Stephen Adelstein
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View article: A semi‐automated <scp>ASC</scp> speck assay to evaluate pyrin inflammasome activation
A semi‐automated <span>ASC</span> speck assay to evaluate pyrin inflammasome activation Open
Objective To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods Overactivity of the pyrin inflammasome pathway and ASC speck oligomerisation in response to stimulation with low c…
View article: High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma
High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma Open
Aims Mesothelin (MSLN) is a cancer‐associated antigen that is overexpressed in malignancies such as mesothelioma, pancreatic and ovarian cancer. It is also a target for novel personalised therapies, including antibodies, antibody–drug conj…
View article: A Composite Serum Biomarker Index for the Diagnosis of Systemic Sclerosis–Associated Interstitial Lung Disease: A Multicenter, Observational Cohort Study
A Composite Serum Biomarker Index for the Diagnosis of Systemic Sclerosis–Associated Interstitial Lung Disease: A Multicenter, Observational Cohort Study Open
Objective In patients with systemic sclerosis (SSc), we investigated composite serum biomarker panels for the diagnosis and risk stratification of SSc–associated interstitial lung disease (SSc‐ILD). Methods We analyzed 28 biomarkers in 640…
View article: A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy
A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy Open
Autoimmune Autonomic Ganglionopathy (AAG) is an uncommon immune-mediated neurological disease that results in failure of autonomic function and is associated with autoantibodies directed against the ganglionic acetylcholine receptor (gnACH…
View article: Supplementary Material for: Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort
Supplementary Material for: Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort Open
Background and objective: The research term “interstitial pneumonia with autoimmune features” (IPAF) encompasses interstitial lung disease (ILD) patients with autoimmune features not meeting diagnostic criteria for a defined connective tis…
View article: Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease
Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease Open
Objective To investigate the associations of Graves' disease (GD) severity, autoimmunity and longitudinal liver enzyme changes with time in a cohort with well‐characterized GD. Design Retrospective cohort study. Patients Patients diagnosed…
View article: Role of Autoantibodies in the Diagnosis of Connective-Tissue Disease ILD (CTD-ILD) and Interstitial Pneumonia with Autoimmune Features (IPAF)
Role of Autoantibodies in the Diagnosis of Connective-Tissue Disease ILD (CTD-ILD) and Interstitial Pneumonia with Autoimmune Features (IPAF) Open
The diagnosis of interstitial lung disease (ILD) requires meticulous evaluation for an underlying connective tissue disease (CTD), with major implications for prognosis and management. CTD associated ILD (CTD-ILD) occurs most commonly in t…
View article: A call for uniformity in implementing the IPAF (interstitial pneumonia with autoimmune features) criteria
A call for uniformity in implementing the IPAF (interstitial pneumonia with autoimmune features) criteria Open
We commend Oldham et al . [1] for their recent article using the new European Respiratory Society/American Thoracic Society criteria for interstitial pneumonia with autoimmune features (IPAF) to re-characterise a cohort of interstitial lun…
View article: Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets Open
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partiall…
View article: STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function Open
Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their dev…