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II Open

Ann DeLaForest, Francesca Di Furio, Ran Jing, Amy Ludwig-Kubinski, Kirk Twaroski , et al. · 2018

Elucidating the molecular basis of cell differentiation will advance our understanding of organ development and disease. We have previously established a protocol that efficiently produces cells with hepatocyte characteristics from human i…

A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome Open

Ran Jing, James Corbett, Jun Cai, Gyda Beeson, Craig C. Beeson , et al. · 2018

Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of treatments has been impeded by an inability to culture and manipulate MTDPS3 prim…

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery Open

Jui-Tung Liu, Mary Paige Lamprecht, Stephen A. Duncan · 2018

The ability to differentiate human induced pluripotent stem cells (iPSCs) into hepatocyte-like cells (HLCs) provides new opportunities to study inborn errors in hepatic metabolism. However, to provide a platform that supports the identific…

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